Ranzol-XR (500mg) 14 Tablets

Ranolazine's primary mechanism of action is its ability to selectively inhibit late sodium (Na+) currents in the heart. This inhibition reduces the inward movement of sodium ions during the late phase of the cardiac action potential, which helps to decrease the intracellular sodium concentration. As a result, the activity of the sodium-calcium exchanger is reduced, leading to less calcium influx. This modulation of calcium dynamics has several effects. Firstly, it decreases the electrical activity of the heart, leading to a reduction in myocardial oxygen demand. Secondly, it improves diastolic function by enhancing calcium handling within the cardiac cells, allowing for better relaxation of the myocardium. These actions contribute to Ranolazine's therapeutic benefits in managing angina and certain types of arrhythmias.

Antianginal agent

Tablet

The following are the uses of Ranolazine 500mg Tablet:

• Used for treating chronic angina in patients who have not responded adequately to other anti-anginal medications.
• Used to reduce the frequency of angina attacks and improve exercise tolerance.
• Used to manage symptoms of chest pain and discomfort associated with coronary artery disease.
• Used to enhance blood flow to the heart by affecting specific ion channels in heart muscles.
• Used for long-term treatment to improve heart function and reduce the workload on the heart.
• Used to control symptoms and improve the overall quality of life for patients with stable angina.
• Used as an adjunct therapy alongside other medications to provide better angina relief.

In the case of an overdose of Ranolazine 500mg Tablets, several symptoms may occur, including severe dizziness, fainting, slow heartbeat, and difficulty in breathing. If an overdose is suspected, immediate medical attention is required. It is important to seek help from a healthcare professional or a poison control center, who can provide guidance on the necessary steps to take. Prompt action can help manage the effects of an overdose and ensure appropriate treatment.

In the case of a missed dose of Ranolazine 500mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule. It is recommended to set a reminder or use a pill organizer to help you remember to take your medication as prescribed.

To take Ranolazine 500mg Tablet, swallow the tablet whole with a full glass of water, usually twice a day, or as directed by your healthcare professional, and it can be taken with or without food.

Following are the conditions/situations when Ranolazine 500mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Ranolazine or other similar medications.
• Not recommended for patients with a severe liver impairment or severe kidney disease.
• Contraindicated in patients with a history of long QT syndrome or other heart rhythm disorders.
• Should not be used if the patient is currently taking certain other medications such as rifampin, phenytoin, or carbamazepine, as these can affect the metabolism of Ranolazine.
• Not suitable for individuals with low blood pressure (hypotension) or slow heart rate (bradycardia).
• Should be avoided during breastfeeding as it may pass into breast milk and harm a nursing infant.
• Not recommended for children below 18 years of age, as the safety and efficacy have not been established in this age group.
• Contraindicated in patients with a history of heart failure, as it may worsen the condition.
• Should not be used if the patient has a history of liver or kidney transplant.

The side effects of Ranolazine 500mg Tablet may include:

• Dizziness
• Headache
• Nausea and vomiting
• Diarrhea
• Constipation
• Fatigue or weakness
• Drowsiness
• Skin rashes or itching

Following are the precautions and warnings for Ranolazine 500mg Tablet:

• This medication is not recommended for individuals with a known allergy to Ranolazine or any of its excipients.
• Ranolazine can cause a rare but serious condition called QT prolongation, which can lead to an irregular heartbeat. It should be used with caution in patients with a history of heart disease, liver problems, or those taking other medications that may affect heart rhythm.
• Patients with severe kidney disease should not take Ranolazine as it can lead to increased drug levels in the body. Dosage adjustments are necessary for patients with mild to moderate kidney issues.
• Elderly patients may be more sensitive to the effects of this medication, particularly the risk of QT prolongation.
• Ranolazine can cause dizziness and blurred vision. Patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• It may cause a condition called rhabdomyolysis, which can lead to severe muscle breakdown and kidney damage. Seek medical attention if you experience muscle pain, weakness, or dark-colored urine.
• This medication should be used with caution in patients with a history of liver disease, as it is metabolized by the liver. Regular monitoring of liver function may be required.
• Ranolazine may interact with other medications, including CYP3A4 inhibitors and inducers, affecting its effectiveness. Inform your doctor about all medications you are taking.

Following are the drug interactions for Ranolazine 500mg Tablet:

• Ranolazine can prolong the QT interval, and its use with other QT-prolonging medications like cisapride, pimozide, or certain antiarrhythmic drugs should be avoided due to the increased risk of serious arrhythmias.
• The effect of Ranolazine may be reduced by strong CYP3A inducers such as rifampin, potentially requiring dosage adjustments.
• Concomitant use with strong CYP3A inhibitors like ketoconazole or clarithromycin can increase Ranolazine levels, necessitating close monitoring and possible dose reduction.
• Grapefruit juice is a CYP3A4 inhibitor and should be avoided as it can increase Ranolazine plasma concentrations.
• Ranolazine may affect the metabolism of statins (e.g., simvastatin, atorvastatin), potentially increasing the risk of muscle-related side effects, and dosage adjustments may be needed.
• The combination with digoxin can increase digoxin levels, requiring close monitoring of digoxin concentrations.
• Caution is advised when using Ranolazine with other medications that lower blood pressure, as it may lead to additive hypotensive effects.

Following are the food interactions for Ranolazine 500mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can increase the concentration of Ranolazine in the blood, potentially leading to an increased risk of side effects.
• Alcohol consumption should be limited as it may exaggerate the dizziness and drowsiness associated with Ranolazine.
• Avoid high-fat meals as they can decrease the absorption of Ranolazine, potentially reducing its effectiveness.
• Avoid consuming Seville oranges (often used in marmalades) as they can also increase the levels of Ranolazine in the blood.
• Be cautious with caffeine intake as Ranolazine may increase its effects, leading to excessive nervousness and irritability.
• Avoid consuming large amounts of pomegranate juice as it may interact with Ranolazine, affecting its metabolism.
• Always follow the dosage instructions provided by your healthcare professional, especially regarding the timing of the medication in relation to meals.
• Inform your doctor about your dietary habits to ensure safe and effective use of Ranolazine.

Ranolazine 500mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (68°F to 77°F). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It is crucial to store medications away from children and pets to prevent accidental ingestion. Do not transfer the tablets to a different container as it may lead to medication mix-ups. Always check the expiration date, and do not use the medication if it is expired. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult a pharmacist for safe disposal options. Proper disposal ensures the protection of both individuals and the environment.

Following are the quick tips for Ranolazine 500mg Tablet:

• Take the tablet as directed by your doctor; do not change the dosage without medical advice.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• You can take it with or without food, but be consistent with your choice.
• Maintain a consistent schedule; if you take it with food, do so at the same time each day.
• Do not miss doses; take it regularly for the full benefit.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Store at room temperature, away from moisture and heat.