Raxil CR (25mg) 30 Tablets

Paroxetine 25mg tablets primarily exert their therapeutic effects through selective serotonin reuptake inhibition (SSRI). By selectively binding to the presynaptic serotonin transporter, paroxetine inhibits the reabsorption of serotonin (5-hydroxytryptamine, 5-HT) into the presynaptic neuron, resulting in increased levels of serotonin in the synaptic cleft. This augmentation of serotonin concentration facilitates enhanced serotonergic neurotransmission, which is believed to play a crucial role in alleviating depressive symptoms. Paroxetine's mechanism of action is focused on modulating serotonin levels, which is thought to contribute to its efficacy in treating various psychiatric disorders, particularly depression and anxiety-related conditions.

Selective Serotonin Reuptake Inhibitor (SSRI).

Tablet

The following are the uses of Paroxetine 25mg Tablet:

• Used for managing depression and improving mood by balancing neurotransmitters in the brain.
• Used for treating severe anxiety disorders, helping to reduce excessive worry and fear.
• Used for Obsessive-Compulsive Disorder (OCD) to lessen intrusive thoughts and compulsive behaviors.
• Used for Post-Traumatic Stress Disorder (PTSD) to alleviate symptoms like flashbacks and nightmares.
• Used for managing panic disorders, reducing the frequency and intensity of panic attacks.
• Used for certain eating disorders, such as bulimia nervosa, to help regulate eating patterns.
• Used for premenstrual dysphoric disorder (PMDD) to relieve emotional and physical symptoms.
• Used for managing hot flashes associated with menopause, providing relief from discomfort.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Paroxetine is a drug commonly used to treat major depressive disorder (MDD).
• The average dose of Paroxetine for MDD is 20mg daily but this dose may be adjusted upwards or downwards depending on the patient's response
• For panic attacks, the average dose of Paroxetine is between 5mg and 10mg taken either once or twice per day. The dose may be increased in increments of 5mg at weekly intervals if well tolerated
• For obsessive-compulsive disorder (OCD), the recommended dose of Paroxetine is between 20mg and 50mg per day.
• For post-traumatic stress disorder (PTSD), it is recommended to initiate Paroxetine treatment at 20mg per day. Dose adjustments should be done at intervals of 3 to 4 days, with a maximum recommended dose of 50mg per day.

In the case of an overdose of Paroxetine 25mg Tablets, it is important to act swiftly. Initial symptoms may include nausea, vomiting, dizziness, and restlessness. In more severe cases, individuals might experience rapid heart rate, seizures, and even loss of consciousness. Immediate medical intervention is necessary, and healthcare professionals should be contacted without delay to provide appropriate treatment and ensure the patient's safety.

In the case of a missed dose of Paroxetine 25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid doubling the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication routine. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To take Paroxetine 25mg Tablets, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, without crushing or chewing it.

Here are the conditions and situations when Paroxetine 25mg Tablet should not be taken:

• Avoid using Paroxetine if you are allergic to any of its ingredients, especially Paroxetine or similar antidepressant medications.
• Do not take this medication if you are currently using MAO inhibitors or have used them within the last 14 days.
• Contraindicated in individuals with narrow-angle glaucoma.
• Not suitable for patients with a history of liver problems or impaired liver function.
• Should not be used in patients with kidney disease or those undergoing kidney dialysis.
• Avoid Paroxetine if you have a bleeding disorder or are taking blood thinners.
• Do not use this medication if you have recently had a heart attack or have heart disease.
• Contraindicated in individuals with a history of seizures or epilepsy.
• Not recommended for patients with diabetes as it may affect blood sugar levels.
• Should not be used in individuals with severe hypertension (high blood pressure).
• Avoid if you have or have had low sodium levels in your blood.
• Do not take Paroxetine if you are pregnant or breastfeeding, as it may harm the baby.
• Not suitable for children and adolescents under 18 years of age.

The side effects of Paroxetine 25mg Tablet may include:

• Nausea and vomiting
• Dry mouth
• Diarrhea or constipation
• Dizziness or lightheadedness
• Insomnia or drowsiness
• Increased sweating
• Sexual dysfunction, including decreased libido and delayed orgasm
• Weight changes (gain or loss)

Following are the precautions and warnings for Paroxetine 25mg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Paroxetine or similar antidepressants.
• May cause an increase in suicidal thoughts or behavior, especially in children, adolescents, and young adults; close monitoring is essential.
• Patients with a history of seizures or epilepsy should exercise caution as Paroxetine may lower the seizure threshold.
• Elderly patients may be more sensitive to the side effects; dosage adjustments might be necessary.
• This medication can cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how it affects them.
• Paroxetine may lead to weight gain, so regular monitoring of weight is advised.
• Discontinuation of the medication should be gradual to minimize withdrawal symptoms.

Following are the drug interactions for Paroxetine 25mg Tablet:

• Paroxetine may increase serotonin levels when combined with other serotonergic drugs like SSRIs, SNRIs, triptans, or certain opioids, leading to serotonin syndrome.
• It should not be taken with monoamine oxidase inhibitors (MAOIs), as this combination can result in serious reactions including serotonin syndrome.
• Anticoagulants such as warfarin may have their effects enhanced by Paroxetine, requiring close monitoring for bleeding.
• Central nervous system depressants (e.g., benzodiazepines, alcohol) can have their effects potentiated, leading to increased sedation and impaired judgment.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase bleeding risk when used concurrently.
• Paroxetine can elevate blood levels of some medications metabolized by the liver, including anticonvulsants and antipsychotics, potentially enhancing side effects.
• Drugs that affect liver enzymes may alter the metabolism of Paroxetine, requiring dosage adjustments.

Following are the food interactions for Paroxetine 25mg Tablet:

• Avoid consuming alcohol while taking this medication as it can increase the risk of side effects and may lead to excessive drowsiness and sedation.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the blood levels of Paroxetine, potentially causing an increase in side effects.
• High-fat meals can affect the absorption of Paroxetine; it is recommended to maintain a consistent diet to ensure stable blood levels of the medication.
• Avoid caffeine or reduce its intake as it can enhance the effects of Paroxetine on the nervous system, possibly leading to increased anxiety or nervousness.
• Avoid aged or fermented foods containing tyramine, such as aged cheeses, cured meats, and certain types of beer, as Paroxetine may interact with tyramine and cause a sudden increase in blood pressure.
• Avoid herbal supplements like St. John's Wort, as it can reduce the effectiveness of Paroxetine and potentially lead to serotonin syndrome.
• Maintain a balanced diet and stay hydrated, as Paroxetine may cause mild gastrointestinal side effects.
• Consult a healthcare professional for personalized advice on diet and medication interactions.

Paroxetine 25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, ensuring the lid is tightly sealed to maintain their integrity and prevent moisture absorption. It is crucial to maintain a consistent room temperature, avoiding exposure to direct sunlight, heat sources, or extreme temperatures, as these can degrade the medication. Always check the expiration date on the packaging and never use the tablets after the expiry date. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, consult your local pharmacy or healthcare provider for safe disposal options to protect the environment and prevent accidental ingestion by others or animals. Keep the medication out of children's reach at all times.

Following are the quick tips for Paroxetine 25mg Tablet:

• Start with a lower dose and gradually increase as directed by your doctor to minimize side effects.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Avoid alcohol consumption while taking Paroxetine, as it may intensify side effects.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Do not stop taking the medication abruptly; follow your doctor's instructions for tapering off.
• Store the tablets at room temperature, away from moisture and light.

Paroxetine is a prescription medication that treats depression, anxiety, and other mental health issues. While it is essential to monitor your overall health when taking Paroxetine, it is even more important to adjust the dosage as needed. Your doctor may recommend specific lab tests to monitor vital functions and health, including blood count, electrolytes and creatinine, liver function tests, kidney function tests, blood sugar and lipids profile, and electrocardiogram. Blood count tests examine the types and amounts of blood cells in the body, which helps to identify signs of anemia or infections. Tests that measure electrolytes such as sodium, potassium, chloride, and bicarbonate are vital to assess potential nerve and muscle function issues. Creatinine indicators of kidney function assist in diagnosing kidney problems. Liver function tests measure enzymes and proteins in the blood to assess liver function and identify liver damage or other abnormalities. Aside from electrolytes and creatinine, a more comprehensive kidney function panel may be necessary to monitor any potential Paroxetine effects on kidneys. Diabetic or pre-diabetic patients must get their blood sugar levels monitored, especially if they are taking Paroxetine. It is also crucial to monitor cholesterol and triglyceride levels through a lipid profile since depression and antidepressants can affect these lipids. Electrocardiogram (ECG) tests record the heart's electrical activity, helping to identify heart abnormalities or signs of drug-induced long-QT syndrome, which causes irregular heartbeats. Your doctor will determine the necessary frequency and additional tests based on your individual needs and potential risks. It is essential to speak with your doctor or pharmacist to ensure Paroxetine's safe and effective use.