Recormon (5000IU/0.3ml) 6 Pre-Filled Syringes

The mechanism of action of methoxy polyethylene glycol-epoetin beta is primarily through its ability to stimulate erythropoiesis, or red blood cell production. It is a modified form of erythropoietin, a hormone naturally produced by the kidneys. By binding to erythropoietin receptors on progenitor cells in the bone marrow, it promotes the survival, proliferation, and differentiation of red blood cell precursors, leading to an increase in hemoglobin levels and red blood cell production. This synthetic erythropoiesis-stimulating agent mimics the biological activity of endogenous erythropoietin, thereby improving oxygen delivery to tissues and alleviating anemia.

Stimulating erythropoiesis agent.

Injection

The following are the uses of methoxy polyethylene glycol-epoetin beta Syringe:

• Used for treating anemia in patients with chronic kidney disease, both on dialysis and not on dialysis.
• Used to stimulate red blood cell production and manage anemia-related symptoms.
• Used to improve oxygen delivery to tissues by increasing hemoglobin levels.
• Used as an alternative for patients who have not responded adequately to other erythropoiesis-stimulating agents.
• Used to reduce the need for blood transfusions in certain patient populations.
• Used to enhance quality of life and overall well-being in patients with anemia.
• Used to manage anemia in patients with cancer undergoing chemotherapy.
• Used to stabilize hemoglobin levels and prevent anemia-related complications.

In the case of an overdose of methoxy polyethylene glycol-epoetin beta Syringe, the primary concern is the potential for severe side effects. Overdosing may lead to increased blood pressure, headache, and seizures. Prompt medical attention is necessary to manage these symptoms effectively. Healthcare professionals should closely monitor vital signs and provide appropriate supportive care to mitigate the risks associated with excessive doses of this medication.

In the case of a missed dose of methoxy polyethylene glycol-epoetin beta Syringe, it is important to follow the specific instructions provided by your healthcare professional. If you realize you've missed a dose, administer it as soon as possible, but if it's close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer methoxy polyethylene glycol-epoetin beta Syringe, gently swirl the syringe to ensure the solution is uniformly mixed, draw the prescribed dose into the syringe, and inject it subcutaneously at the injection site as directed by your healthcare professional.

Following are the conditions when methoxy polyethylene glycol-epoetin beta Syringe should not be used:

• Should not be administered to individuals with a known hypersensitivity or allergy to methoxy polyethylene glycol-epoetin beta or any of its excipients.
• Contraindicated in patients with uncontrolled hypertension (high blood pressure).
• Not suitable for individuals with certain types of anemia, such as hemolytic anemia or unexplained anemia.
• Should not be used in patients with a history of epilepsy or seizures.
• Contraindicated in individuals with thrombocytopenia (low platelet count) or a history of blood clotting disorders.
• Not recommended for patients with certain types of cancer, especially those with rapid cell growth or those undergoing chemotherapy.
• Should not be administered to individuals with severe renal impairment or end-stage renal disease.
• Contraindicated during pregnancy or breastfeeding, unless the potential benefits outweigh the risks.
• Should not be used in patients with a history of stroke or transient ischemic attack (TIA).

The side effects of methoxy polyethylene glycol-epoetin beta Syringe may include:

• Severe allergic reactions (rare)
• High blood pressure
• Pain, redness, or swelling at the injection site
• Joint pain
• Headache
• Fatigue or weakness
• Nausea and vomiting
• Skin rashes or itching

Following are the precautions and warnings for methoxy polyethylene glycol-epoetin beta Syringe:

• Not recommended for individuals with a history of allergic reactions to methoxy polyethylene glycol-epoetin beta or any of its components.
• Patients with chronic kidney disease should use this medication with caution, as it may affect kidney function.
• Regular monitoring of blood pressure is necessary as it may cause hypertension.
• Avoid if you have uncontrolled hypertension, as it can worsen blood pressure.
• Patients with a history of seizures or epilepsy should exercise caution, as it may increase the risk of seizures.
• Discontinue use and seek medical attention if you experience any signs of serious allergic reactions, such as difficulty breathing, hives, or swelling.
• Consult your doctor if you have any pre-existing medical conditions or are taking other medications to ensure safe use.

Following are the drug interactions for methoxy polyethylene glycol-epoetin beta Syringe:

• May interact with other erythropoiesis-stimulating agents, increasing the risk of adverse effects.
• Use with caution alongside antihypertensive medications, as it may cause further blood pressure reduction.
• Monitor closely when using with myelosuppressive drugs, as it can affect bone marrow response.
• Concomitant use with cytotoxic chemotherapy may require dose adjustments.
• Could potentially enhance the effects of anticoagulants, requiring close monitoring.
• May increase the risk of bleeding when combined with antiplatelet drugs.
• Interactions with other drugs metabolized by the kidneys may alter methoxy polyethylene glycol-epoetin beta's clearance.

Following are the food interactions for Methoxy polyethylene glycol-epoetin beta Syringe:

• Avoid consuming alcohol as it may interact with this medication and increase the risk of side effects related to the cardiovascular system.
• Caffeine-containing products like coffee, tea, energy drinks, and certain soft drinks should be limited as they may affect blood pressure and heart rate.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially inhibit the breakdown of the medication, leading to increased levels in the body.
• Avoid high-salt foods as this medication may increase blood pressure and sodium levels.
• Limit foods rich in vitamin K (such as spinach, kale, and broccoli) as this medication may affect blood clotting.
• Consume a balanced diet with moderate amounts of protein, as high protein intake may impact the effectiveness of the drug.
• Stay hydrated by drinking adequate water, as this medication may affect fluid balance in the body.

Methoxy polyethylene glycol-epoetin beta Syringe should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F). Protect the syringe from excessive heat, direct sunlight, and freezing conditions as these can degrade the medication. Store it in its original packaging to maintain sterility and prevent contamination. Ensure the syringe is kept out of sight and reach of children and pets to avoid accidental exposure. When disposing of used or expired syringes, follow local guidelines for medical waste disposal, or consult your healthcare provider for appropriate methods. Do not dispose of the syringe in regular household trash or recycling bins. Responsible storage and disposal practices are crucial to ensure safety and environmental protection.

Following are the quick tips for methoxy polyethylene glycol-epoetin beta Syringe:

• Consult your healthcare professional for detailed instructions on using the syringe.
• Ensure the syringe is properly labeled with your name and medication details.
• Check the expiry date before use and discard if expired.
• Store the syringe as directed on the packaging; avoid extreme temperatures.
• Wash your hands thoroughly before handling the syringe to maintain hygiene.
• Inject the medication as instructed by your healthcare provider, following the prescribed dosage.
• Do not reuse or share the syringe to prevent infection and ensure sterility.