Relispa Forte (80mg) 4ml, 10 Ampoule Injections

Drotaverine's primary mechanism of action is as a spasmolytic agent, targeting smooth muscle contractions. It acts by inhibiting phosphodiesterase (PDE) enzymes, particularly PDE4, which leads to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This rise in cAMP relaxes smooth muscle cells by reducing the influx of calcium ions, thereby preventing the activation of myosin light-chain kinase and subsequent muscle contraction. By modulating these intracellular signaling pathways, drotaverine effectively alleviates smooth muscle spasms without affecting normal intestinal motility.

Drotaverine 80mg

Antispasmodic/Spasmolytic

Injection

The following are the uses of Drotaverine 80mg injection:

• Used for relieving painful muscle spasms, especially in the gastrointestinal tract.
• Used for treating abdominal pain and discomfort in conditions like irritable bowel syndrome.
• Used for managing menstrual pain and cramps.
• Used for reducing muscle spasms during medical procedures.
• Used for providing relief in renal colic and biliary colic.
• Used for alleviating pain and spasms in urological and gynecological procedures.
• Used for improving blood flow to organs by relaxing blood vessels.

In the case of an overdose of Drotaverine 80mg injection, it is crucial to seek medical assistance promptly. Symptoms may include severe drowsiness, excessive sweating, and an irregular heartbeat. Immediate action should be taken by contacting a healthcare professional or a poison control center for guidance. They will provide specific instructions for managing the overdose, which may include supportive care and monitoring vital signs until the effects of the medication wear off. Prompt intervention is key to ensuring the best possible outcome.

In the case of a missed dose of Drotaverine 80mg injection, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is crucial to maintain a consistent dosing regimen, but if you frequently miss doses, consult your healthcare provider for advice on how to manage your medication schedule effectively.

To administer Drotaverine 80mg injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial, ensuring the correct dosage is given as prescribed by your healthcare provider.

Following are the conditions/situations when Drotaverine 80mg injection should not be administered:

• Should not be used in individuals with a known allergy or hypersensitivity to Drotaverine or any of the excipients in the injection.
• Contraindicated in patients with severe liver impairment or active liver disease.
• Not recommended for individuals with gastrointestinal obstruction or perforation.
• Should be avoided in patients with severe heart disease or uncontrolled cardiovascular conditions.
• Not suitable for women who are breastfeeding, as it may pass into breast milk.
• Should not be used in individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Contraindicated in patients with a history of acute porphyria.

The side effects of Drotaverine 80mg injection may include:

• Skin rash or itching
• Allergic reactions
• Nausea and vomiting
• Dry mouth
• Dizziness or lightheadedness
• Palpitations or increased heart rate
• Constipation or diarrhea
• Chest pain or discomfort

Following are the precautions and warnings for Drotaverine 80mg Injection:

• Not recommended for individuals with known allergies to Drotaverine or any other components of the injection.
• Must be used with caution in patients with liver or kidney dysfunction, as it may require dosage adjustments.
• Avoid in patients with gastrointestinal ulcers, bleeding disorders, or those taking anticoagulant medications.
• Elderly patients may be more susceptible to side effects and should be monitored closely.
• Should be used with caution during pregnancy and breastfeeding, only if the potential benefits outweigh the risks.
• This injection should be administered by a healthcare professional to ensure proper dosage and administration.
• If symptoms persist or worsen, seek medical advice immediately and discontinue use.

Following are the drug interactions for Drotaverine 80mg injection:

• It may interact with anticholinergic medications, reducing the effectiveness of both drugs.
• Drotaverine can decrease the absorption of tetracycline antibiotics, so they should be taken at least 2 hours apart.
• Avoid using it with other antispasmodic drugs as it may lead to excessive sedation and respiratory depression.
• The effects of muscle relaxants can be enhanced by Drotaverine, requiring close monitoring.
• It may reduce the efficacy of certain Parkinson's disease medications, necessitating dosage adjustments.
• When combined with antihypertensive medications, Drotaverine might cause a more pronounced drop in blood pressure.
• Prolonged use with opioids can lead to increased constipation and potential gastrointestinal issues.

Following are the food interactions to consider with Drotaverine 80mg injection:

• Avoid grapefruit and grapefruit juice as they can inhibit the metabolism of Drotaverine, potentially leading to increased drug levels in the body.
• Alcohol consumption should be limited as it may enhance the sedative effects of Drotaverine, causing excessive drowsiness.
• Caffeine intake should be monitored as Drotaverine may enhance its effects, potentially leading to increased heart rate and blood pressure.
• Spicy foods should be consumed with caution as Drotaverine may increase the risk of gastrointestinal irritation.
• High-fat meals might delay the absorption of Drotaverine, potentially affecting its onset of action.
• Avoid excessive salt intake as Drotaverine may reduce its excretion, leading to fluid retention.
• Consuming large amounts of dairy products may interfere with Drotaverine's absorption, affecting its effectiveness.
• Always follow the dosage instructions provided by your healthcare professional, as food interactions can vary based on individual health conditions.

Drotaverine 80mg injection should be stored in a controlled environment, preferably in a cool and dry place, ensuring it is kept away from direct sunlight, heat, and moisture. Maintain a consistent room temperature for optimal storage conditions. It is crucial to store the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Pay close attention to the expiration date, and promptly dispose of any unused or expired injections following proper pharmaceutical disposal guidelines. Avoid flushing or pouring the medication down the drain; instead, seek advice from a pharmacist or healthcare professional for appropriate disposal methods. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Drotaverine 80mg Injection:

• Administer the injection under medical supervision for optimal results.
• Ensure the injection is given at the recommended site and rate.
• Avoid rapid injection to prevent discomfort or adverse effects.
• Follow the prescribed dosage and treatment duration as advised by your doctor.
• If you experience any pain or discomfort at the injection site, inform your healthcare provider.
• Do not reuse needles or syringes; dispose of them safely.
• Store the injection as directed on the packaging, away from direct sunlight and moisture.