Reneph (50mg) 2ml, 10 Ampoule Injections

Ranitidine 50mg Injection exerts its pharmacological effect primarily by inhibiting hydrogen-potassium ATPase, an enzyme found in the stomach's parietal cells. This enzyme is crucial for the final step of gastric acid secretion. By blocking its action, ranitidine significantly reduces the production of gastric acid, leading to a decrease in the acidity of the stomach contents. This mechanism is particularly effective in treating conditions where excessive gastric acid is problematic, such as in the management of peptic ulcers and gastroesophageal reflux disease (GERD).

Histamine H2-receptor antagonist.

Injection

The following are the uses of Ranitidine 50mg Injection:

• Used for reducing stomach acid production and treating acid reflux.
• Used for managing heartburn and healing stomach ulcers.
• Used to prevent acid-related damage in the stomach and esophagus.
• Used for gastroesophageal reflux disease (GERD) relief.
• Used for treating peptic ulcer disease and its symptoms.
• Used to reduce acid levels in the stomach for overall digestive health.
• Used for rapid relief from excessive acid secretion.

In the case of an overdose of Ranitidine 50mg Injection, symptoms may include severe drowsiness, rapid or irregular heartbeat, and difficulty breathing. If a patient exhibits these signs, it is vital to seek medical assistance promptly. Treatment for overdose may involve supportive care, such as monitoring vital signs and administering intravenous fluids. In severe cases, medical professionals might employ specific medications to counteract the effects of the overdose.

In the case of a missed dose of Ranitidine 50mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is essential to maintain a consistent dosing schedule for the medication's effectiveness.

To administer Ranitidine 50mg Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the entire contents of the vial subcutaneously or intramuscularly as directed by your healthcare provider, ensuring proper needle disposal afterward.

Here are the conditions or situations when Ranitidine 50mg Injection should not be used:

• Should not be administered to patients with a known allergy or hypersensitivity to Ranitidine or other similar histamine blockers.
• Contraindicated in patients with a history of acute porphyria, a rare metabolic disorder.
• Not recommended for patients with severe kidney disease or impairment, as dosage adjustments are necessary.
• Should be avoided in patients with a history of long-term or high-dose use of proton pump inhibitors (PPIs).
• Not suitable for patients with a history of liver disease or impaired liver function.
• Should not be used in patients with a history of certain blood disorders, such as acute porphyria.
• Contraindicated during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.

The side effects of Ranitidine 50mg Injection may include:

• Headache
• Dizziness
• Diarrhea
• Constipation
• Abdominal pain
• Fatigue
• Skin rashes
• Increased liver enzymes (liver function tests may be affected)

Following are the precautions and warnings for Ranitidine 50mg Injection:

• Do not use if you are allergic to ranitidine or other similar medications.
• This medication should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Ranitidine may cause drowsiness or dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• It is important to inform your doctor about all the medications you are currently taking to avoid potential drug interactions.
• Elderly patients may be more susceptible to the side effects of ranitidine, and close monitoring is advised.
• Ranitidine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding women should exercise caution, as ranitidine is excreted in human milk and may affect nursing infants.
• Do not exceed the recommended dosage, and consult a doctor if symptoms persist or worsen.

Following are the drug interactions for Ranitidine 50mg Injection:

• Concurrent use with certain medications that require an acidic environment for absorption (e.g., atazanavir, ketoconazole) may reduce their effectiveness.
• Ranitidine can increase the plasma concentrations of triazolam and midazolam, potentially requiring dosage adjustments.
• It may decrease the clearance of procainamide and increase its blood levels, warranting close monitoring.
• The anti-malaria drug, chloroquine, may have reduced absorption when taken with Ranitidine.
• Propranolol's bioavailability may be increased by Ranitidine, necessitating careful observation.
• Theophylline's metabolism may be affected, leading to increased theophylline levels and potential toxicity.
• Ranitidine can potentially enhance the anticoagulant effect of warfarin, requiring more frequent monitoring of INR.

Following are the food interactions for Ranitidine 50mg Injection:

• Alcohol consumption should be avoided as it can increase the risk of side effects and may reduce the effectiveness of Ranitidine.
• Grapefruit and grapefruit juice are to be avoided as they can alter the metabolism of Ranitidine, potentially leading to increased plasma levels and a higher risk of adverse effects.
• High-fat meals may delay the absorption of Ranitidine, leading to a delay in the onset of action.
• Avoid caffeine-rich foods and beverages as they may increase stomach acid production and potentially reduce the medication's effectiveness.
• Spicy foods should be consumed in moderation as they can irritate the stomach and potentially worsen symptoms, especially in individuals with gastritis or peptic ulcers.
• Avoid excessive consumption of chocolate as it contains methylxanthines, which can relax the lower esophageal sphincter and potentially increase acid reflux.
• While not a food, smoking cessation is recommended as smoking can stimulate stomach acid production and impair the healing process.
• Certain foods like tomatoes, citrus fruits, and peppermint may trigger acid reflux in some individuals, and their intake should be monitored.

Ranitidine 50mg Injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with excursions permitted between 59°F and 86°F (15°C and 30°C). Protect it from light and moisture by storing it in its original packaging, ensuring the container is tightly sealed. It is crucial not to freeze the injection. Always check the expiration date, and if the solution appears discolored or contains particles, do not use it. Dispose of any unused or expired medication responsibly; do not flush or pour it into the drainage system. Consult your pharmacist or healthcare provider for appropriate disposal methods to ensure environmental safety. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Ranitidine 50mg Injection:

• Administer the injection under medical supervision for accurate dosage.
• Ensure the injection is prepared and administered by trained medical staff.
• Ranitidine can be given slowly into a vein or muscle as directed by your doctor.
• Follow the prescribed dosage and duration provided by your healthcare professional.
• Inform your doctor if you have any known allergies or are taking other medications.
• Do not drive or operate machinery until you know how this medication affects you.
• Store the injection at room temperature, away from direct sunlight and moisture.