RESCUVOLIN IMP 15MG TAB 10'S

Calcium Folinate, also known as leucovorin, is a medication primarily used as an antidote to folic acid antagonists and in combination with 5-fluorouracil chemotherapy. Its mechanism of action revolves around its role as an active form of folic acid. When administered, Calcium Folinate directly provides the body with a reduced form of folic acid, known as 5-methyltetrahydrofolate, which is essential for various biological processes. This active metabolite participates in DNA synthesis and methylation reactions, playing a crucial role in the maintenance and repair of DNA. By providing this essential metabolite, Calcium Folinate supports the normal functioning of cells and helps counteract the effects of folic acid antagonists, which interfere with folate metabolism. This mechanism is particularly important in the treatment of conditions where folate deficiency or antagonism is a concern.

CALCIUM FOLINATE

Antineoplastic.

Tablet

The following are the uses of CALCIUM FOLINATE Tablet:

• Used for treating megaloblastic and macrocytic anemias resulting from a lack of folate, especially in the elderly
• Used to prevent side effects of methotrexate in cancer treatment
• Used for reducing harmful effects on the fetus and congenital abnormalities in pregnant women with low folate levels
• Used to treat folate deficiency caused by poor diet, liver disease, or certain medications
• Used to reduce high homocysteine levels, a risk factor for heart disease
• Used for managing side effects of sulfasalazine and other medications that impact folate absorption
• Used to support healthy fetal development during pregnancy

In the case of an overdose of CALCIUM FOLINATE tablets, it is important to act promptly. Symptoms may include nausea, vomiting, and gastrointestinal discomfort. Seek medical assistance immediately and provide the healthcare professional with information about the dosage taken. They will likely monitor vital signs and may administer supportive care to manage symptoms until the excess medication is cleared from the system. Quick action is key to minimizing potential health risks.

In the case of a missed dose of CALCIUM FOLINATE Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to proceed, as they may recommend adjusting your dosage or provide specific instructions to ensure the effectiveness of the treatment.

To take the CALCIUM FOLINATE Tablet, place the tablet on your tongue and allow it to dissolve, or swallow it whole with a glass of water, following the prescribed dosage and timing instructions provided by your healthcare professional.

Following are the conditions when CALCIUM FOLINATE Tablet should not be used:

• Should not be used in patients with a known allergy to folinic acid or any of its components.
• Not suitable for individuals with pernicious anemia, as it is not an effective treatment for this condition.
• Contraindicated in patients with untreated vitamin B12 deficiency, as it can mask the symptoms and lead to neurological damage.
• Should not be used to treat cancer without the supervision of a healthcare professional, as it may interfere with certain chemotherapy treatments.
• Not recommended for individuals with a history of allergic reactions to drugs containing PABA (para-aminobenzoic acid).
• Should be used with caution in patients with kidney disease, as dosage adjustments may be required.

The side effects of CALCIUM FOLINATE Tablet may include:

• Nausea and vomiting
• Diarrhea
• Loss of appetite
• Mouth sores or ulcers
• Skin reactions, such as rash or itching
• Allergic reactions, including hives and swelling
• Difficulty breathing or swallowing
• Increased sensitivity to sunlight

Following are the precautions and warnings for CALCIUM FOLINATE Tablet:

• This medication should not be used in patients with known hypersensitivity or allergy to calcium folinate or any of its excipients.
• It is crucial to monitor for signs of anaphylaxis, including breathing difficulties, hives, and swelling, especially during the initial administration.
• Patients with advanced liver disease may require dosage adjustments due to potential alterations in folate metabolism.
• Patients with a history of seizures should be closely monitored, as high doses of folate may lower the seizure threshold.
• Caution is advised in individuals with pernicious anemia, as it may mask the symptoms of vitamin B12 deficiency.
• Calcium folinate may interfere with certain laboratory tests, particularly those related to folate and vitamin B12 levels, so inform your doctor if you are undergoing any tests.
• It should be used with caution in patients with anemia caused by vitamin B12 deficiency, as it may lead to neurological deterioration.

Following are the drug interactions for CALCIUM FOLINATE Tablet:

• Prolonged use with phenytoin may lead to increased phenytoin serum levels and potential toxicity.
• May reduce the efficacy of methotrexate by inhibiting its activity.
• Anticonvulsants like phenobarbital, phenytoin, and primidone can decrease the effectiveness of CALCIUM FOLINATE by increasing its metabolism.
• Antibacterials such as trimethoprim and sulfamethoxazole can compete for renal tubular secretion, potentially increasing the risk of side effects.
• Proton pump inhibitors (PPIs) like omeprazole can decrease the absorption of CALCIUM FOLINATE, requiring monitoring and dose adjustments.
• Oral contraceptives containing estrogen may decrease the bioavailability of folic acid, which is a component of CALCIUM FOLINATE.
• Antifolate drugs (e.g., trimethoprim, pyrimethamine) may counteract the effects of CALCIUM FOLINATE, necessitating close monitoring.

Following are the food interactions for Calcium Folinate Tablet:

• Avoid consuming alcohol during treatment with Calcium Folinate as it may increase the risk of side effects and interfere with the medication's effectiveness.
• Folic acid levels can be reduced by certain foods like eggs, grapefruit juice, and some vegetables, so ensure a balanced diet to maintain optimal levels.
• Dairy products like milk, cheese, and yogurt may interfere with the absorption of Calcium Folinate, so consider separating medication and dairy intake by a few hours.
• High-fiber foods like whole grains, legumes, and certain vegetables can decrease the absorption of Calcium Folinate. Consider spacing out fiber intake and medication.
• Antacids containing calcium or magnesium can decrease the absorption of Calcium Folinate. Take antacids at least 2 hours before or after taking this medication.
• Vitamin C supplements can affect the metabolism of folic acid. Consult your healthcare provider for proper dosage and timing if taking both.
• Vitamin B12 deficiency can affect the effectiveness of Calcium Folinate. Ensure adequate B12 intake through diet or supplements as advised by your doctor.
• Certain medications, like phenytoin and methotrexate, can interact with Calcium Folinate. Inform your healthcare provider about all medications you are taking.

Calcium Folinate tablets should be stored in a cool, dry area, ideally at room temperature, ensuring protection from light and moisture. Maintain the tablets in their original packaging, securely sealed, to prevent contamination. Avoid exposing the medication to heat sources like radiators or stoves, as temperature fluctuations can impact its efficacy. Regularly check the expiry date, and if the tablets are past their prime or no longer needed, proper disposal is crucial. Refrain from discarding them in sinks or toilets; consult your pharmacist or healthcare professional for safe disposal methods. Lastly, keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Calcium Folinate Tablet:

• Adhere to the dosage prescribed by your doctor for the best therapeutic outcome.
• Swallow the tablet whole with a full glass of water for easier swallowing.
• Maintain a consistent daily routine for taking the medication to enhance its effectiveness.
• Avoid crushing or chewing the tablet; it's designed for whole ingestion.
• If you experience nausea, taking the tablet with food can help alleviate symptoms.
• Ensure you complete the full course of medication, even if you feel better before finishing.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.