RESOFT LOTION 110ML

Isotretinoin lotion works by influencing various cellular processes in the skin. Its primary mechanism of action involves binding to specific nuclear receptors called retinoic acid receptors (RARs). Upon binding to these receptors, isotretinoin regulates gene expression, leading to changes in cellular differentiation, proliferation, and apoptosis. It promotes the normalization of DNA synthesis and keratinization in the epidermis, helping to correct the abnormal differentiation characteristic of acne lesions. Isotretinoin also reduces the production of sebum by inhibiting the activity of sebaceous glands, which contributes to the reduction of acne symptoms. Additionally, it exhibits anti-inflammatory properties by modulating immune responses and decreasing the presence of pro-inflammatory mediators in the skin.

Aqua, Glycerin , Vitamin A, Lactic Acid

Retinoid.

Lotion

The following are the uses of Isotretinoin Lotion:

• Used for the treatment of severe acne that is resistant to other treatments.
• Used to reduce the appearance of acne scars and promote skin renewal.
• Used for managing acne in patients where other treatments have not been tolerated.
• Used to prevent the development of severe acne nodules and cysts.
• Used for improving skin texture and reducing skin oiliness.
• Used as a long-term solution to control acne and prevent future breakouts.
• Used in combination with other acne treatments for enhanced effectiveness.

In the case of an overdose of Isotretinoin Lotion, it is crucial to act promptly. First, contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the severity of the overdose. The immediate steps may include inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Quick action and medical advice are essential to mitigate potential health risks associated with an overdose.

In the case of a missed dose of Isotretinoin Lotion, it is important to act promptly. If you remember within a few hours of the missed application, apply the lotion as soon as possible. However, if a significant amount of time has passed or if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra lotion to make up for the missed dose, as this may increase the risk of side effects. It is best to consult your healthcare provider if you have any concerns or if you miss multiple doses.

To apply Isotretinoin Lotion, clean and dry the affected skin area, then apply a thin layer of the lotion once or twice daily, or as directed by your healthcare provider, gently rubbing it into the skin until it is absorbed.

Following are the conditions/situations when Isotretinoin Lotion should not be used:

• Do not use if you are allergic to any of the ingredients in the lotion.
• Should not be used by women who are pregnant or planning to become pregnant.
• Avoid using if you have severe kidney or liver disease.
• Not suitable for individuals with uncontrolled high cholesterol or triglyceride levels.
• Do not use if you have an active skin infection or severe skin conditions.
• Contraindicated in individuals with a history of severe depression or other psychiatric disorders.
• Should not be applied if you have an intolerance or sensitivity to any topical retinoids.
• Avoid using if you are currently taking other medications that may interact with Isotretinoin.

The side effects of Isotretinoin Lotion may include:

• Skin dryness, peeling, or itching
• Increased skin sensitivity to sunlight
• Redness or irritation at the application site
• Skin rash or hives
• Changes in skin color (darkening or lightening)
• Hair loss or thinning
• Nose bleeds
• Eye dryness or irritation

Following are the precautions and warnings for Isotretinoin Lotion:

• Avoid using Isotretinoin Lotion if you are pregnant or planning to become pregnant. It can cause severe birth defects or fetal death.
• Do not donate blood while using this medication and for at least 1 month after stopping treatment.
• Isotretinoin can cause severe skin reactions and sensitivity to sunlight. Avoid excessive sun exposure and use sunscreen.
• It may increase cholesterol and triglyceride levels, so regular monitoring is necessary.
• This medication can cause eye dryness and vision changes. Contact your doctor if you experience any eye-related symptoms.
• Do not use Isotretinoin Lotion with other retinoid medications or skin treatments without medical advice.
• Keep the lotion away from mucous membranes and avoid applying it near the eyes, mouth, and nose.

Following are the drug interactions for Isotretinoin Lotion:

• Avoid using other topical medications (e.g., benzoyl peroxide, tretinoin) at the same time as they may cause increased skin irritation.
• Isotretinoin may increase skin sensitivity to sunlight; avoid using photosensitizing drugs like certain antibiotics (tetracyclines) or thiazide diuretics.
• Concomitant use with vitamin A supplements should be avoided due to the risk of hypervitaminosis A.
• Oral retinoids, such as acitretin or other forms of isotretinoin, should not be taken simultaneously as this may lead to cumulative toxicity.
• Topical corticosteroids, if used with isotretinoin, may increase the risk of skin atrophy and other adverse effects.
• Some herbal supplements (e.g., St. John's Wort) may reduce the effectiveness of isotretinoin by accelerating its metabolism.
• Caution is advised when using isotretinoin with other medications that lower the seizure threshold, as this may increase the risk of seizures.

Following are the food interactions for Isotretinoin Lotion:

• Avoid Vitamin A-rich foods like liver, liver products, and supplements containing Vitamin A, as Isotretinoin can lead to excessive Vitamin A levels, causing potential toxicity.
• Reduce intake of foods high in saturated and trans fats, such as fried foods, fatty meats, and full-fat dairy, as these may increase the risk of elevated lipid levels, a known side effect of Isotretinoin.
• Limit the consumption of spicy foods as they may exacerbate skin sensitivity and irritation, a common side effect during Isotretinoin treatment.
• Avoid excessive alcohol consumption, as it may increase the risk of liver-related side effects and potentially interact with Isotretinoin's metabolism.
• Grapefruit and its juice should be limited, as they can affect the metabolism of Isotretinoin, potentially leading to increased drug levels in the blood.
• Ensure a balanced diet with adequate protein, complex carbohydrates, and healthy fats to support overall health and skin healing during treatment.
• Stay well-hydrated by drinking plenty of water, especially when experiencing dry skin and lips, which are common side effects of Isotretinoin.

Isotretinoin Lotion should be stored with care to ensure its effectiveness and safety. Keep the lotion in a cool and dry place, preferably at room temperature, and protect it from direct sunlight and moisture. Ensure the container is tightly sealed to maintain its integrity and prevent contamination. Do not expose the lotion to extreme temperatures, such as those found in bathrooms, near stoves, or radiators, as this can degrade the medication. Always check the expiration date, and if the lotion is past its prime, dispose of it responsibly; do not flush it down the toilet or pour it down the drain. Consult a pharmacist or healthcare provider for guidance on proper disposal methods, and keep the medication away from children to prevent accidental contact or ingestion.

Following are the quick tips for Isotretinoin Lotion:

• Wash your hands before and after applying the lotion to maintain hygiene.
• Apply a thin layer to the affected areas as directed by your dermatologist.
• Use only the prescribed amount; do not over-apply.
• Avoid applying the lotion on broken or irritated skin.
• Allow sufficient drying time after application before dressing.
• Do not share your medication with others, even if they have similar skin conditions.
• Store the lotion at room temperature, away from sunlight and moisture.