Revolade (25mg) 28 Tablets

Eltrombopag Olamine, at a dosage of 25mg, acts by stimulating the proliferation and differentiation of megakaryocytes, the bone marrow cells responsible for producing platelets. It achieves this by binding to the thrombopoietin receptor, a key regulator of megakaryocyte growth and development. This binding mimics the action of the natural hormone thrombopoietin, leading to increased production of platelets. By promoting the growth and maturation of megakaryocytes, Eltrombopag Olamine effectively enhances platelet counts, which is particularly beneficial in conditions where low platelet levels are a concern.

Eltrombopag Olamine 25mg

Thrombopoietin receptor agonist.

Tablet

The following are the uses of Eltrombopag Olamine 25mg Tablet:

• Used for treating low platelet counts in patients with chronic immune thrombocytopenia (ITP)
• Used to increase platelet count prior to surgeries or invasive procedures
• Used for managing low platelet counts caused by chronic liver disease
• Used to enhance platelet production in patients with severe aplastic anemia
• Used for thrombocytopenia caused by certain medications
• Used to reduce bleeding risks in patients with low platelets
• Used as part of a treatment regimen for certain blood disorders

In the case of an overdose of Eltrombopag Olamine 25mg Tablets, the severity of symptoms can vary. Individuals may experience nausea, vomiting, and abdominal pain. More serious effects could include liver toxicity, increased blood pressure, and fluid retention. It is important to seek medical advice promptly and provide healthcare professionals with details regarding the quantity ingested, as this information will assist in determining the necessary treatment approach.

In the case of a missed dose of Eltrombopag Olamine 25mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. It is important not to double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule. They will provide specific instructions based on your medical condition and treatment plan.

To take Eltrombopag Olamine 25mg Tablet, swallow the tablet whole with a full glass of water, preferably with food, once daily or as directed by your healthcare provider, following the dosage instructions provided.

Following are the conditions or circumstances when Eltrombopag Olamine 25mg Tablet should not be taken:

• Must not be used in individuals with a known allergy or hypersensitivity to Eltrombopag Olamine or any of its ingredients.
• Contraindicated in patients with severe liver disease or significant liver impairment.
• Not recommended for individuals with uncontrolled high blood pressure.
• Should be avoided in patients with a history of blood clots or thromboembolic events.
• Not suitable for women who are pregnant or breastfeeding.
• Must not be used in patients with active or recent gastrointestinal bleeding.
• Contraindicated in patients with a history of severe cardiac disease or uncontrolled arrhythmias.
• Avoid in individuals with a known platelet disorder or a history of platelet dysfunction.
• Not recommended for patients with active or recent cancer, especially blood-related cancers.

The side effects of Eltrombopag Olamine 25mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Abdominal pain
• Diarrhea
• Increased risk of blood clots
• Fatigue and weakness
• Skin rashes or itching

Following are the precautions and warnings for Eltrombopag Olamine 25mg Tablet:

• This medication should be used with caution in patients with a history of liver disease, as it may affect liver function.
• Regular monitoring of liver function is necessary, and any signs of liver problems should be reported to the doctor immediately.
• Eltrombopag Olamine can increase the risk of blood clots; patients with a history of blood clots or risk factors like obesity, smoking, or heart disease should be closely monitored.
• Patients should be aware of the signs of blood clots, such as leg pain, shortness of breath, and chest pain, and seek medical attention if they occur.
• Not recommended for individuals with a known allergy to Eltrombopag or any of its components.
• Elderly patients may be more sensitive to the side effects, so dosage adjustments might be required.
• It may cause dizziness or blurred vision, so patients should avoid driving or operating machinery until they know how this medication affects them.
• Women who are pregnant or breastfeeding should consult their doctor before taking this medication, as it may pose risks to the fetus or infant.

Following are the drug interactions for Eltrombopag Olamine 25mg Tablet:

• Concomitant use with mycophenolate mofetil may reduce the effect of Eltrombopag, potentially affecting platelet counts.
• Rifampin can significantly decrease Eltrombopag levels, reducing its effectiveness.
• Anticoagulants like warfarin may require dose adjustments when used with Eltrombopag due to potential changes in INR (International Normalized Ratio).
• Eltrombopag can increase the bioavailability of cyclosporine, requiring careful monitoring and possible dose adjustments.
• Co-administration with strong CYP1A2 inhibitors like fluvoxamine can increase Eltrombopag exposure, warranting close observation.
• Certain antiepileptic drugs (AEDs) like phenytoin, carbamazepine, and phenobarbital may decrease Eltrombopag levels, potentially reducing its therapeutic effect.
• The use of Eltrombopag with other drugs that affect platelet function or blood clotting should be closely monitored due to potential additive effects.

Following are the food interactions for Eltrombopag Olamine 25mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of Eltrombopag, potentially leading to increased drug levels in the blood and a higher risk of side effects.
• Alcohol intake should be limited or avoided as it can potentially increase the risk of liver-related side effects and may also reduce the effectiveness of Eltrombopag.
• High-fat meals can affect the absorption of Eltrombopag, possibly leading to variations in blood levels. It is advisable to maintain a consistent diet pattern when taking this medication.
• Avoid taking antacids containing aluminum or magnesium within 4 hours of Eltrombopag, as they can decrease its absorption.
• Vitamin E supplements should be used cautiously as they can increase the risk of bleeding when combined with Eltrombopag.
• Maintain a balanced diet rich in iron and vitamin B12 to support overall health and blood cell production.
• Stay hydrated by drinking adequate fluids, especially if you experience any gastrointestinal side effects like nausea or diarrhea.
• Certain herbal supplements, such as St. John's Wort, may affect the metabolism of Eltrombopag, so consult your healthcare provider before taking any herbal products.

Eltrombopag Olamine 25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, ensuring it is tightly sealed to maintain their integrity and prevent exposure to moisture or air. It is crucial to maintain a consistent room temperature, avoiding extreme heat or cold, as temperature fluctuations can impact the medication's effectiveness. Do not store the tablets in the bathroom or kitchen, where humidity and temperature changes are common. Always check the expiration date, and if the medication is expired or no longer needed, dispose of it responsibly. Proper disposal methods include returning it to a pharmacy or a designated medication disposal program, ensuring it is kept away from children and pets at all times.

Following are the quick tips for Eltrombopag Olamine 25mg Tablet:

• Take the tablet as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Eltrombopag is usually taken once daily with or without food.
• Maintain a consistent routine by taking the tablet at the same time each day.
• Do not miss any doses; if you accidentally miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor about all medications you are currently taking to ensure safe usage.
• Regular blood tests may be required to monitor your body's response to the medication.