Revolade (500mg) 28 Tablets

Eltrombopag Olamine, a thrombopoietin receptor agonist, stimulates megakaryocyte proliferation and differentiation, resulting in increased platelet production. It selectively activates the thrombopoietin receptor (c-Mpl), mimicking the action of the natural ligand, thrombopoietin. This activation triggers intracellular signaling pathways, including JAK-STAT, PI3K, and MAPK, which promote megakaryocyte maturation and platelet formation. Eltrombopag enhances the production of platelets by stimulating the proliferation and maturation of bone marrow cells responsible for platelet synthesis, thereby increasing platelet counts in patients with thrombocytopenia.

Eltrombopag Olamine 500mg

Thrombopoietin receptor agonist

Tablet

The following are the uses of Eltrombopag Olamine 500mg Tablet:

• Used for treating chronic idiopathic thrombocytopenic purpura (ITP), a blood disorder characterized by low platelet counts.
• Used to increase platelet counts in patients with severe chronic liver disease.
• Used to manage low platelet counts in patients with certain blood disorders or conditions affecting platelet production.
• Used to prepare patients for medical procedures, such as surgeries or dental work, by increasing platelet levels to reduce bleeding risks.
• Used for managing thrombocytopenia (low platelets) associated with certain cancers or their treatments.
• Used to support patients undergoing bone marrow transplantation by promoting platelet recovery.
• Used to enhance platelet production in patients with certain inherited platelet disorders.

In the case of an overdose of Eltrombopag Olamine 500mg Tablets, prompt medical attention is necessary. Symptoms of an overdose may include severe headaches, dizziness, and gastrointestinal issues such as nausea and abdominal pain. It is important to seek medical help immediately if you suspect an overdose, as healthcare professionals can provide the necessary treatment and support to manage any adverse effects. Quick action can help prevent potential complications.

In the case of a missed dose of Eltrombopag Olamine 500mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. It is recommended to take the missed dose within 12 hours of the scheduled time, but if more than 12 hours have passed, it is best to wait for the next scheduled dose. Consult your healthcare provider if you frequently miss doses or have concerns about the timing of your medication.

To take Eltrombopag Olamine 500mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, either with or without food, as directed by your healthcare professional.

Here are the conditions or situations when Eltrombopag Olamine 500mg Tablet should not be taken:

• Must be avoided by individuals with a known hypersensitivity or allergy to Eltrombopag Olamine or any of its excipients.
• Contraindicated in patients with severe liver disease or significant liver impairment.
• Not recommended for patients with a history of blood clots or thrombosis, as it may increase the risk of further clotting.
• Should not be used in individuals with active or recent gastrointestinal bleeding.
• Avoid in patients with a history of severe heart disease or uncontrolled hypertension.
• Contraindicated during pregnancy and breastfeeding, as it may harm the developing fetus or infant.
• Not suitable for individuals with a history of bone marrow disorders or blood cell production issues.

The side effects of Eltrombopag Olamine 500mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Abdominal pain
• Diarrhea
• Fatigue or weakness
• Skin rashes or itching
• Increased risk of blood clots

Following are the precautions and warnings for Eltrombopag Olamine 500mg Tablet:

• Not recommended for individuals with a history of hypersensitivity or allergic reactions to Eltrombopag or any of its excipients.
• Requires caution in patients with liver disease, as it may lead to further liver damage; regular monitoring of liver function is essential during treatment.
• Patients with a history of blood clots or thrombosis should be closely monitored, as the medication can increase the risk of clotting events.
• Not suitable for individuals with severe cytopenias, including anemia or neutropenia, unless closely monitored by a healthcare professional.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be necessary.
• Should be used with caution in patients with a history of cataracts, as it may increase the risk of cataract progression.
• Patients should be advised to promptly report any signs of liver problems, vision changes, or unusual bleeding/bruising during treatment.

Following are the drug interactions for Eltrombopag Olamine 500mg Tablet:

• Concomitant use with strong CYP1A2 inhibitors like fluvoxamine can increase eltrombopag concentrations, requiring dose adjustments.
• Avoid use with strong CYP2C8 inhibitors like gemfibrozil, as they may significantly increase eltrombopag exposure.
• Eltrombopag may reduce the effectiveness of hormonal contraceptives, requiring additional contraceptive methods.
• Rifampin, a strong CYP3A4 and CYP2C9 inducer, can decrease eltrombopag levels, potentially requiring eltrombopag dose adjustments.
• Theophylline levels may be reduced by eltrombopag, requiring monitoring and potential theophylline dose adjustments.
• May increase exposure of drugs metabolized by CYP2C9 (e.g., warfarin, phenytoin), requiring monitoring and dose adjustments.
• Eltrombopag may increase the risk of bleeding when taken with anticoagulants or antiplatelet agents.

Following are the food interactions for Eltrombopag Olamine 500mg Tablet:

• Avoid grapefruit and grapefruit juice as they can affect the absorption of Eltrombopag, leading to increased blood levels and potential side effects.
• Alcohol consumption should be limited as it may increase the risk of liver-related issues, especially when used long-term.
• High-fat meals may slightly decrease the absorption of Eltrombopag, but this effect is not clinically significant.
• Caffeinated beverages may potentially reduce the effectiveness of Eltrombopag, so consider reducing coffee, tea, or energy drink intake.
• Antacids containing aluminum or magnesium can decrease the absorption of Eltrombopag. Separate the intake of antacids and Eltrombopag by at least 4 hours.
• Vitamin K-rich foods like leafy greens may interfere with Eltrombopag's action on blood clotting. Consume these in moderation.
• Calcium-rich foods such as dairy products can also potentially interact with Eltrombopag. Separate calcium intake by a few hours.
• Stay well-hydrated to support overall health, especially if you experience gastrointestinal side effects.

Eltrombopag Olamine 500mg Tablets should be stored in a secure and dry location, maintaining a consistent room temperature. It is crucial to safeguard the medication from exposure to direct sunlight, moisture, and extreme temperatures. Keep the tablets in their original packaging, tightly sealed, to prevent contamination. Never store them in the bathroom or near heat-emitting appliances. Regularly verify the expiration date on the package, and if the medication is no longer needed or has expired, do not flush or pour it down the drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods. Additionally, ensure that the medication is stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Eltrombopag Olamine 500mg Tablet:

• Consult your doctor for personalized dosage instructions based on your medical condition.
• Take the tablet orally, preferably at the same time each day for consistent results.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Ensure you complete the full course of medication as prescribed, even if you feel better.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Regularly monitor your blood cell counts and liver function while on this medication.