REVOMET GEL 20G

Metronidazole gel's primary mechanism of action involves its ability to penetrate the skin and disrupt the DNA of susceptible anaerobic bacteria and protozoa. It is selectively taken up by these microorganisms, where it is then reduced by ferredoxin-mediated redox reactions. This reduction process generates toxic metabolites, particularly reactive oxygen species, which exert a cytotoxic effect by damaging the DNA structure of the microbes. This disruption of DNA synthesis ultimately leads to the inhibition of nucleic acid synthesis, thereby preventing the bacteria's growth and reproduction. This targeted action makes metronidazole gel an effective treatment for various skin conditions caused by anaerobic bacteria and certain protozoa.

Antiprotozoal / Antibacterial.

Gel

The following are the uses of Metronidazole Gel:

• Used for treating bacterial vaginosis, restoring healthy vaginal pH and flora.
• Used for reducing inflammation and discomfort in the vaginal area.
• Used for managing symptoms of rosacea, such as redness and acne-like breakouts.
• Used for treating acne, particularly in gel form, to reduce inflammation and kill bacteria.
• Used for healing wounds and preventing infections in certain cases.
• Used for maintaining intimate hygiene and preventing recurrent infections.
• Used for managing skin conditions like seborrheic dermatitis and perioral dermatitis.
• Used for providing symptomatic relief in various skin and vaginal infections.

In the case of an overdose of Metronidazole Gel, it is important to recognize that this medication is for topical use only. If ingested, it may cause adverse effects such as nausea, vomiting, and dizziness. Seek medical advice promptly and provide information on the amount ingested. Treatment may involve supportive care and monitoring, with the focus on managing symptoms and ensuring the well-being of the individual. It is crucial to follow the prescribed application instructions to prevent such incidents.

In the case of a missed dose of Metronidazole Gel, it is important to apply the gel as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed application. It is recommended to apply the gel at evenly spaced intervals to maintain its effectiveness. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed with your treatment.

To apply Metronidazole Gel, clean and dry the affected skin area, squeeze a small amount of the gel onto your fingertip, and gently rub it into the skin, ensuring even coverage, usually twice a day or as directed by your healthcare provider.

Following are the conditions or situations when Metronidazole Gel should not be used:

• Do not use if you have a known allergy or sensitivity to Metronidazole or other nitroimidazole derivatives.
• Avoid using Metronidazole Gel if you have a history of blood disorders or severe liver disease.
• Should not be used in individuals with a central nervous system disease, as it may exacerbate these conditions.
• Contraindicated in patients with a history of seizures or epilepsy.
• Do not use if you are currently taking disulfiram or have recently taken it.
• Not recommended for individuals with a history of peripheral neuropathy.
• Avoid using Metronidazole Gel if you have a yeast infection (candidiasis) in the affected area.
• Should not be used on open wounds or severe skin lesions.
• Contraindicated during the first trimester of pregnancy and in breastfeeding mothers.

The side effects of Metronidazole Gel may include:

• Skin irritation at the application site, such as redness, itching, or burning.
• Dry skin or peeling.
• Skin rash or hives.
• Stinging or tingling sensation.
• Swelling or inflammation.
• Unusual tiredness or fatigue.
• Headache or dizziness.
• Metallic taste in the mouth.

Following are the precautions and warnings for Metronidazole Gel:

• Avoid using the gel if you are allergic to Metronidazole or other similar antibiotics.
• Do not apply the gel near open flames or while smoking, as it may be flammable.
• Keep the gel away from your eyes, nose, and mouth to prevent irritation.
• Wash your hands thoroughly before and after applying the gel to avoid unnecessary exposure.
• Inform your healthcare provider if you have a history of liver or kidney disease before using Metronidazole Gel.
• Do not use this medication for longer than prescribed, and complete the full course of treatment.
• Avoid drinking alcohol while using Metronidazole Gel, as it may cause severe side effects.
• Discontinue use and seek medical attention if you experience severe skin reactions or other unusual symptoms.

Following are the drug interactions for Metronidazole Gel:

• Alcohol consumption should be avoided, as Metronidazole may cause a disulfiram-like reaction with alcohol, leading to nausea, vomiting, and flushing.
• Concurrent use with oral anticoagulants (e.g., warfarin) may increase the risk of bleeding due to Metronidazole's potential to enhance anticoagulant effects.
• Metronidazole may interact with lithium, increasing the risk of lithium toxicity by affecting its clearance.
• Use with phenytoin or phenobarbital may reduce the effectiveness of Metronidazole, as these drugs can increase its metabolism.
• Concurrent use with cimetidine may increase Metronidazole levels, potentially increasing the risk of side effects.
• Metronidazole can interact with certain chemotherapy agents (e.g., busulfan), leading to increased toxicity.
• The use of Metronidazole gel on areas of broken skin may lead to enhanced absorption, increasing the risk of systemic interactions.
• Use with disulfiram (used for alcohol dependence) should be avoided due to the increased risk of psychiatric reactions such as confusion and agitation.
• Topical corticosteroids or other topical medications may enhance the absorption of Metronidazole, increasing the risk of systemic side effects.

Following are the food interactions for Metronidazole Gel:

• Avoid consuming alcohol while using this medication, as it may cause a disulfiram-like reaction resulting in nausea, vomiting, flushing, and headaches.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the drug, potentially leading to increased side effects.
• Dairy products like milk and yogurt may reduce the absorption of Metronidazole, so it is advisable to take the medication at least an hour before or two hours after consuming dairy.
• Foods high in fat can potentially delay the absorption of Metronidazole, so it is recommended to take the medication on an empty stomach or with a low-fat meal.
• Avoid fermented foods like yogurt, cheese, and certain beverages, as they may contain small amounts of alcohol, which could interact with Metronidazole.
• Certain energy drinks and protein shakes may contain alcohol or ingredients that interfere with the medication's effectiveness.
• Avoid consuming large amounts of caffeine while on Metronidazole, as it may increase the risk of side effects like jitteriness and anxiety.
• Always follow your healthcare provider's instructions regarding specific dietary restrictions or recommendations during the course of treatment.

Metronidazole Gel should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. Ensure the tube is tightly sealed after each use to maintain its integrity and effectiveness. Do not store it in the refrigerator as extreme cold temperatures can alter the consistency of the gel. It is crucial to keep the gel away from children and pets to prevent accidental ingestion. When disposing of unused or expired Metronidazole Gel, do not throw it in the trash or pour it down the drain. Instead, contact your pharmacist or healthcare provider for guidance on proper disposal methods to minimize environmental impact.

Here are the quick tips for Metronidazole Gel:

• Clean and dry the affected area before applying the gel.
• Apply a thin layer of gel to the skin as directed by your doctor or pharmacist.
• Gently rub the gel into the skin, ensuring complete coverage of the affected area.
• Wash your hands after application, unless the hands are the treated area.
• Avoid applying the gel to broken or irritated skin.
• Do not cover the treated area with bandages or tight clothing.
• Complete the full course of treatment, even if symptoms improve before completion.