RHINOCORT AQUA (BUDESONIDE)

Budesonide syrup/suspension, when administered orally, acts locally in the airways to reduce inflammation. It is a corticosteroid that exhibits potent anti-inflammatory properties by binding to glucocorticoid receptors in the airways. Upon binding, budesonide inhibits the production and release of various inflammatory mediators, such as cytokines and leukotrienes, which are responsible for airway inflammation and bronchoconstriction. This mechanism helps to reduce airway hyperresponsiveness, decrease mucus production, and improve airflow, thereby alleviating symptoms associated with respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). The localized action of budesonide in the lungs minimizes systemic side effects, making it a preferred choice for long-term management of respiratory inflammation.

Budesonide

Glucocorticoid steroid.

Suspension

The following are the uses of Budesonide Syrup/Suspension:

• Used for treating inflammation and swelling in the airways of children with asthma.
• Used for managing symptoms like coughing, wheezing, and shortness of breath.
• Used to reduce airway inflammation and prevent asthma attacks in children.
• Used for the long-term management of asthma in children, helping to control symptoms.
• Used to improve lung function and overall asthma control in pediatric patients.
• Used for providing relief from asthma symptoms, allowing children to breathe easier.
• Used to minimize the need for rescue inhalers and reduce the frequency of asthma flare-ups.

In the case of an overdose of Budesonide Syrup/Suspension, several symptoms may manifest. These can include an increased heart rate, elevated blood pressure, and potential respiratory issues. Nausea, vomiting, and dizziness are also common. It is important to seek medical advice promptly, as appropriate treatment may involve inducing vomiting or administering activated charcoal to prevent further absorption. Timely intervention is key to managing potential complications.

In the case of a missed dose of Budesonide Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consult your healthcare provider for advice on how to improve your medication adherence and ensure the effectiveness of the treatment.

To take Budesonide syrup/suspension, shake the bottle well, then measure the prescribed dose using a dosing cup or oral syringe, and administer it orally once or twice daily as directed by your healthcare provider, ensuring the entire dose is taken without mixing it with other liquids.

Here are the situations when Budesonide Syrup/Suspension should not be used:

• Should not be given to children or infants who have a known allergy to Budesonide or any of the ingredients in the syrup/suspension.
• Contraindicated in patients with a fungal, bacterial, or viral infection in the area where the medication is to be used.
• Not suitable for individuals with active untreated tuberculosis.
• Should not be used if the patient is currently experiencing an asthma attack or severe breathing difficulties.
• Contraindicated in patients with a recent history of gastrointestinal perforation.
• Not recommended for individuals with severe liver disease.
• Should be avoided in patients with a history of hypersensitivity or severe allergic reactions to other corticosteroids.
• Do not use if the patient has untreated infections or systemic infections.

The side effects of Budesonide Syrup/Suspension may include:

• Throat irritation or dryness
• Hoarseness or changes in voice
• Cough or increased mucus production
• Nausea and vomiting
• Headache
• Stomach pain or discomfort
• Skin rashes or itching
• Fungal infections in the mouth or throat

Following are the precautions and warnings for Budesonide Syrup/Suspension:

• This medication should not be used in individuals with a known allergy or hypersensitivity to Budesonide or any of the excipients in the syrup.
• Budesonide can suppress the immune system, so caution is advised in patients with active infections. If an infection develops, medical attention should be sought.
• Long-term use of Budesonide may lead to adrenal suppression, especially in high doses. Regular monitoring of adrenal function is recommended.
• Patients with liver disease should be monitored closely as Budesonide is metabolized in the liver.
• Children's growth and development should be monitored regularly during prolonged treatment with Budesonide.
• Patients with a history of tuberculosis or exposure to tuberculosis should be closely monitored.
• Caution is advised when using Budesonide with other medications that can affect the immune system, as this may increase the risk of infections.
• If symptoms worsen or new symptoms appear, patients should consult their healthcare provider immediately.

Following are the drug interactions for Budesonide Syrup/Suspension:

• Ketoconazole and other strong CYP3A4 inhibitors can increase budesonide exposure, potentially leading to increased risk of adverse effects.
• Rifampin, a CYP3A4 inducer, may decrease the effectiveness of budesonide by increasing its metabolism.
• Concomitant use with clarithromycin, a strong CYP3A4 inhibitor, can result in elevated budesonide levels and potential side effects.
• The effect of budesonide may be reduced by enzyme inducers like carbamazepine, phenytoin, and rifabutin.
• Combining budesonide with ritonavir or cobicistat, CYP3A4 inhibitors, can increase budesonide concentrations and require dosage adjustments.
• Certain antifungal drugs, such as itraconazole and voriconazole, can inhibit budesonide metabolism, leading to increased drug levels.
• Caution is advised when using budesonide with other medications that have similar effects on the immune system, as it may increase the risk of infections.

Following are the food interactions for Budesonide Syrup/Suspension:

• Budesonide may interact with high-fat meals, delaying its absorption and reducing its effectiveness. Avoid consuming high-fat foods with this medication.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Budesonide, potentially increasing its levels in the body and the risk of side effects.
• Alcohol consumption can cause stomach irritation and may increase the risk of gastrointestinal side effects when taking Budesonide. It is advisable to limit or avoid alcohol during treatment.
• Dairy products like milk and yogurt can sometimes interact with Budesonide, potentially reducing its absorption. Consider separating the medication and dairy intake by a few hours.
• Avoid eating large meals immediately after taking Budesonide, as this may slow down the absorption and delay the onset of action.
• Certain fruits like bananas, avocados, and kiwifruit contain high levels of potassium, which may interact with Budesonide. Consult your doctor if you consume large amounts of these fruits regularly.
• Avoid spicy foods as they can irritate the stomach and potentially worsen gastrointestinal side effects associated with Budesonide use.
• Some vegetables like spinach and kale are rich in vitamin K, which can interact with Budesonide's blood-thinning effects. Maintain a consistent intake of these vegetables during treatment.

Budesonide Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication securely sealed in its original container to maintain its integrity and prevent contamination. Avoid storage in the bathroom or near heat-emitting appliances to prevent temperature-induced degradation. Regularly check the expiration date, and for proper disposal of unused or expired syrup, consult a pharmacist or healthcare professional, avoiding disposal by flushing or pouring into drains. Keep the medication safely stored away from children to prevent accidental consumption.

Following are the quick tips for Budesonide Syrup/Suspension:

• Consult your doctor for the correct dosage and duration of treatment.
• Administer the prescribed dose using the provided measuring device for accuracy.
• Ensure the syrup is well-mixed by gently shaking the bottle before each use.
• Take the syrup as directed, typically with a glass of water, and avoid consuming it with acidic beverages or dairy products.
• Maintain consistency by taking your doses at the same time each day.
• Store the syrup at room temperature, away from excessive heat, light, and moisture.
• Regularly monitor your symptoms and inform your doctor of any changes or side effects.