Rhinoff Forte (400/60mg) 100 Tablets

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This inhibition reduces the production of prostaglandins, which are involved in pain and inflammation signaling. As a result, ibuprofen helps alleviate pain, reduce inflammation, and lower fever. Pseudoephedrine, on the other hand, is a sympathomimetic amine that acts as a decongestant. It primarily stimulates alpha-adrenergic receptors in the nasal mucosa, causing vasoconstriction and reducing swelling and congestion in the nasal passages. This mechanism helps to relieve nasal congestion and promote easier breathing.

Ibuprofen, pseudoephedrine

NSAID, decongestant

Tablet

The following are the uses of Ibuprofen, pseudoephedrine Tablet:

• Used for relieving pain and reducing inflammation caused by conditions like arthritis, headaches, and minor injuries.
• Used to alleviate sinus congestion and stuffy nose due to colds or allergies.
• Used for reducing fever and managing mild to moderate pain.
• Used to treat symptoms of upper respiratory tract infections.
• Used to provide temporary relief from sinus pressure and headaches.
• Used to help ease discomfort from toothaches or minor dental procedures.
• Used to reduce swelling and ease discomfort after minor surgeries or procedures.
• Used to manage pain and inflammation associated with menstrual cramps.

In the case of an overdose of Ibuprofen and pseudoephedrine tablets, individuals may experience severe symptoms. These can include gastrointestinal issues such as nausea, vomiting, and stomach pain, as well as cardiovascular effects like increased heart rate and elevated blood pressure. Additionally, neurological signs such as dizziness, headache, and blurred vision might occur. Prompt medical intervention is necessary to manage these symptoms effectively and prevent potential complications. Timely treatment can ensure a better prognosis for patients who have overdosed on these medications.

In the case of a missed dose of Ibuprofen, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. For pseudoephedrine tablets, if you miss a dose, take it as soon as you remember, but avoid taking it near your next scheduled dose. You can resume your regular dosing schedule after the missed dose, ensuring you do not take more than the prescribed amount in a 24-hour period.

To take Ibuprofen and pseudoephedrine tablets, swallow the tablets whole with a full glass of water, preferably with food, following the dosage instructions provided by your healthcare professional, ensuring you do not exceed the recommended dose or duration of use.

Following are the conditions or situations when Ibuprofen, pseudoephedrine Tablet should not be used:

• Avoid using if you have a known allergy to Ibuprofen, pseudoephedrine, or any other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Do not take this medication if you have a history of heart attack, stroke, or severe heart-related issues.
• Contraindicated in individuals with severe high blood pressure or hypertension.
• Should not be used if you have a history of stomach bleeding, perforation, or ulcers.
• Not suitable for patients with severe kidney or liver disease.
• Avoid using if you have recently undergone heart bypass surgery (CABG).
• Do not take this medication if you have narrow-angle glaucoma.
• Contraindicated during the last stages of pregnancy.
• Should not be used by individuals with a history of seizures or epilepsy.
• Avoid using this medication if you have severe dehydration or low fluid volume.

The side effects of Ibuprofen, pseudoephedrine Tablet may include:

• Upset stomach, nausea, or vomiting.
• Dizziness or lightheadedness.
• Nervousness, restlessness, or trouble sleeping.
• Mild skin rash or itching.
• Increased heart rate or blood pressure.
• Ringing in the ears.
• Difficulty urinating.
• Fatigue or weakness.

Following are the precautions and warnings for Ibuprofen, pseudoephedrine Tablet:

• Not suitable for individuals with known allergies to ibuprofen, pseudoephedrine, or other NSAIDs.
• Patients with a history of stomach ulcers, bleeding disorders, or kidney problems should use with caution and under medical supervision.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Do not take this medication if you have untreated high blood pressure, severe heart-related problems, or if you have recently had a heart attack.
• This medication may cause dizziness; do not drive or operate heavy machinery until you know how it affects you.
• Pregnant women should consult their doctor before use, as it may affect fetal development.
• Not recommended for breastfeeding women, as ibuprofen can pass into breast milk.

Following are the drug interactions for Ibuprofen, pseudoephedrine Tablet:

• Ibuprofen may increase the risk of bleeding when taken with anticoagulants like warfarin, clopidogrel, or heparin.
• It can interact with other non-steroidal anti-inflammatory drugs (NSAIDs) and increase the likelihood of gastrointestinal issues and kidney problems.
• Pseudoephedrine may elevate blood pressure when combined with certain medications like MAO inhibitors (MAOIs) or other decongestants.
• Antihypertensive medications' effectiveness may be reduced by pseudoephedrine.
• Drugs metabolized by the liver, such as certain antidepressants or antipsychotics, may have increased blood levels when taken with Ibuprofen.
• Ibuprofen may decrease the efficacy of diuretics and ACE inhibitors.
• Concomitant use with lithium or methotrexate may increase the toxicity of these medications.

Following are the food interactions for Ibuprofen, pseudoephedrine Tablet:

• Grapefruit juice should be avoided as it may decrease the metabolism of pseudoephedrine, leading to increased side effects.
• Alcohol may increase the risk of gastrointestinal bleeding when taken with ibuprofen, and it can also increase the risk of cardiovascular side effects with pseudoephedrine.
• Caffeine-containing beverages should be limited as they can enhance the stimulant effect of pseudoephedrine and increase the risk of side effects like increased heart rate and blood pressure.
• Dairy products may reduce the absorption of pseudoephedrine, so it is advisable to separate them by at least 1-2 hours.
• High-fat meals can delay the absorption of ibuprofen, potentially reducing its effectiveness.
• Avoid spicy foods as ibuprofen may irritate the stomach lining, and spicy foods can exacerbate this effect.
• Consuming large amounts of vitamin C-rich foods might increase the reabsorption of oxidized pseudoephedrine, leading to potential side effects.
• Herbal teas, especially those containing St. John's Wort, should be used cautiously as they may interact with both ibuprofen and pseudoephedrine, affecting their effectiveness and increasing the risk of side effects.

Ibuprofen, pseudoephedrine tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. It's crucial to keep the medication in its original packaging, tightly sealed, to maintain its integrity. When disposing of unused or expired tablets, avoid flushing them down the toilet or sink. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices to prevent environmental contamination. Keep the medication out of children's reach to prevent accidental ingestion, and always exercise caution when handling and storing any pharmaceutical product. Proper storage and disposal practices contribute to the safe and responsible use of this medication.

Following are the quick tips for Ibuprofen, pseudoephedrine Tablet:

• Consult your doctor or pharmacist before use, especially if you have a medical condition or are taking other medications.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Take with or after food to minimize stomach irritation.
• Avoid alcohol consumption as it may increase the risk of side effects.
• Do not exceed the recommended dosage without medical advice.
• Store in a cool, dry place, away from direct sunlight.
• Discontinue use and seek medical attention if you experience severe headache, chest pain, or allergic reactions.
• This medication may cause drowsiness; do not drive or operate machinery until you know how it affects you.