Rhogam (300µg) 1 Vial Injection

Rho (D) Immune Globulin is a sterile solution made from human plasma. It contains antibodies that specifically target the Rho(D) antigen, which is found on Rh-positive red blood cells. The mechanism of action involves the passive transfer of anti-Rho(D) antibodies to the recipient. These antibodies bind to and neutralize any Rh-positive red blood cells that may have entered the maternal circulation, preventing the mother's immune system from mounting an immune response. This binding and clearance of Rh-positive cells inhibit the production of maternal antibodies, thereby preventing the potential sensitization that could lead to hemolytic disease in subsequent pregnancies.

Immune globulin

injection

The following are the uses of Rho (D) Immune Globulin injection:

• Used for preventing a potentially dangerous immune response in pregnant women who are Rh-negative
• Used to treat certain medical conditions like immune thrombocytopenia (ITP)
• Used to prevent Rh hemolytic disease of the newborn (also known as Rh disease)
• Used for treating an inherited disease called Thalassemia
• Used to treat an autoimmune disease called Idiopathic Thrombocytopenic Purpura (ITP)
• Used in cases of blood transfusion reactions
• Used to prevent complications during pregnancy and childbirth for Rh-incompatible mothers

In the case of an overdose of Rho (D) Immune Globulin injection, it is important to recognize that this medication is administered under medical supervision. While rare, potential side effects of an overdose may include allergic reactions, increased heart rate, and difficulty breathing. Prompt medical evaluation is necessary to address any adverse effects and provide appropriate supportive care. Treatment should focus on managing symptoms and ensuring the patient's well-being.

In the case of a missed dose of Rho (D) Immune Globulin injection, it is important to contact your healthcare provider as soon as possible. They will guide you on the appropriate course of action. Generally, a missed dose should be administered as soon as you remember, but if it's almost time for the next scheduled dose, it's best to skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one without consulting your doctor.

To administer the Rho (D) Immune Globulin injection, clean the injection site with alcohol, insert the needle at a 45-degree angle, inject the medication slowly, and after injection, apply pressure with sterile gauze for a few seconds, then cover the site with a bandage.

Here are the conditions or situations when Rho (D) Immune Globulin injection should not be administered:

• Do not use if the patient has a history of allergic reactions to human immune globulin or any component of the injection.
• Contraindicated in individuals with a history of severe systemic reactions to human immune globulin.
• Should not be used to treat immune thrombocytopenic purpura (ITP) or other autoimmune diseases.
• Not recommended for individuals with isolated O blood type.
• Avoid using if the patient has severe thrombocytopenia or anemia.
• Do not administer to individuals with a history of anaphylaxis.
• Not suitable for patients with a history of selective immunoglobulin A (IgA) deficiency.

The side effects of Rho (D) Immune Globulin injection may include:

• Headache
• Dizziness
• Nausea
• Vomiting
• Joint or muscle pain
• Mild fever
• Fatigue
• Injection site reactions (such as redness, swelling, or pain)

Following are the precautions and warnings for Rho (D) Immune Globulin injection:

• Do not administer if the patient has a history of severe allergic reactions to human immune globulin or any other components of the injection.
• Patients with a history of thrombosis or risk factors for thrombosis should be monitored closely, as the injection may increase the risk of blood clots.
• Ensure proper hydration before and after administration to prevent potential renal complications.
• Rho (D) Immune Globulin should be given with caution to individuals with a history of compromised cardiac function.
• It is essential to monitor patients for signs of anaphylaxis during and after the injection.
• This injection is intended for intramuscular use only; do not administer intravenously.
• Pregnant women should only use this medication if clearly needed and under medical supervision.

Following are the drug interactions for Rho (D) Immune Globulin injection:

• Concomitant use with live virus vaccines (e.g., measles, mumps, rubella, varicella) may reduce vaccine efficacy and increase the risk of adverse events.
• Other blood products or immune globulins may interfere with the effectiveness of Rho (D) Immune Globulin, leading to reduced response.
• Live, attenuated influenza vaccine (LAIV) should not be given within 2 weeks before or after Rho (D) Immune Globulin administration to avoid potential interference.
• Antibodies in the product may potentially interfere with the response to rabies vaccine, so a 3-month interval is recommended between them.
• When given with other parenteral products, separate administration sites and different infusion days are advised to ensure proper safety monitoring.
• Rho (D) Immune Globulin may interfere with diagnostic tests that employ passive agglutination techniques, potentially yielding false-positive results.
• Caution is advised when considering use with other drugs that affect the immune system, as the combined effects may be additive or synergistic.

Following are the food interactions for Rho (D) Immune Globulin injection:

• Avoid consuming alcohol as it may interfere with the medication's effectiveness and increase the risk of side effects.
• Stay hydrated and maintain adequate fluid intake, as proper hydration is essential during treatment.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the absorption of certain medications.
• Avoid high-fat meals as they can potentially delay or reduce the absorption of injectable medications.
• Avoid herbal supplements or natural remedies without medical advice, as some may interact with the injection.
• Follow a balanced diet rich in fruits, vegetables, and whole grains to support overall health during treatment.
• Consult your healthcare provider for personalized dietary recommendations based on your medical condition and treatment plan.
• Avoid extreme diets or restrictive eating patterns that may impact your nutritional status and recovery.

Rho (D) Immune Globulin injection requires specific storage and disposal instructions to maintain its efficacy and ensure safety. Store the injection in a refrigerator at 2-8°C (36-46°F), protecting it from freezing or excessive heat. Avoid exposure to direct sunlight and keep it in its original packaging to prevent contamination. Regularly check the expiration date, and do not use the injection if it has expired. For disposal, do not flush or pour it down the drain; instead, contact a healthcare professional or pharmacist for guidance on proper disposal methods. Keep the injection out of children's reach to prevent accidental exposure or ingestion. It is crucial to adhere to these guidelines to ensure the medication's integrity and minimize potential risks.

Following are the quick tips for Rho (D) Immune Globulin injection:

• Inform your doctor if you have any allergies, especially to human immune globulin or other medications.
• Disclose your complete medical history, including any blood disorders or immune system problems.
• Administer the injection as soon as possible after potential exposure to Rh-positive blood.
• Follow the healthcare provider's instructions for dosage and administration carefully.
• Avoid shaking the injection; gently swirl to ensure the solution is mixed well.
• Use a sterile syringe and needle for each injection to prevent contamination.
• Seek immediate medical attention if you experience any signs of an allergic reaction.