RIBUFEN 25G GEL

Ibuprofen gel exerts its analgesic and anti-inflammatory effects through the inhibition of cyclooxygenase (COX) enzymes, primarily COX-2. When applied topically, the ibuprofen molecules penetrate the skin and reach the underlying tissues where inflammation and pain occur. COX-2 is an enzyme responsible for the production of prostaglandins, which are key mediators of inflammation and pain. By blocking the action of COX-2, ibuprofen gel reduces the synthesis of prostaglandins, leading to decreased inflammation, reduced swelling, and pain relief in the targeted area. This localized mechanism of action allows for effective management of mild to moderate musculoskeletal pain and inflammation without significant systemic exposure to the medication.

Ibuprofen

Non-steroidal anti-inflammatory drug (NSAID).

Gel

The following are the uses of Ibuprofen Gel:

• Used for relieving muscular pain and stiffness, such as back pain, neck pain, or sprains.
• Used for reducing inflammation and swelling in joints, helping with conditions like arthritis.
• Used for treating sports injuries to ease pain and accelerate recovery.
• Used for headaches and migraines, providing localized pain relief.
• Used for reducing dental pain and discomfort, such as toothaches.
• Used for easing menstrual cramps and pelvic pain in women.
• Used for soothing minor burns and sunburn to reduce pain and inflammation.
• Used for managing post-surgical pain and discomfort as advised by healthcare professionals.

In the case of an overdose of Ibuprofen Gel, it is important to remain calm and seek assistance promptly. Symptoms may include stomach pain, nausea, and vomiting. Rinse the affected area with water to remove any remaining gel. Contact a healthcare professional or a poison control center for guidance on further treatment. They will provide advice on managing the overdose and may recommend specific steps to alleviate symptoms and ensure a safe recovery.

In the case of a missed dose of Ibuprofen Gel, it is important to apply the gel as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosage and ensure the treatment remains effective. It is recommended to create a routine to help you remember your medication schedule.

To apply Ibuprofen Gel, clean and dry the affected area, then gently massage a small amount of the gel onto the skin, following the instructions provided by your healthcare professional or the product label, typically applying it 3-4 times a day or as directed.

Here are the situations or conditions when Ibuprofen Gel should not be used:

• Do not use if you are allergic to ibuprofen or any other NSAID (Non-Steroidal Anti-Inflammatory Drugs) or have experienced asthma attacks, hives, or other allergic reactions after taking aspirin or other NSAIDs.
• Avoid using Ibuprofen Gel if you have a history of gastrointestinal bleeding or perforation.
• Not suitable for individuals with severe heart failure or kidney disease.
• Do not use on broken or infected skin.
• Contraindicated for individuals who have recently undergone heart surgery.
• Should not be used in individuals with a history of stomach ulcers or bleeding disorders.
• Avoid using Ibuprofen Gel if you are taking other medications that may increase the risk of bleeding, such as anticoagulants.
• Not recommended for children and adolescents under 18 years of age, except under medical supervision.
• Do not use Ibuprofen Gel if you are in the third trimester of pregnancy.
• Should not be used on areas of the body where there is a skin condition or inflammation, such as eczema or psoriasis.

The side effects of Ibuprofen Gel may include:

• Skin irritation or itching at the application site
• Redness or rash
• Mild burning or stinging sensation
• Dry skin or peeling
• Allergic reactions (hives, swelling, difficulty breathing)
• Increased sensitivity to sunlight
• Blistering or open sores

Following are the precautions and warnings:

• Ibuprofen Gel should not be applied to broken or infected skin, and should be kept away from eyes, mouth, and other mucous membranes.
• It is for external use only and should not be ingested or used on large areas of the body.
• Avoid using the gel on skin that is already irritated or on open wounds.
• Wash your hands thoroughly after applying the gel to avoid accidental contact with sensitive areas.
• If you are pregnant or breastfeeding, consult a healthcare professional before using Ibuprofen Gel.
• This product is intended for short-term use; prolonged use without medical advice should be avoided.
• If symptoms persist or worsen, or if you experience any unusual reactions, discontinue use and seek medical attention immediately.
• Keep out of reach of children and pets to prevent accidental ingestion or misuse.

Following are the drug interactions for Ibuprofen Gel:

• Ibuprofen Gel may interact with other non-steroidal anti-inflammatory drugs (NSAIDs), increasing the risk of gastrointestinal bleeding and ulcers.
• When used with oral anticoagulants, it can elevate the chances of bleeding.
• Aspirin and Ibuprofen Gel combination may result in reduced anti-platelet effect of Aspirin.
• The gel may interact with ACE inhibitors and ARBs, potentially reducing their effectiveness in controlling blood pressure.
• Lithium levels may be increased when used with Ibuprofen Gel, leading to toxicity.
• Ibuprofen Gel can potentially decrease the efficacy of diuretics, especially loop diuretics.
• Caution is advised with methotrexate as Ibuprofen Gel may elevate its plasma concentration.

Following are the food interactions for Ibuprofen Gel:

• Ibuprofen Gel can be used with most foods without any significant interactions, as the gel is applied topically and has minimal systemic absorption.
• Avoid eating or drinking products with high alcohol content immediately after applying the gel, as alcohol can increase skin irritation and may enhance the absorption of the medication.
• Grapefruit and grapefruit juice should be consumed with caution, as they can inhibit certain enzymes and potentially increase the effects of Ibuprofen, leading to an increased risk of gastrointestinal side effects.
• Spicy foods may cause skin sensitivity, and it's advisable to avoid them if you experience any irritation or discomfort after applying the gel.
• Dairy products are generally safe, but if you have a known dairy allergy or sensitivity, consult your healthcare provider before using the gel.
• Consuming a healthy diet rich in antioxidants and anti-inflammatory foods can complement the gel's effects and support overall pain management.
• Always wash your hands after applying the gel to avoid accidental ingestion, especially before handling or preparing food.
• Stay well-hydrated, as adequate fluid intake supports overall health and can aid in the body's natural healing processes.

Ibuprofen Gel should be stored carefully to maintain its effectiveness and safety. Keep it in a cool, dry place, preferably at room temperature, ensuring it's away from direct sunlight and moisture. It's crucial to store the gel in its original container, tightly sealed, to prevent contamination. Avoid extreme temperatures by not placing it near heat sources or in the bathroom, as this can impact its quality. Always check the expiration date, and if the gel is expired or no longer needed, proper disposal is essential. Do not dispose of it in drains or toilets; instead, seek advice from a pharmacist or healthcare professional for safe disposal methods, ensuring it is kept away from children to prevent accidental contact or ingestion.

Following are the quick tips for Ibuprofen Gel:

• Wash your hands before and after applying the gel to maintain hygiene.
• Apply a thin layer of gel to the affected area and gently rub it in until absorbed.
• Use the gel as directed by your healthcare professional for best results.
• Avoid applying the gel to broken or irritated skin; apply only to intact skin.
• Do not cover the treated area with airtight dressings or bandages, allow it to breathe.
• If you experience skin irritation, discontinue use and consult your healthcare provider.
• Store the gel at room temperature, away from direct sunlight and moisture.