RICH D TAB

Cholecalciferol, also known as vitamin D3, has a primary mechanism of action related to its role in calcium and phosphate homeostasis. When administered, cholecalciferol is converted in the liver to 25-hydroxycholecalciferol (calcidiol) and then further metabolized in the kidneys to its active form, 1,25-dihydroxycholecalciferol (calcitriol). Calcitriol acts as a hormone, binding to the vitamin D receptors (VDR) present in various target cells throughout the body. This binding activates the VDR, which then dimerizes with another nuclear receptor, leading to changes in gene expression. The primary effect is to increase the efficiency of calcium and phosphate absorption in the small intestine by stimulating the synthesis of calcium-binding proteins. This promotes bone mineralization and prevents conditions like rickets and osteomalacia by ensuring adequate levels of calcium and phosphate in the body. Additionally, cholecalciferol's active form has been found to have immunomodulatory and anti-inflammatory effects, influencing the expression of various immune-related genes.

Cholecalciferol

Vitamin D3 analog

Tablet

The following are the uses of Cholecalciferol Tablet:

• Used for treating and preventing Vitamin D deficiency, ensuring your body gets enough of this vital nutrient.
• Used for bone health, as it aids in calcium absorption, keeping your bones strong.
• Used to manage osteoporosis, reducing the risk of fractures.
• Used for individuals with limited sun exposure, ensuring Vitamin D production.
• Used to support immune function and overall well-being.
• Used for certain muscle disorders, improving muscle strength and function.
• Used in cases of kidney or digestive disorders, helping with nutrient absorption.
• Used to enhance mood and cognitive function, as Vitamin D plays a role in brain health.

The following dosage regimen is to be followed:

• Adults

The Recommended Dietary Allowance for adults is 600 IU daily

• Geriatric

The RDA for people 70 years or above is 800 IU daily

• Children

To be used as per doctor's recommendation

In the case of an overdose of Cholecalciferol Tablets, individuals may experience symptoms such as nausea, vomiting, weakness, and frequent urination. If a person ingests a large amount, it can lead to severe consequences like kidney damage, irregular heartbeat, and even death. It is crucial to seek medical assistance promptly if an overdose is suspected, as timely intervention can help mitigate potential health risks and prevent further complications. Medical professionals will provide the necessary treatment and support to manage the overdose effectively.

In the case of a missed dose of Cholecalciferol Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to resume your medication safely. It is recommended to set a daily reminder or use a pill organizer to help you remember to take your medication as prescribed.

To take Cholecalciferol Tablets, place the tablet on your tongue and swallow it with a glass of water, preferably with a meal or as directed by your healthcare professional, following the dosage instructions provided by your doctor or as indicated on the prescription label.

Here are the conditions and situations when Cholecalciferol (Vitamin D3) Tablet should not be used:

• Should not be used in individuals with a known hypersensitivity or allergy to Cholecalciferol or any of the excipients in the tablet.
• Contraindicated in patients with hypervitaminosis D, a condition where there are high levels of vitamin D in the body.
• Not recommended for individuals with hypercalcemia, which is elevated calcium levels in the blood.
• Should be avoided in patients with impaired kidney function or those on dialysis, as vitamin D metabolism can be affected.
• Not suitable for individuals with conditions causing calcium accumulation in soft tissues, such as sarcoidosis.
• Contraindicated during hyperparathyroidism, as it can worsen calcium and phosphate metabolism.
• Should not be used in patients with a history of kidney stones or conditions that increase the risk of calcium-based kidney stones.
• Not recommended for individuals with conditions causing excessive bone resorption, such as Paget's disease.

The side effects of Cholecalciferol Tablet may include:

• Nausea and vomiting
• Constipation or diarrhea
• Loss of appetite
• Dry mouth
• Metallic taste in the mouth
• Increased thirst and urination
• Muscle or joint pain
• Fatigue or weakness

Following are the precautions and warnings for Cholecalciferol Tablet:

• Cholecalciferol should be used with caution in individuals with a history of hypercalcemia, as it can increase calcium levels in the blood.
• Patients with a history of kidney stones or kidney disease should be monitored regularly as high doses of Cholecalciferol can increase the risk of kidney complications.
• This medication may not be suitable for individuals with a known allergy to vitamin D or any of its derivatives.
• Patients with conditions affecting vitamin D metabolism, such as sarcoidosis or hyperparathyroidism, should use Cholecalciferol under close medical supervision.
• Cholecalciferol can interact with certain medications like digoxin, thiazide diuretics, and steroids, so patients should inform their doctor about all the medications they are taking.
• Do not take more than the recommended dose, as excessive vitamin D can lead to serious side effects.
• Cholecalciferol may not be suitable for pregnant or breastfeeding women; consult your doctor for advice.
• Regular monitoring of calcium levels in the blood is necessary during long-term treatment with Cholecalciferol.

Following are the drug interactions for Cholecalciferol Tablet:

• Anticonvulsants like phenobarbital, phenytoin, and carbamazepine can reduce the effectiveness of cholecalciferol by increasing its metabolism.
• Cholestyramine and orlistat may decrease the absorption of vitamin D, potentially reducing its effectiveness.
• Thiazide diuretics can increase the risk of hypercalcemia when used with cholecalciferol, as they enhance calcium reabsorption.
• Calcium-containing antacids or calcium supplements may lead to hypercalcemia if taken with cholecalciferol.
• Concurrent use of digoxin and cholecalciferol may increase the risk of digitalis toxicity, requiring close monitoring of calcium levels.
• The absorption of cholecalciferol may be reduced by mineral oil, potentially affecting its effectiveness.
• Drugs that increase the metabolism of vitamin D, such as rifampin, can decrease cholecalciferol's effectiveness.

Following are the food interactions for Cholecalciferol Tablet:

• Avoid excessive consumption of foods rich in Vitamin D like fatty fish (salmon, mackerel), egg yolks, and fortified dairy products, as it may lead to Vitamin D toxicity.
• Maintain a balanced diet with adequate calcium and phosphorus intake, as these minerals work synergistically with Vitamin D for optimal bone health.
• Consuming Vitamin D supplements with a meal, especially one containing healthy fats, can enhance its absorption as it is a fat-soluble vitamin.
• Grapefruit juice should be consumed with caution as it may interfere with the metabolism of Vitamin D, leading to potential fluctuations in blood levels.
• Avoid excessive alcohol intake as it can impair the liver's ability to metabolize Vitamin D, affecting its overall effectiveness.
• Certain medications, such as corticosteroids and anti-seizure drugs, can interfere with Vitamin D metabolism, so consult your healthcare provider for any necessary adjustments.
• Some health conditions like kidney disease or fat malabsorption syndromes may require dietary modifications to manage Vitamin D levels effectively.
• Always follow the dosage instructions provided by your healthcare professional, as individual Vitamin D needs can vary.

Cholecalciferol Tablets should be stored in a cool and dry place, preferably at room temperature between 20-25°C (68-77°F). Protect the tablets from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and potency. It is crucial not to store them in the bathroom or kitchen, as these areas may have varying temperatures and humidity levels. Always check the expiration date on the packaging, and properly dispose of any unused or expired tablets. Do not dispose of them in regular household waste or flush them down the toilet; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for advice on safe disposal methods. Keep the medication out of the reach of children and pets to prevent accidental exposure.

No

Following are the quick tips for Cholecalciferol Tablet:

• Take the tablet as directed by your doctor, typically once a day or as prescribed.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Cholecalciferol can be taken with or without food, but taking it with a meal can help absorption.
• Maintain a consistent dosing schedule; try to take it at the same time each day.
• Do not double the dose if you miss a dose; continue with your regular schedule.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Consult your doctor if you are taking other medications to ensure safe use.