Rifadin (2%) 60ml Suspension

Rifampicin, the active ingredient in Rifampicin Syrup/Suspension, primarily acts by inhibiting bacterial RNA polymerase. It binds to the beta-subunit of the enzyme, which is crucial for RNA synthesis. This binding prevents the RNA polymerase from transcribing DNA into RNA, a critical process for bacterial replication and protein synthesis. Rifampicin's unique ability to target this enzyme makes it highly effective against rapidly growing bacteria, including Mycobacterium tuberculosis. By disrupting RNA synthesis, Rifampicin effectively halts bacterial growth and contributes to its bactericidal effect, making it a key component in the treatment of various bacterial infections.

anti-tuberculosis drug.

Suspension

The following are the uses of Rifampicin Syrup/Suspension:

• Used for treating bacterial infections, particularly tuberculosis.
• Used for its ability to kill or inhibit the growth of bacteria.
• Used in combination with other drugs for effective treatment.
• Used to prevent the spread of tuberculosis to others.
• Used for children and those who cannot swallow pills.
• Used as an alternative for patients with drug resistance.

In the case of an overdose of Rifampicin Syrup/Suspension, prompt medical attention is necessary. Symptoms may include severe nausea, vomiting, abdominal pain, and changes in urine color. The severity of the reaction depends on the amount ingested, and medical professionals should be informed about the quantity consumed. Treatment aims to provide supportive care, and managing symptoms may involve administering fluids and closely monitoring vital signs until the drug is eliminated from the body.

In the case of a missed dose of Rifampicin Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may advise you to restart the medication or adjust the dosage accordingly.

To administer Rifampicin Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or measuring cup, and take it orally once or twice daily as directed by your healthcare professional, preferably on an empty stomach, at least 30 minutes before or 2 hours after meals.

Following are the conditions when Rifampicin Syrup/Suspension should not be used:

• Do not take if you have a known allergy to Rifampicin or any other rifamycin antibiotics.
• Not suitable for individuals with liver disease or severe liver impairment.
• Contraindicated in patients with a history of severe allergic reactions to other medications.
• Should not be used if you have a history of porphyria (a disorder affecting the skin and nervous system).
• Avoid if you have a blockage in your intestines or any other conditions affecting the gut that may affect drug absorption.
• Not recommended for individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Do not use in patients with a history of acute liver injury or hepatitis after taking Rifampicin or similar medications.

The side effects of Rifampicin Syrup/Suspension may include:

• Nausea and vomiting
• Abdominal pain
• Diarrhea
• Loss of appetite
• Skin rash or itching
• Yellowing of skin and eyes (jaundice)
• Flu-like symptoms (fever, chills)
• Darkening of urine

Following are the precautions and warnings for Rifampicin Syrup/Suspension:

• Rifampicin should not be used in individuals with a known hypersensitivity or allergy to Rifampicin or any other rifamycin antibiotics.
• Regular monitoring of liver function is necessary during treatment, especially in patients with pre-existing liver conditions.
• This medication can cause discoloration of body fluids (e.g., urine, tears, sweat) which is usually temporary and harmless.
• Rifampicin can reduce the effectiveness of hormonal contraceptives; alternative methods of contraception are recommended.
• It may interact with several medications, including antiretroviral drugs, anticoagulants, and anticonvulsants, so a doctor should be informed of all current medications.
• Rifampicin can lead to bacterial resistance if not used properly, so it should be taken exactly as prescribed.
• Not recommended for use in children under 12 years old unless advised by a healthcare professional.
• Rifampicin may pass into breast milk; breastfeeding women should consult their doctor before use.

Following are the drug interactions for Rifampicin Syrup/Suspension:

• Rifampicin induces the metabolism of many drugs, reducing their effectiveness. This includes oral anticoagulants, oral hypoglycemic drugs, corticosteroids, digitalis, antiarrhythmic agents, and anticonvulsants.
• Concomitant use with antiretroviral protease inhibitors or non-nucleoside reverse transcriptase inhibitors should be avoided, as Rifampicin can significantly decrease their plasma concentrations.
• It may reduce the efficacy of hormonal contraceptives, requiring the use of alternative or additional contraceptive methods.
• Rifampicin can increase the metabolism of statins, potentially reducing their cholesterol-lowering effects.
• When taken with antifungal azole medications, Rifampicin may decrease their plasma concentrations, potentially reducing their effectiveness.
• It can accelerate the elimination of several antidepressants, including selective serotonin reuptake inhibitors (SSRIs), requiring dosage adjustments.
• Rifampicin may decrease the effectiveness of antiarrhythmic agents like mexiletine and propafenone, necessitating close monitoring.

Following are the food interactions for Rifampicin Syrup/Suspension:

• Avoid grapefruit and grapefruit juice as they can decrease the effectiveness of Rifampicin by altering its metabolism, leading to reduced drug levels in the body.
• Alcohol consumption should be limited as Rifampicin can increase the effects of alcohol, causing increased drowsiness and sedation.
• Dairy products like milk, cheese, and yogurt may reduce the absorption of Rifampicin; consider taking the medication at least 1-2 hours before or after consuming dairy.
• High-fat meals may also delay the absorption of Rifampicin; it is recommended to take the medication on an empty stomach or with a light meal.
• Vitamin K-rich foods like leafy green vegetables and liver may reduce the anticoagulant effect of Rifampicin, potentially affecting blood clotting.
• Rifampicin can cause discoloration of bodily fluids, including urine, sweat, and tears, which may temporarily stain contact lenses; consider removing lenses before taking the medication.
• Certain herbal supplements like St. John's Wort may reduce Rifampicin levels in the body, decreasing its effectiveness.
• Always maintain a consistent fluid intake to prevent dehydration, especially if Rifampicin causes increased sweating or urination.

Rifampicin Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect it from light and moisture by keeping the medication in its original container with the cap tightly sealed. Do not refrigerate or freeze the suspension as it may affect its potency. Always check the expiration date and dispose of any unused or expired medication responsibly. Avoid flushing or pouring it down the drain; consult a pharmacist or local waste disposal company for guidance on safe disposal practices. Keep the medication away from children and pets to prevent accidental consumption.

Following are the quick tips for Rifampicin Syrup/Suspension:

• Administer the prescribed dosage accurately using the provided measuring device.
• Ensure the syrup is well-mixed by shaking the bottle vigorously before each use.
• Encourage patients to take the medication at regular intervals to maintain consistent blood levels.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the suspension to prevent alteration of its properties.
• Check the expiration date regularly and discard any outdated medication safely.
• Inform your healthcare provider if you have any liver or kidney issues before taking this medication.