Rifin-E (150/75/275mg) 80 Tablets

The combination of Ethambutol, Isoniazid, and Rifampicin works synergistically to target and eliminate Mycobacterium tuberculosis. Ethambutol inhibits the synthesis of arabinogalactan, a key component of the mycobacterial cell wall, disrupting its integrity. Isoniazid interferes with mycolic acid synthesis, another vital component of the cell wall, leading to bacterial cell lysis. Rifampicin binds to and inhibits bacterial RNA polymerase, halting RNA synthesis and preventing bacterial replication. Together, these drugs effectively combat tuberculosis by attacking multiple essential processes in the mycobacterial cell.

Ethambutol, Isoniazid, Rifampicin

Anti-tuberculosis and Antibiotic

Tablet

The following are the uses of Ethambutol, Isoniazid, Rifampicin Tablet:

• Used for treating tuberculosis, specifically targeting the bacteria that cause TB.
• Used for halting the growth of TB bacteria in the body.
• Used for treating active pulmonary tuberculosis, ensuring the medication is taken for the full prescribed length of time.
• Used for preventing the development of resistance by combining with other TB medications.
• Used for managing latent tuberculosis infection, reducing the risk of the disease becoming active.
• Used for improving lung function and reducing symptoms in TB patients.
• Used for enhancing the effectiveness of other anti-TB drugs when used as part of a combination therapy.
• Used for achieving a successful treatment outcome by adhering to the prescribed dosage and duration.

In the case of an overdose of Ethambutol, Isoniazid, and Rifampicin Tablet, prompt medical attention is required. Symptoms may include nausea, vomiting, abdominal pain, and in severe cases, seizures or altered mental status. Treatment involves managing symptoms and providing supportive care. It is crucial to seek medical assistance immediately, as overdoses can lead to serious health complications and may require specific interventions based on the individual's condition.

In the case of a missed dose of Ethambutol, Isoniazid, and Rifampicin Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. For Ethambutol, if you miss a dose by more than 12 hours, skip the missed dose and continue with your regular dosing schedule. For Isoniazid and Rifampicin, take the missed dose as soon as possible, but do not double the dose.

To take the Ethambutol, Isoniazid, and Rifampicin Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, as directed by your healthcare professional. It is important to follow the prescribed dosage and schedule provided by your doctor, typically once daily, to ensure the effectiveness of the medication.

Here are the situations when Ethambutol, Isoniazid, Rifampicin Tablet should not be used:

• Do not use if you have a known allergy or hypersensitivity to any of the components Ethambutol, Isoniazid, or Rifampicin.
• This medication is contraindicated in patients with severe liver disease, as it can cause liver damage.
• Do not use if you have a history of optic neuritis or any visual impairment, as Ethambutol can affect the eyes.
• Not suitable for individuals with a history of severe kidney disease or kidney failure.
• Should not be used by individuals with a history of alcohol abuse or liver problems due to alcohol consumption.
• Contraindicated in patients with a history of acute gout, as it can trigger an attack.
• Do not use if you have a known deficiency of the liver enzyme acetylator.
• Not recommended for individuals with a history of epilepsy or other seizure disorders.
• Should be avoided in pregnant or breastfeeding women, as the components may cause harm to the fetus or infant.
• Do not use if you have a history of mental health disorders, as it may exacerbate symptoms.

The side effects of Ethambutol, Isoniazid, and Rifampicin Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Abdominal pain
• Darkened urine
• Skin rashes or itching
• Visual disturbances (e.g., blurred vision, color blindness)
• Joint pain and muscle weakness
• Fever and flu-like symptoms

Following are the precautions and warnings for Ethambutol, Isoniazid, Rifampicin Tablet:

• This medication is not recommended for individuals with known allergies or hypersensitivity to any of the active ingredients (Ethambutol, Isoniazid, Rifampicin) or other similar drugs.
• Regular monitoring of liver function is necessary, especially in patients with pre-existing liver conditions, as these drugs can affect liver enzymes.
• Patients should be aware of potential vision changes, and any visual disturbances should be reported to the doctor immediately.
• Ethambutol may cause peripheral neuropathy, so patients with pre-existing neuropathy should be monitored closely.
• Rifampicin can reduce the effectiveness of hormonal contraceptives, so alternative contraceptive methods should be considered.
• Isoniazid can increase the risk of peripheral neuropathy, especially in elderly or malnourished patients, and those with pre-existing vitamin B6 deficiency.
• Patients should maintain adequate fluid intake to reduce the risk of kidney stones associated with Isoniazid.
• This medication may cause discoloration of body fluids, which is usually temporary and harmless.

Following are the drug interactions for Ethambutol, Isoniazid, and Rifampicin Tablet:

• Rifampicin can reduce the effectiveness of hormonal contraceptives, requiring alternative birth control methods.
• Concomitant use with antiretroviral drugs for HIV may require dosage adjustments due to potential interactions.
• Isoniazid may increase the risk of side effects when taken with acetaminophen, phenytoin, or disulfiram.
• Ethambutol can decrease the efficacy of live vaccines, so vaccination schedules should be adjusted accordingly.
• The tablet may affect the metabolism of anticoagulants, requiring close monitoring of blood clotting parameters.
• Rifampicin can induce the metabolism of many drugs, leading to decreased blood levels and reduced effectiveness.
• It may also interact with antidiabetic medications, necessitating careful glucose monitoring.

Following are the food interactions for Ethambutol, Isoniazid, and Rifampicin Tablet:

• Avoid consuming excessive amounts of tyramine-rich foods like aged cheeses, cured meats, and certain types of beer, as Rifampicin can increase the risk of a tyramine-induced hypertensive crisis.
• Alcohol should be consumed in moderation, as Rifampicin may increase the effects of alcohol, leading to increased intoxication.
• Ensure adequate protein intake, as Rifampicin can increase protein requirements due to its effect on protein metabolism.
• Isoniazid may decrease vitamin B6 levels, so include vitamin B6-rich foods like poultry, fish, and whole grains.
• Ethambutol may decrease vitamin B12 absorption, so consider adding vitamin B12 supplements or foods rich in vitamin B12 like meat, dairy, and eggs.
• Avoid consuming foods with high salt content, as this may increase the risk of Isoniazid-induced hypertension.
• Maintain a balanced diet to support overall health and ensure optimal absorption of these medications.

Ethambutol, Isoniazid, and Rifampicin Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The tablets should be kept in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures or store it in the bathroom, as heat and humidity can impact its effectiveness. Proper disposal is essential; do not flush or pour the tablets down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods to avoid environmental contamination. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Ethambutol, Isoniazid, Rifampicin Tablet:

• Take the tablet as directed by your doctor, typically once daily on an empty stomach.
• Ensure you complete the full course of medication, even if you feel better.
• Take the tablet with a full glass of water to aid swallowing.
• Avoid alcohol consumption as it may interfere with the medication's effectiveness.
• Inform your doctor if you have any liver or kidney issues before starting this medication.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Regularly monitor your liver function and vision during treatment.