RILUTEK 50MG TAB (RILUZOLE) IMP

Riluzole's primary mechanism of action is believed to involve the modulation of glutamate neurotransmission in the central nervous system. It preferentially blocks voltage-dependent sodium channels in their open and inactive states, leading to a reduction in the release of glutamate, a key excitatory neurotransmitter. By inhibiting glutamate release, riluzole helps decrease excitotoxicity, which is thought to play a role in various neurological disorders. Additionally, riluzole may enhance the activity of inhibitory neurotransmitters like GABA and glycine, further promoting a more balanced excitatory-inhibitory neurotransmitter environment. This dual action is considered beneficial in managing conditions where glutamate dysregulation is implicated.

Antineurotic

Oral

The following are the uses of Riluzole 50MG Tablet:

• Used for treating amyotrophic lateral sclerosis (ALS), slowing down disease progression.
• Used to extend survival in ALS patients by reducing damage to motor neurons.
• Used to manage motor symptoms and improve muscle control in ALS patients.
• Used for alleviating respiratory distress and enhancing breathing capacity.
• Used for reducing fatigue and improving overall quality of life in ALS individuals.
• Used to potentially delay the need for mechanical ventilation in severe cases.
• Used for providing a supportive treatment approach in ALS management.

In the case of an overdose of Riluzole 50MG Tablets, it is important to recognize the potential severity of this situation. Symptoms may include nausea, vomiting, dizziness, and in extreme cases, seizures or difficulty breathing. Prompt action is necessary; contact a healthcare professional or poison control center immediately for guidance. They will provide specific instructions to manage the overdose, which may include supportive care and monitoring in a medical facility. Quick response and professional advice are crucial in such instances.

In the case of a missed dose of Riluzole 50MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication routine. It's crucial to maintain a consistent medication schedule, but if you encounter challenges, consult your healthcare provider for guidance.

To take Riluzole 50MG Tablet, swallow the tablet whole with a glass of water, usually twice a day (every 12 hours) or as directed by your doctor, and follow the prescribed dosage instructions provided by your healthcare professional.

Following are the conditions when Riluzole 50MG Tablet should not be taken:

• Should not be used in individuals with a known allergy to Riluzole or any of its ingredients.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Should not be used in individuals with respiratory impairment or severe respiratory disease.
• Not recommended for patients with a history of depression or suicidal thoughts.
• Avoid using Riluzole if you have a history of lung disease or breathing problems.
• Contraindicated in patients with a history of seizures or epilepsy.
• Should not be used during pregnancy or while breastfeeding.
• Not suitable for individuals with a history of kidney disease or kidney failure.
• Riluzole should not be taken if you have a history of heart disease or heart rhythm problems.

The side effects of Riluzole 50MG Tablet may include:

• Nausea and vomiting
• Fatigue and weakness
• Dizziness and lightheadedness
• Stomach pain or discomfort
• Diarrhea
• Loss of appetite
• Increased liver enzymes (detected in blood tests)
• Respiratory problems (shortness of breath, coughing)

Following are the precautions and warnings for Riluzole 50MG Tablet:

• Not recommended for individuals with known hypersensitivity or allergy to Riluzole or any of its excipients.
• Requires close monitoring of liver function and blood cell counts during treatment, and should be discontinued if abnormalities are detected.
• Caution is advised for patients with underlying liver or kidney disease, as dosage adjustments may be necessary.
• Patients should be aware of potential respiratory side effects and seek immediate medical attention if breathing difficulties occur.
• Riluzole may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for pregnant or breastfeeding women unless the potential benefits outweigh the risks.
• Should be used with caution in elderly patients, as they may be more susceptible to adverse effects.

Following are the drug interactions for Riluzole 50MG Tablet:

• Concomitant use with other medications that inhibit cytochrome P450 enzymes, such as CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin), can increase Riluzole plasma concentrations, potentially leading to increased side effects.
• Riluzole may decrease the effectiveness of oral contraceptives, so alternative methods of contraception are recommended.
• Taking Riluzole with antacids containing aluminum, magnesium, or simethicone may reduce the absorption of Riluzole, and thus these should be taken at least 2 hours apart.
• The effect of Riluzole may be reduced when taken with medications that increase stomach acidity, such as H2-receptor antagonists or proton pump inhibitors.
• Caution is advised when using Riluzole with other medications that lower the seizure threshold, as this may increase the risk of seizures.
• Riluzole can interact with other drugs metabolized by the liver, potentially affecting their blood levels, including certain antidepressants, antipsychotics, and anti-seizure medications.
• Riluzole may increase the concentration of medications that are substrates of P-glycoprotein, such as digoxin, potentially requiring dose adjustments.

Following are the food interactions to be aware of when taking Riluzole 50MG Tablet:

• Avoid consuming grapefruit or grapefruit juice as they can interfere with the metabolism of Riluzole, leading to increased drug levels in the body and potential side effects.
• Alcohol consumption should be limited or avoided as it may increase the risk of liver problems and enhance the sedative effects of Riluzole.
• Riluzole may cause a bitter taste, and consuming sweet foods or drinks might help mask this taste.
• Avoid high-fat meals as they can increase the absorption of Riluzole, potentially leading to higher drug concentrations in the body.
• Maintain a balanced diet to support overall health and ensure the medication's effectiveness.
• Certain foods rich in antioxidants, like berries and green leafy vegetables, may help protect against potential liver-related side effects.
• Stay hydrated by drinking adequate water to support kidney function while on Riluzole treatment.
• Avoid excessive caffeine intake as it may interact with Riluzole, potentially affecting its metabolism.

Riluzole 50MG Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in humid areas like bathrooms or near heat-emitting appliances to prevent degradation. Always verify the expiration date, and for proper disposal of unused or expired tablets, consult a pharmacist or healthcare professional. Do not dispose of them via toilet flushing or drainage systems. Keep the medication safely locked away from children to prevent accidental consumption.

Following are the quick tips for Riluzole 50MG Tablet:

• Consult a doctor for proper dosage and duration based on your medical condition.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Take it at the same time each day to maintain consistent blood levels.
• Do not stop taking the medication without consulting your doctor.
• Inform your doctor about all the medications you are currently taking.
• Avoid alcohol as it may increase the risk of liver damage.
• Regularly monitor liver function and blood cell counts as advised by your doctor.
• Store in a cool, dry place, away from direct sunlight and moisture.