Rimactal INH (150mg) 30 Tablets

Rifampicin 150mg Tablet primarily exerts its bactericidal effect through the inhibition of DNA-dependent RNA polymerase in susceptible bacterial cells. It binds to the beta-subunit of this enzyme, which is essential for the transcription of DNA into RNA. By doing so, Rifampicin blocks the initiation of RNA synthesis, preventing the production of essential proteins and RNA molecules necessary for bacterial survival and replication. This mechanism specifically targets RNA polymerase, disrupting the transcription process, and ultimately leads to the death of the bacteria.

Rifampicin, Antibiotic, Antituberculosis.

Tablet

The following are the uses of Rifampicin 150mg Tablet:

• Used for treating bacterial infections, particularly tuberculosis (TB).
• Used for its powerful bactericidal effect on rapidly growing TB bacteria.
• Used as a key component in combination therapy for effective TB treatment.
• Used to prevent the spread of TB by killing bacteria in the body.
• Used for treating severe bacterial infections like meningitis and endocarditis.
• Used for treating infections caused by staphylococcal and pneumococcal bacteria.
• Used as a second-line treatment for infections resistant to other antibiotics.
• Used to reduce the risk of infection in individuals with compromised immune systems.

In the case of an overdose of Rifampicin 150mg Tablets, symptoms may include nausea, vomiting, abdominal pain, and gastrointestinal bleeding. Prompt medical attention is necessary to manage the overdose effectively. Treatment may involve inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Medical professionals will also closely monitor vital signs and provide supportive care to ensure the patient's well-being. It is crucial to seek medical assistance immediately if an overdose is suspected.

In the case of a missed dose of Rifampicin 150mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to proceed, as they may recommend adjusting your dosing schedule or provide specific instructions for catching up on missed doses safely.

To take Rifampicin 150mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, following the dosage instructions provided by your healthcare professional, typically once or twice daily as directed.

Here are the conditions and situations when Rifampicin 150mg Tablet should not be taken:

• Avoid using Rifampicin if you have a known allergy or hypersensitivity to Rifampicin or any other rifamycin antibiotics.
• Do not take this medication if you have severe liver impairment or active liver disease.
• It is contraindicated in individuals with a history of jaundice or liver problems caused by previous Rifampicin use.
• Should not be used in patients with porphyria, a group of disorders affecting the skin and nervous system.
• Not recommended for individuals with a history of severe kidney disease or kidney failure.
• Avoid Rifampicin if you have an active infection caused by bacteria that are resistant to Rifampicin.
• Do not administer to infants below 2 months of age due to potential risk of liver toxicity.
• Contraindicated in individuals with a history of severe blood disorders or bone marrow suppression.

The side effects of Rifampicin 150mg Tablet may include:

• Skin rash or itching
• Fever
• Nausea and vomiting
• Loss of appetite
• Darkening of urine, tears, and sweat
• Yellowing of the skin or eyes (jaundice)
• Flu-like symptoms
• Joint pain

Following are the precautions and warnings for Rifampicin 150mg Tablet:

• Rifampicin may cause discoloration of body fluids, including urine, tears, and sweat, which is usually temporary and harmless.
• Regular monitoring of liver function is necessary during treatment, especially for patients with a history of liver disease.
• It can interfere with the effectiveness of hormonal contraceptives, so alternative birth control methods should be considered.
• Rifampicin may reduce the effectiveness of other medications, including antiretrovirals, anticoagulants, and oral diabetes medications.
• Patients should inform their doctor about all medications they are taking to avoid potential drug interactions.
• This medication should be used with caution in individuals with a history of kidney disease, as it is primarily eliminated through the kidneys.
• Rifampicin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding while taking this medication is not recommended due to the potential for serious adverse reactions in nursing infants.

Following are the drug interactions for Rifampicin 150mg Tablet:

• Rifampicin induces the metabolism of many drugs, including oral anticoagulants (e.g., warfarin), oral contraceptives, and antiretroviral medications, leading to reduced effectiveness of these drugs.
• It can decrease the efficacy of antiarrhythmic drugs like mexiletine and propafenone.
• Rifampicin may lower plasma concentrations of antimalarial drugs like chloroquine and quinine.
• The effectiveness of oral hypoglycemic agents (diabetes medications) may be reduced, requiring dosage adjustments.
• Anticonvulsants like phenytoin, carbamazepine, and sodium valproate may have decreased blood levels when taken with Rifampicin.
• It can reduce the plasma concentrations of antifungal drugs such as voriconazole and caspofungin.
• Rifampicin may decrease the therapeutic effects of corticosteroids, requiring close monitoring.

Following are the food interactions for Rifampicin 150mg Tablet:

• Avoid consuming high-fat meals while taking Rifampicin as it may affect the absorption of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Rifampicin, leading to potential drug interactions.
• Alcohol intake should be minimized or avoided as it may increase the risk of liver-related side effects, especially when used long-term.
• Avoid dairy products like milk, cheese, or yogurt within 2 hours before and after taking Rifampicin, as calcium can decrease its absorption.
• Vitamin K-rich foods like leafy greens may reduce the effectiveness of Rifampicin, so consume them in moderation.
• Iron supplements and iron-rich foods can also decrease Rifampicin absorption, so separate them by at least 2 hours.
• Ensure adequate fluid intake to prevent dehydration, especially if diarrhea occurs as a side effect.
• Consult your healthcare provider for personalized advice on dietary restrictions or adjustments.

Rifampicin 150mg Tablets should be stored in a cool and dry place, preferably at room temperature below 25°C (77°F). Protect the tablets from direct sunlight, moisture, and heat, as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air. It is crucial to dispose of any unused or expired medication properly, but never flush or pour the tablets down the drain. Consult your pharmacist or healthcare provider for appropriate disposal methods to ensure environmental safety. Always keep medications out of the sight and reach of children to prevent accidental consumption.

Following are the quick tips for Rifampicin 150mg Tablet:

• Take the tablet on an empty stomach, at least 30 minutes before or 2 hours after meals.
• Ensure you complete the full course of medication as prescribed.
• Drink plenty of fluids while taking this medication.
• Avoid taking antacids or indigestion remedies within 2 hours of taking the tablet.
• Store in a cool, dry place, away from direct sunlight.
• Inform your doctor if you have any liver or kidney problems before taking this medicine.
• Regular blood tests may be required to monitor liver function while on this medication.