Rintal (15mg/15mg) 120ml Syrup

Pholcodine and Promethazine HCl work synergistically in this syrup/suspension. Pholcodine acts as a cough suppressant by binding to opioid receptors in the brain, reducing the urge to cough. It effectively suppresses the cough reflex without affecting normal respiration. Promethazine HCl, an antihistamine, blocks histamine receptors in the brain and respiratory tract, reducing the severity and frequency of coughs. It also exhibits mild sedative properties, helping to calm the respiratory tract and alleviate the discomfort associated with coughing.

Antitussive/Antihistamine

Suspension

The following are the uses of Pholcodine 1.5mg, Promethazine HCL 1.5mg Syrup/Suspension:

• Used for suppressing dry, irritating, and painful coughs.
• Used to relieve symptoms of allergies and hay fever, such as runny nose, sneezing, and itching.
• Used to treat mild to moderate pain, including headaches, toothaches, and post-operative pain.
• Used to reduce nausea and vomiting associated with various conditions.
• Used as a pre-operative medication to reduce anxiety and induce mild sedation.
• Used for short-term relief of insomnia and to improve sleep quality.
• Used to manage symptoms of the common cold and flu, including cough and congestion.

In the case of an overdose of Pholcodine 1.5mg and Promethazine HCL 1.5mg Syrup/Suspension, symptoms may include severe drowsiness, confusion, respiratory depression, and in extreme cases, loss of consciousness. Prompt medical intervention is vital, as overdose can lead to life-threatening complications. Seek emergency medical care immediately, and provide healthcare professionals with details of the medication and the estimated amount ingested. Early treatment can help mitigate the risks associated with this overdose.

In the case of a missed dose of Pholcodine 1.5mg and Promethazine HCL 1.5mg Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to safely resume your medication.

To administer Pholcodine 1.5mg and Promethazine HCL 1.5mg Syrup/Suspension, shake the bottle well, measure the prescribed dose using the provided measuring cup or oral syringe, and take it orally as directed by your healthcare provider, typically once or twice a day, with or without food, following the dosage instructions provided.

Here are the conditions and situations when Pholcodine 1.5mg, Promethazine HCL 1.5mg Syrup/Suspension should not be used:

• Do not use if you have a known allergy or hypersensitivity to Pholcodine, Promethazine, or any other ingredients in the medication.
• Contraindicated in individuals with respiratory conditions such as severe asthma, respiratory depression, or lung diseases.
• Avoid use in patients with narrow-angle glaucoma or a history of glaucoma.
• Should not be used in patients with a history of seizures or epilepsy.
• Not recommended for individuals with prostate enlargement or urinary retention.
• Contraindicated in patients with severe liver or kidney disease.
• Do not use in children under 2 years of age, and use with caution in older children.
• Avoid using this medication if you have a blockage in the intestines or stomach.
• Should not be used in individuals with a history of porphyria.
• Contraindicated during breastfeeding, as it may pass into breast milk.

The side effects of Pholcodine 1.5mg and Promethazine HCL 1.5mg Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth
• Constipation
• Blurred vision or dizziness
• Nausea and vomiting
• Allergic reactions (skin rash, itching)
• Difficulty in urination
• Confusion or disorientation

Following are the precautions and warnings for Pholcodine 1.5mg, Promethazine HCL 1.5mg Syrup/Suspension:

• Do not consume this medication if you have a known allergy to Pholcodine, Promethazine, or any other ingredients in the syrup.
• Seek medical advice if you have a history of respiratory issues, such as asthma or chronic obstructive pulmonary disease (COPD), as Promethazine may cause respiratory depression.
• This medication can cause drowsiness and dizziness, so avoid driving, operating heavy machinery, or performing tasks that require mental alertness until you know how it affects you.
• Alcohol consumption should be avoided as it may enhance the sedative effects of Promethazine.
• Pholcodine should be used with caution in patients with kidney or liver problems, as it is primarily metabolized by these organs.
• Do not exceed the recommended dosage, as high doses of Pholcodine may lead to serious side effects, including respiratory depression and cardiac arrest.
• Children and elderly individuals should use this medication with caution and under medical supervision, as they may be more sensitive to its effects.
• Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Pholcodine and Promethazine may have potential risks during these periods.

Following are the drug interactions for Pholcodine 1.5mg, Promethazine HCL 1.5mg Syrup/Suspension:

• Alcohol and other central nervous system (CNS) depressants (e.g., benzodiazepines, opioids) can increase sedation and respiratory depression, potentially leading to serious adverse effects.
• Monoamine oxidase inhibitors (MAOIs) should be avoided due to the risk of serotonin syndrome and other severe reactions.
• Promethazine may enhance the sedative effects of other antihistamines, antidepressants, and antipsychotics.
• Pholcodine may interact with other opioids, increasing the risk of respiratory depression and overdose.
• Anticonvulsants and barbiturates may reduce the effectiveness of pholcodine.
• Drugs that prolong the QT interval, such as certain antiarrhythmics and antibiotics, should be used with caution due to the risk of cardiac arrhythmias.
• Promethazine may interfere with the absorption of live vaccines, potentially reducing their effectiveness.

Following are the food interactions for Pholcodine 1.5mg, Promethazine HCL 1.5mg Syrup/Suspension:

• Avoid consuming alcohol while taking this medication as it may enhance the sedative effects, leading to increased drowsiness and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of the medication, potentially altering its effectiveness.
• Caffeine-containing beverages like coffee, tea, or energy drinks might need to be limited as they can exacerbate restlessness and insomnia, which are possible side effects of Promethazine.
• Dairy products, particularly milk, may decrease the absorption of Pholcodine. Consider taking the medication at least 1-2 hours before or after consuming milk to maintain optimal absorption.
• Foods high in fat or a high-fat meal can slow down the absorption of Promethazine, potentially delaying its onset of action.
• Avoid eating large meals right after taking the medication, especially if it causes drowsiness or stomach upset as a side effect.
• Maintain a balanced diet to support overall health and ensure the medication's effectiveness.
• Always follow the advice of your healthcare provider regarding dietary considerations while using this medication.

Pholcodine 1.5mg and Promethazine HCL 1.5mg Syrup/Suspension should be stored in a secure and controlled environment, preferably in a locked cabinet or a designated storage area. Keep the medication away from direct sunlight, heat, and moisture, as these factors can degrade the quality of the suspension. Store it at room temperature, typically between 68°F and 77°F (20°C and 25°C), ensuring a consistent environment. Always keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. When disposing of the syrup, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe disposal methods. It is crucial to keep this medication out of the reach of children and pets to prevent accidental consumption.

Following are the quick tips for Pholcodine 1.5mg, Promethazine HCL 1.5mg Syrup/Suspension:

• Administer the syrup as directed by your doctor or pharmacist.
• Ensure you measure the correct dose using the measuring cup provided.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication.
• Always check the expiration date before use and discard if expired.
• Contact your healthcare provider if symptoms persist or worsen.
• Inform your doctor about any other medications you are taking to avoid potential interactions.
• Keep a record of your dosage timings to ensure you don't miss a dose.