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Rithmo XL (500mg) 5 Tablets
- Manufacturer SAMI Pharmaceuticals (Pvt.) Ltd.
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Generic Name
Clarithromycin 500mg
Healthwire Pharmacy Ratings & Reviews (1500+)
Product Information
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Description
Clarithromycin is a semi-synthetic macrolide antibiotic. It works by penetrating into bacteria cell wall and reversibly binding to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, in this way it blocks translocation of aminoacyl transfer-RNA and polypeptide synthesis, this mechanism results in inhibition of bacterial growth. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. Antibacterial spectrum of Clarithromycin is similar to erythromycin, but clarithromycin is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. Clarithromycin also shows bactericidal effects on certain strains like; Streptococcus pneumoniae, Haemophilus influenzae and Neisseria Gonorrhoeae. Clarithromycin is indicated for adults and children 12 years and older in children 6 months to 12 years pediatric oral suspension is available.
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Ingredients
Clarithromycin 500mg
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Dosage Form
Tablet
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Uses
Clarithromycin is utilized for the following therapeutic indications:
- Treatment of respiratory tract infections, including pneumonia and bronchitis
- Management of skin and soft tissue infections
- Treatment of Helicobacter pylori infection in peptic ulcer disease
- Treatment of sinusitis and pharyngitis
- Management of certain atypical infections
- Prevention of infections in immunocompromised patients
- Treatment of Lyme disease
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Dosage
Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: Extended release tablets must be given in adults in a dose of 500mg orally a day or 1000mg once a day. Doctor may adjust the dose according to patients condition like; For acute exacerbation of chronic bronchitis: 1000mg orally once daily for 7 days. For acute maxillary sinusitis: 1000mg orally once daily for 14 days. For community-acquired pneumonia: 1000mg orally once daily for 7 days.
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In case of Overdose
Consult your doctor in case of overdose.
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Missed Dose
In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.
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How To Use
Can be taken with or without food.
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When Not to Use
Prolonged release formulation must not be given in patients with renal impairment. Its use must be avoided during pregnancy and in breast feeding mothers. Should not be given to the patients who are hypersensitive to clarithromycin or any macrolide antibiotic.
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Side Effects
Headache Insomnia Skin rash Diarrhea Vomiting Abdominal pain Increased blood urea nitrogen Delayed blood clotting.
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Precautions & Warnings
Should be used with caution if a patient has some heart or liver disorders.
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Food Interactions
It may result in some unwanted effects with certain food, so take it according to your doctor’s instructions.
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Storage/Disposal
Store below 30°C. Protect from heat, sunlight.
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