Rithmo XL (500mg) 5 Tablets

Clarithromycin is a semi-synthetic macrolide antibiotic. It works by penetrating into bacteria cell wall and reversibly binding to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, in this way it blocks translocation of aminoacyl transfer-RNA and polypeptide synthesis, this mechanism results in inhibition of bacterial growth. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. Antibacterial spectrum of Clarithromycin is similar to erythromycin, but clarithromycin is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. Clarithromycin also shows bactericidal effects on certain strains like; Streptococcus pneumoniae, Haemophilus influenzae and Neisseria Gonorrhoeae. Clarithromycin is indicated for adults and children 12 years and older in children 6 months to 12 years pediatric oral suspension is available.

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Upper and Lower Respiratory Tract Infections, Skin and Soft Tissue Infections, Localized Mycobacterial Infections, in acid suppression, Mycobacterial Infections due to and Duodenal Ulcer disease to eradicate H. Pylori, Streptococcus Pneumoniae, Chronic Bronchitis, Haemophilus Influenzae, Pharyngitis/Tonsillitis due to Streptococcus, Haemophilus Influenzae, Moraxella Catarrhalis.

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Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: Extended release tablets must be given in adults in a dose of 500mg orally a day or 1000mg once a day. Doctor may adjust the dose according to patients condition like; For acute exacerbation of chronic bronchitis: 1000mg orally once daily for 7 days. For acute maxillary sinusitis: 1000mg orally once daily for 14 days. For community-acquired pneumonia: 1000mg orally once daily for 7 days.

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Consult your doctor in case of overdose.

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In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.

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Can be taken with or without food.

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Prolonged release formulation must not be given in patients with renal impairment. Its use must be avoided during pregnancy and in breast feeding mothers. Should not be given to the patients who are hypersensitive to clarithromycin or any macrolide antibiotic.

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Headache Insomnia Skin rash Diarrhea Vomiting Abdominal pain Increased blood urea nitrogen Delayed blood clotting.

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Should be used with caution if a patient has some heart or liver disorders.

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Store below 30°C. Protect from heat, sunlight.

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