Rivaro (15mg) 14 Tablets

Rivaroxaban is an anticoagulant that works by directly inhibiting factor Xa, a key enzyme in the coagulation cascade. It selectively blocks the active site of factor Xa, thereby preventing the conversion of prothrombin to thrombin and ultimately inhibiting the formation of blood clots. This mechanism of action is crucial in preventing the development of deep vein thrombosis (DVT) and pulmonary embolism (PE) by disrupting the coagulation process at a specific point, without the need for anticoagulant cofactors like antithrombin. The inhibition of factor Xa by rivaroxaban helps to maintain a balance between clot formation and the prevention of excessive blood clotting.

Oral anticoagulant.

Tablet

The following are the uses of Rivaroxaban 15mg Tablet:

• Used for preventing blood clots in patients who have had knee or hip replacement surgery.
• Used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevent them from recurring.
• Used for reducing the risk of stroke and blood clots in those with a type of irregular heartbeat called non-valvular atrial fibrillation.
• Used to prevent blood clots in individuals with limited mobility following an acute medical illness.
• Used for long-term prevention of blood clots in patients with a history of DVT or PE.
• Used for preventing blood clots in cancer patients who are at higher risk due to their cancer or treatment.
• Used for managing certain heart conditions, such as venous thromboembolism (VTE), to prevent serious cardiovascular events.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Rivaroxaban is a medication used to treat and prevent blood clots.
• The recommended dosage depends on the condition being treated.
• For the treatment of blood clots (DVT or PE) the initial dose is 15mg taken twice a day for 3 weeks, followed by 20mg once a day for the remaining treatment duration.
• For the prevention of blood clots in atrial fibrillation, the recommended dose is 20mg once a day.
• For the treatment and prevention of blood clots in patients who have undergone a knee or hip replacement, the recommended dose is 15mg taken twice a day for 10-14 days, followed by 20mg once a day.

In the case of an overdose of Rivaroxaban 15mg Tablets, it is important to recognize the signs and act promptly. Symptoms may include excessive bleeding, such as nosebleeds, bleeding gums, or easy bruising. If an overdose is suspected, seek medical advice immediately. Treatment may involve monitoring for bleeding complications and providing supportive care. Prompt action can help manage the risks associated with an overdose of this medication.

In the case of a missed dose of Rivaroxaban 15mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to adjust your dosing schedule or provide specific instructions for catching up on missed doses safely. It is crucial to maintain a consistent medication routine to ensure the effectiveness of the treatment.

To take Rivaroxaban 15mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, without crushing, chewing, or breaking it, as directed by your healthcare professional.

Following are the conditions when Rivaroxaban 15mg Tablet should not be used:

• Should not be used in individuals with active or uncontrolled bleeding problems.
• Contraindicated in patients with severe liver disease or liver impairment.
• Not recommended for individuals with a history of stroke or transient ischemic attack (TIA).
• Should not be used in patients with a recent history of spinal surgery or spinal anesthesia.
• Contraindicated in individuals with known or suspected malignant gastrointestinal lesions (e.g., stomach or intestinal cancer).
• Not suitable for patients with severe kidney disease or those on dialysis.
• Should be avoided in patients with antiphospholipid syndrome or other conditions that increase the risk of blood clots.
• Do not use if you have a known allergy to Rivaroxaban or any of its excipients.
• Not recommended for individuals with mechanical prosthetic heart valves.

The side effects of Rivaroxaban 15mg Tablet may include:

• Increased risk of bleeding, including nosebleeds, bleeding gums, or prolonged bleeding from cuts.
• Bruising easily.
• Headache and dizziness.
• Nausea and vomiting.
• Stomach pain or indigestion.
• Skin rash or itching.
• Fatigue and weakness.
• Elevated liver enzymes (liver function tests may be affected).

Following are the precautions and warnings for Rivaroxaban 15mg Tablet:

• Patients with known allergies to Rivaroxaban or any of its components should not take this medication.
• It should be used with caution in patients with liver or kidney disease, as dosage adjustments may be necessary.
• Patients undergoing spinal or epidural procedures, or those with a history of spinal injury or surgery, should be closely monitored for signs of spinal hematoma, a rare but serious side effect.
• Elderly patients may be more susceptible to bleeding risks, and regular monitoring is recommended.
• Avoid using Rivaroxaban in patients with active pathological bleeding or conditions that increase the risk of bleeding, such as stomach ulcers or bleeding disorders.
• This medication may need to be stopped temporarily before any surgical procedures to minimize bleeding risks.
• Patients taking Rivaroxaban should be advised to seek immediate medical attention if they experience any signs of abnormal bleeding, such as easy bruising, bleeding gums, or blood in the urine or stool.
• Women who are pregnant or breastfeeding should consult their healthcare provider before taking Rivaroxaban as its effects during these periods are not fully established.

Following are the drug interactions for Rivaroxaban 15mg Tablet:

• Anticoagulants like warfarin or heparin may increase the risk of bleeding when combined, requiring close monitoring of coagulation parameters.
• Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen can further elevate bleeding risks.
• Drugs affecting platelet function (e.g., clopidogrel, aspirin) may intensify bleeding tendencies.
• Antifungal medications like ketoconazole or itraconazole can increase Rivaroxaban levels, potentially requiring dose adjustments.
• Caution with strong CYP3A4 inhibitors (e.g., clarithromycin, ritonavir) as they may elevate Rivaroxaban concentrations.
• Rifampin, a strong CYP3A4 inducer, can reduce Rivaroxaban levels, possibly necessitating increased doses.
• Some herbal supplements, such as St. John's Wort, may decrease Rivaroxaban levels, impacting its effectiveness.

Following are the food interactions for Rivaroxaban 15mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they may interfere with the medication's metabolism, potentially increasing the risk of bleeding.
• Avoid cranberry juice as it can increase the effect of Rivaroxaban, leading to increased bleeding risk.
• Limit alcohol consumption as it can increase the risk of bleeding and may affect the effectiveness of the medicine.
• Green leafy vegetables like spinach, kale, and broccoli should be consumed in moderation as they are high in vitamin K, which can reduce the medication's anticoagulant effect.
• Avoid high-fat meals as they can increase the absorption of Rivaroxaban, potentially leading to higher blood levels of the drug.
• Maintain a consistent diet, especially with regards to vitamin K intake, as sudden changes can affect the drug's anticoagulant effect.
• Consult your healthcare provider for specific dietary recommendations and adjustments, especially if you have dietary restrictions or preferences.
• No significant food interactions have been reported to directly affect the absorption of Rivaroxaban, but it is always best to consult your pharmacist or doctor for personalized advice.

Rivaroxaban 15mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. Maintain the medication in its original packaging, ensuring the container is tightly sealed to prevent contamination. Avoid high temperatures and humidity, and never store the tablets in the bathroom or near heat sources. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not flush the tablets or throw them into the garbage; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption, and ensure responsible handling and storage at all times.

Following are the quick tips for Rivaroxaban 15mg Tablet:

• Consult your doctor before use, especially if you have kidney or liver problems, bleeding disorders, or upcoming surgeries.
• Take the tablet as directed by your doctor, usually once daily with or without food.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent daily routine for taking the medication.
• Avoid activities that may increase your risk of bleeding while on this medication.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the medication at room temperature, away from moisture and light.

Rivaroxaban is a medication used to treat and prevent blood clots. It is essential to have regular lab tests while taking this medication to monitor for any potential side effects or complications. Below is a summary of the essential laboratory investigations that are often required for individuals taking Rivaroxaban 15 mg, and the purpose of each test: