Rocaltrol (0.25mcg) 100 Capsules

Calcitriol, the active form of vitamin D, exerts its effects by binding to the vitamin D receptor (VDR) found in various target cells throughout the body. Upon binding, the calcitriol-VDR complex undergoes dimerization and interacts with specific DNA sequences in the nucleus, leading to the regulation of gene expression. This process primarily influences the absorption and metabolism of calcium and phosphorus in the intestine, kidneys, and bones. In the intestine, calcitriol enhances calcium and phosphate absorption by increasing the efficiency of transport systems. It promotes the synthesis of calcium-binding proteins and enzymes involved in calcium and phosphate homeostasis. Calcitriol also stimulates the release of calcium and phosphate from bones, contributing to the maintenance of serum calcium levels. Additionally, it regulates renal tubular reabsorption of calcium and phosphate, ensuring proper mineral balance in the body. The overall mechanism of action involves the modulation of gene expression, which ultimately affects calcium and phosphate metabolism, bone mineralization, and other physiological processes influenced by vitamin D.

Calcitriol

Vitamin D Analogue

Capsule

The following are the uses of Calcitriol Capsule:

• Used for treating calcium deficiency in conditions like hypoparathyroidism, where the body produces too little parathyroid hormone.
• Used for managing osteoporosis, helping to strengthen bones and reduce the risk of fractures.
• Used for supporting calcium absorption in the intestines, ensuring bones get the necessary mineral supply.
• Used for maintaining adequate levels of calcium and phosphate in the body, vital for overall health.
• Used for treating kidney diseases where calcium and phosphate imbalances occur.
• Used for managing rickets, a condition causing soft, weak bones in children due to vitamin D deficiency.
• Used for preventing and treating vitamin D deficiency, essential for bone health and immune function.
• Used for improving overall bone health and reducing the risk of bone-related diseases.

In the case of an overdose of Calcitriol Capsule, it is crucial to act swiftly. Symptoms may include nausea, vomiting, increased thirst, and frequent urination. If you or someone you know has taken an excessive dose, contact a healthcare professional or poison control center immediately. They will provide guidance on the necessary steps, which may include inducing vomiting or seeking emergency medical care to manage severe symptoms and prevent potential complications.

In the case of a missed dose of Calcitriol Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication regimen. It is essential to maintain a consistent routine with this medication for optimal effectiveness.

To take the Calcitriol Capsule, simply swallow the capsule whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, ensuring it is taken consistently as directed.

Here are the conditions and situations when Calcitriol Capsule should not be taken:

• Should not be used in individuals with a known hypersensitivity or allergy to Calcitriol or any vitamin D compounds.
• Contraindicated in patients with elevated calcium levels in the blood (hypercalcemia) or conditions that cause high blood calcium, such as hyperparathyroidism.
• Not recommended for individuals with vitamin D toxicity.
• Should be avoided in patients with kidney stones or a history of kidney disease, as it can increase calcium levels and worsen these conditions.
• Contraindicated in patients with a type of bone disease called osteomalacia, where bones become soft and brittle due to a problem with vitamin D metabolism.
• Should not be used in individuals with a condition called sarcoidosis, as it can increase calcium levels and lead to complications.
• Not suitable for patients with overactive parathyroid glands (primary hyperparathyroidism).
• Should be used with caution and under close medical supervision in individuals with heart disease, as it can affect calcium levels in the heart.

The side effects of Calcitriol Capsule may include:

• Nausea and vomiting
• Weakness or fatigue
• Headache
• Dry mouth
• Increased thirst and urination
• Constipation or diarrhea
• Muscle or joint pain
• Elevated calcium levels in the blood (hypercalcemia), which can lead to serious complications.

Following are the precautions and warnings for Calcitriol Capsule:

• Patients with known hypersensitivity or allergy to Calcitriol or any of its components should not take this medication.
• Regular monitoring of calcium levels in the blood and urine is essential during treatment, and dosage adjustments may be required based on these levels.
• Close monitoring of calcium and phosphate levels is crucial in patients with kidney impairment, as they are at higher risk of hypercalcemia.
• Patients with kidney stones or a history of kidney stones should exercise caution, as Calcitriol can increase the risk of stone formation.
• Caution is advised for individuals with metabolic bone diseases, as Calcitriol may affect bone metabolism.
• Elderly patients may be more susceptible to the side effects of Calcitriol, and dosage adjustments might be necessary.
• Pregnant and breastfeeding women should consult their doctor before taking Calcitriol, as it can impact fetal and infant calcium metabolism.

Following are the drug interactions for Calcitriol Capsule:

• Anticonvulsants like phenytoin, phenobarbital, and carbamazepine can decrease the effectiveness of Calcitriol by increasing its metabolism.
• Taking corticosteroids with Calcitriol may lead to increased calcium levels in the blood.
• The absorption of Calcitriol can be reduced by cholestyramine, a bile acid sequestrant.
• Thiazide diuretics such as hydrochlorothiazide may enhance the effects of Calcitriol, leading to hypercalcemia.
• Digitalis toxicity risk can be increased by Calcitriol due to elevated calcium levels.
• The effectiveness of calcium channel blockers, such as verapamil, may be reduced as Calcitriol can increase calcium levels.
• The combination of Calcitriol with other vitamin D analogs can result in additive effects and potential toxicity.

Following are the food interactions to consider with Calcitriol Capsule:

• Avoid consuming high-calcium foods like dairy products, calcium-fortified foods, and calcium supplements as they can increase calcium levels in the blood, leading to potential hypercalcemia.
• Grapefruit juice should be consumed with caution as it may affect the metabolism of Calcitriol, potentially raising its blood levels and increasing the risk of side effects.
• Limit vitamin D-rich foods like fatty fish, egg yolks, and liver as excessive intake can contribute to elevated vitamin D levels, which may lead to hypervitaminosis D.
• Alcohol may increase the risk of side effects such as kidney problems and high calcium levels, so it's best to limit or avoid alcohol consumption.
• Avoid or limit eating spinach, rhubarb, and sweet potatoes, as these foods contain oxalates, which can bind with calcium and form kidney stones.
• Avoid excessive caffeine intake, as it may interfere with calcium absorption and potentially affect bone health.
• Follow a balanced diet as instructed by your healthcare provider, ensuring adequate but not excessive intake of calcium and vitamin D.
• Always consult your healthcare provider or dietitian for personalized dietary advice when taking Calcitriol to ensure optimal health and medication effectiveness.

Calcitriol Capsules should be stored in a secure and dry location, preferably in a medicine cabinet, away from direct sunlight, moisture, and heat. Maintain a consistent room temperature, avoiding temperature fluctuations. Ensure the capsules are kept in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. Regularly check the expiration date, and dispose of any expired capsules promptly. When disposing of unused or expired medication, do not flush or pour them down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the capsules out of children's reach to prevent accidental consumption, as they can be harmful if ingested inappropriately.

Following are the quick tips for Calcitriol Capsule:

• Take the capsule as directed by your doctor, usually once a day.
• Swallow the capsule whole with a full glass of water, preferably at the same time each day.
• It can be taken with or without food, but taking it with food may reduce the risk of stomach upset.
• Do not crush, chew, or break the capsule; take it whole for optimal absorption.
• Avoid taking antacids or mineral supplements that contain magnesium, aluminum, or calcium within 2 hours of taking the capsule.
• Regularly monitor your calcium levels and kidney function while on this medication.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.