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GI upset, skin reactions, blood dyscrasias. Rarely pseudomembranous colitis, raised liver enzymes, glucosuria, oliguria, haematuria, bronchospasm, phlebitis at inj site, urinary and biliary precipitates, pancreatitis, nephrolithiasis, haemolytic anaemia, positive Coombs test.

Should be used with caution in patient with Severe renal and hepatic impairment. Do not use in pregnancy unless absolutely indicted. Monitor FBC during prolonged treatment. Non-severe hypersensitivity to other B lactams.

Adults: Usually 1 gm daily by deep IM, slow IV inj over at least 2-4 min, or IV infusion. Severe infections, 2-4 gm as a single dose every 24 hr. .Lower Respiratory Infection: Adults: IM/IV: Usual: 1-2 gm once daily (or in equally two divided doses). Max: 4 gm/day.