Roferon-A (3 MIU/0.5ml) 1 Pre-Filled Syringe Injection

Interferon Alpha Syringe works by stimulating the immune system and exhibiting antiviral properties. When administered, it binds to specific cell surface receptors, triggering a complex signaling cascade within the cell. This leads to the activation of various cellular processes, including the induction of antiviral proteins and enzymes. Interferon Alpha enhances the immune response by increasing the activity of natural killer cells, macrophages, and T lymphocytes, which help identify and eliminate infected cells. It also interferes with viral replication by inhibiting viral protein synthesis and disrupting viral replication cycles, thereby reducing the spread of the virus within the body. The mechanism involves upregulating the expression of genes involved in antiviral defense, ultimately leading to the inhibition of viral replication and the promotion of an antiviral state in cells.

Immunomodulators

Syringe

The following are the uses of Interferon Alpha Syringe:

• Used for treating certain types of cancer, particularly blood cancers like leukemia and lymphoma.
• Used for managing melanoma, a type of skin cancer, to slow its progression.
• Used for treating hepatitis B and C, helping the body fight off these viral infections.
• Used for reducing symptoms and slowing the progression of multiple sclerosis (MS).
• Used for treating HIV/AIDS, boosting the immune system to combat the virus.
• Used for managing kidney disease by reducing inflammation and improving kidney function.
• Used for certain autoimmune disorders to regulate the overactive immune response.

In the case of an overdose of Interferon Alpha Syringe, it is important to remain calm and seek medical advice promptly. Overdose symptoms may include severe flu-like symptoms, increased heart rate, and difficulty breathing. Contact a healthcare professional or poison control center for guidance, as they can provide specific instructions for managing the overdose and ensure appropriate medical care is administered. Timely action is vital for a positive outcome.

In the case of a missed dose of Interferon Alpha Syringe, it is important to follow the prescribed instructions carefully. If you realize you've missed a dose, administer it as soon as possible, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed.

To administer Interferon Alpha Syringe, twist the plunger to unlock, insert the needle subcutaneously, push the plunger to inject the medication, and then remove the syringe while applying pressure to the injection site if needed.

Following are the conditions when Interferon Alpha Syringe should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Interferon Alpha or any of its excipients.
• Contraindicated in patients with a history of severe depression or suicidal tendencies, as it can worsen these conditions.
• Not recommended for individuals with severe heart disease or recent heart attack due to the potential for cardiac side effects.
• Should not be used in patients with severe kidney disease, as it may require a dose adjustment.
• Contraindicated during breastfeeding, as it may harm the nursing infant.
• Not suitable for individuals with a history of epilepsy or seizures, as it can lower the seizure threshold.
• Should be avoided in patients with severe blood disorders or bone marrow suppression.

The side effects of Interferon Alpha Syringe may include:

• Flu-like symptoms such as fever, chills, headache, and muscle aches.
• Fatigue and weakness.
• Nausea, vomiting, and loss of appetite.
• Joint and muscle pain.
• Skin reactions at the injection site like redness, swelling, and pain.
• Hair loss or thinning.
• Depression, anxiety, and irritability.
• Changes in blood cell counts, which can lead to increased risk of infections or bleeding.

Following are the precautions and warnings for Interferon Alpha Syringe:

• Not recommended for individuals with a known hypersensitivity or allergy to Interferon Alpha or any of its excipients.
• Requires close medical supervision due to potential for severe side effects; regular monitoring of blood cell counts, liver function, and thyroid function is essential.
• Caution in patients with a history of depression or other psychiatric disorders, as it may exacerbate these conditions.
• Patients may experience flu-like symptoms; appropriate rest and supportive care should be provided.
• Not to be administered intramuscularly or subcutaneously; only for intravenous or subcutaneous use as directed.
• Should be used with caution in patients with pre-existing cardiac disease due to potential cardiac adverse effects.
• Interferon Alpha may cause birth defects; pregnant women should not use it, and effective contraception should be used during treatment.

Following are the drug interactions for Interferon Alpha Syringe:

• Avoid combination with ribavirin and telaprevir due to increased risk of adverse effects.
• Concomitant use with didanosine may lead to hepatic decompensation and pancreatitis.
• Interferon Alpha can enhance the anticoagulant effect of warfarin, necessitating close monitoring of INR.
• It may reduce the efficacy of live vaccines and increase the risk of adverse events.
• Use with zidovudine can result in increased hematologic toxicity.
• May interact with theophylline, causing elevated theophylline levels and potential toxicity.
• Caution is advised when combined with nucleoside reverse transcriptase inhibitors due to potential additive bone marrow suppression.

Following are the food interactions for Interferon Alpha Syringe:

• Alcohol consumption should be avoided or limited as it may increase the risk of liver toxicity and worsen side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of the medication, potentially increasing the drug's concentration in the body.
• Avoid high-fat meals as they may reduce the absorption of Interferon Alpha, leading to decreased effectiveness.
• Caffeine intake should be monitored as it can potentially interact with the medication, causing increased anxiety or nervousness.
• Avoid foods rich in Vitamin K (like spinach, kale) as Interferon Alpha may alter blood clotting, and these foods can interfere with this process.
• Maintain a balanced diet rich in lean proteins, whole grains, and fresh fruits/vegetables to support overall health during treatment.
• Stay hydrated by drinking plenty of fluids, especially water, to help manage potential side effects like nausea and dehydration.
• Consider dietary supplements as recommended by your healthcare provider to ensure adequate nutrient intake during treatment.

Interferon Alpha Syringe should be stored and disposed of with caution to ensure safety and maintain its integrity. Keep the syringe in a cool, dry place, preferably at room temperature, away from direct sunlight, heat, and moisture. Store it in its original packaging, tightly sealed, to prevent contamination. Always check the expiration date, and if the syringe is unused or expired, do not dispose of it by flushing or pouring it down the drain. Consult your pharmacist or healthcare provider for appropriate disposal methods to protect the environment. Keep the syringe out of children's reach to prevent accidental exposure and ensure proper handling.

Following are the quick tips for Interferon Alpha Syringe:

• Consult your healthcare provider for specific instructions regarding the injection procedure.
• Ensure the injection site is clean and dry before administering the medication.
• Inject the medication under the skin as directed, following the prescribed dosage.
• Rotate injection sites to minimize tissue irritation and discomfort.
• Dispose of used syringes safely in designated sharps containers.
• Store the medication as directed on the package; protect it from light and extreme temperatures.
• Report any unusual reactions or side effects to your healthcare provider promptly.