ROMICEF 500MG INJ

Cefpirome is a fourth-generation cephalosporin antibiotic that exerts its bactericidal effect by disrupting the synthesis of the bacterial cell wall. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking the peptidoglycan chains in the cell wall. By binding to PBPs, cefpirome inhibits the transpeptidation reaction, preventing the formation of a strong and stable cell wall. This leads to the weakening of the bacterial cell wall, resulting in cell lysis and eventual death of the bacteria. Cefpirome has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, including many resistant strains, by interfering with the final stages of cell wall synthesis.

Cefpirome 500MG

Cephalosporin antibiotic

Injection

The following are the uses of Cefpirome 500MG Injection:

• Used for treating severe bacterial infections like pneumonia and skin structure infections caused by susceptible bacteria.
• Used for the management of complicated urinary tract infections, ensuring a targeted approach to bacterial eradication.
• Effective against a range of gram-negative and gram-positive bacteria, providing broad-spectrum coverage.
• Helps prevent the progression of localized infections to more severe systemic conditions.
• Plays a role in the treatment of hospital-acquired infections, addressing the challenge of antibiotic-resistant bacteria.
• Used in combination with other antibiotics for synergistic effects, optimizing patient outcomes.

In the case of an overdose of Cefpirome 500MG Injection, immediate medical attention is necessary. Symptoms may include severe nausea, vomiting, and diarrhea, as well as potential neurological effects like seizures or confusion. The severity of these symptoms can vary depending on the individual and the amount ingested. Prompt medical intervention is vital to manage any adverse effects and ensure the patient's well-being. It is crucial to seek professional help and not delay treatment.

In the case of a missed dose of Cefpirome 500MG Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may need to adjust your dosage or provide further instructions.

To administer Cefpirome 500MG Injection, prepare the medication as directed by your healthcare professional, and inject the prescribed dose intramuscularly or intravenously, ensuring proper hygiene and aseptic techniques are followed during the administration process.

Following are the conditions when Cefpirome 500MG Injection should not be used:

• Must not be used in individuals with a known allergy to Cefpirome or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to penicillins, as there is a potential for cross-reactivity.
• Should not be administered to patients with a history of severe gastrointestinal diseases, especially colitis or antibiotic-associated diarrhea.
• Not recommended for individuals with a history of seizures or conditions that increase the risk of seizures, as it may lower the seizure threshold.
• Avoid using in patients with severe kidney impairment without adjusting the dose or monitoring closely.
• Not suitable for the treatment of viral infections, such as the common cold or flu.
• Should be avoided in patients with a history of severe or life-threatening hypersensitivity reactions to any beta-lactam antibiotic.

The side effects of Cefpirome 500MG Injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Headache
• Dizziness
• Increased liver enzymes
• Local pain or irritation at the injection site

Following are the precautions and warnings for Cefpirome 500MG Injection:

• Allergic reactions may occur; discontinue use and seek medical attention if signs of anaphylaxis or severe skin reactions appear.
• Cefpirome should be used with caution in patients with a history of allergies, especially to penicillins or other beta-lactam antibiotics.
• May cause diarrhea; prolonged or severe diarrhea should be reported to a healthcare professional as it could indicate a more serious condition.
• Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi.
• Monitor kidney function in patients with pre-existing renal impairment as dosage adjustments may be necessary.
• Use with caution in patients with a history of gastrointestinal diseases as it may aggravate these conditions.
• Safety and efficacy in children, pregnant and breastfeeding women are not established, consult a healthcare professional before use in these populations.

Following are the drug interactions for Cefpirome 500MG Injection:

• Probenecid can decrease the renal tubular secretion of cefpirome, potentially leading to increased plasma concentrations.
• Nephrotoxic drugs (e.g., aminoglycosides, colistin) may increase the risk of renal toxicity when used with cefpirome.
• The risk of bleeding or bruising may increase with non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulants.
• Cefpirome can reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Neuromuscular blocking agents may have their effects potentiated by cefpirome.
• Drugs that induce hepatic enzymes, such as rifampicin, may decrease cefpirome plasma concentrations.
• Cefpirome may interfere with certain lab tests, such as Coombs' test and glucose tests using glucose oxidase methods.

Following are the food interactions for Cefpirome 500MG Injection:

• Alcohol intake should be avoided as it may lead to increased dizziness, drowsiness, and potential complications with the effectiveness of the medication.
• Grapefruit and grapefruit juice consumption should be restricted as they can interfere with the metabolism of Cefpirome, leading to increased levels of the drug in the bloodstream and potential toxicity.
• Dairy products like milk, yogurt, and cheese should be consumed with caution as they may reduce the absorption of Cefpirome, affecting its effectiveness.
• Avoid high-fat meals as they can delay the absorption of Cefpirome, potentially reducing its therapeutic effect.
• Avoid caffeine as it may increase the risk of side effects, particularly nervousness and insomnia.
• Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health and recovery during the course of treatment.
• Stay well-hydrated by drinking adequate water to aid in the distribution and elimination of the medication.
• Avoid any known food allergies or intolerances to prevent adverse reactions while taking Cefpirome.

Cefpirome 500MG Injection should be stored in a cool, controlled environment, ideally between 20°C and 25°C (68°F and 77°F), ensuring it is protected from light and moisture. It is crucial to keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Do not freeze the medication as it may affect its potency. Always check the expiration date before use and dispose of any unused or expired injections according to local regulations and guidelines. Proper disposal is essential to prevent environmental harm, so do not discard it with regular household waste. Keep this medication out of the reach of children and pets to avoid accidental exposure.

Following are the quick tips for Cefpirome 500MG Injection:

• Administer the injection under medical supervision as directed by your doctor.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Cefpirome is typically given intravenously, so ensure the injection site is clean and sterile.
• Avoid rapid infusion; administer the injection over a recommended period of time.
• Report any signs of allergic reactions, such as rash, itching, or difficulty breathing, immediately.
• Store the injection as directed, usually at room temperature, away from direct sunlight.
• Do not use if the solution appears discolored or contains particles.