Ronim (500mg) 1 Injection/Infusion

Doripenem is a potent antibiotic belonging to the carbapenem class. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell death. Doripenem specifically binds to penicillin-binding proteins (PBPs), which are essential for cross-linking the peptidoglycan layer in bacterial cell walls. By irreversibly binding to these PBPs, Doripenem disrupts the transpeptidation and transglycosylation processes, preventing the formation of a robust cell wall. This results in the weakening of the cell wall and ultimately causes bacterial lysis. Doripenem is effective against a wide range of gram-negative and gram-positive bacteria, including those producing extended-spectrum beta-lactamases, by bypassing these resistance mechanisms and maintaining its antibacterial activity.

Doripenem 500mg

Carbapenem antibiotic.

Injection

The following are the uses of Doripenem 500mg injection:

• Used for treating complicated intra-abdominal infections, effectively targeting various bacteria causing these infections.
• Used for managing complicated urinary tract infections (UTIs), including those resistant to other antibiotics.
• Used for its effectiveness against a wide range of Gram-negative bacteria, including Pseudomonas aeruginosa.
• Used for its ability to penetrate well into various tissues and fluids, ensuring effective treatment.
• Used for the treatment of hospital-acquired pneumonia, providing a reliable option for severe cases.
• Used for its well-tolerated nature, with a lower risk of adverse effects compared to some other antibiotics.
• Used as a last-resort treatment option for severe infections when other antibiotics have failed.
• Used for its convenient dosing regimen, which may contribute to improved patient compliance.

In the case of an overdose of Doripenem 500mg injection, the primary concern is the potential for increased side effects and adverse reactions. Symptoms may include severe nausea, vomiting, diarrhea, and potential kidney issues. It is important to seek medical advice promptly, as treatment may involve supportive measures such as fluid therapy and monitoring of vital signs. Prompt recognition and management of an overdose can help prevent serious complications and ensure the patient's well-being.

In the case of a missed dose of Doripenem 500mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one. If you have missed multiple doses, consult your healthcare professional for advice on how to safely resume the medication without compromising its effectiveness. It is crucial to maintain a consistent dosing regimen for this medication.

To administer Doripenem 500mg injection, reconstitute the powder with the provided sterile water, gently swirl to dissolve, and inject the entire contents intravenously over a period of 4 hours, typically given every 8 hours as prescribed by your healthcare provider.

Following are the conditions/situations when Doripenem 500mg injection should not be used:

• Should not be used in individuals with a known allergy to Doripenem or other carbapenem antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to any beta-lactam antibiotics.
• Not recommended for patients with epilepsy or other seizure disorders.
• Should not be used in individuals with severe kidney impairment without adjusting the dosage.
• Contraindicated in patients with a history of Clostridioides difficile-associated diarrhea or colitis.
• Not suitable for those with a known sensitivity to any of the injection components.
• Doripenem should be avoided in patients with a history of Stevens-Johnson syndrome or toxic epidermal necrolysis.

The side effects of Doripenem 500mg injection may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Phlebitis (inflammation of the vein) at the injection site
• Seizures (in rare cases)
• Changes in liver function tests

Following are the precautions and warnings for Doripenem 500mg Injection:

• Patients with a known allergy to Doripenem or other carbapenem antibiotics should not receive this medication. Allergic reactions can be severe and immediate medical attention should be sought if symptoms like rash, itching, swelling, or difficulty breathing occur.
• Doripenem may lower the seizure threshold, so caution is advised in patients with a history of seizures or epilepsy. Close monitoring is necessary, and alternative treatments should be considered if seizures occur.
• Patients with kidney problems should be closely monitored as Doripenem is primarily eliminated through the kidneys. Dosage adjustments may be required in cases of renal impairment to prevent accumulation and potential toxicity.
• Doripenem may cause dizziness, confusion, or other central nervous system effects. Patients should exercise caution when performing tasks requiring alertness, and driving or operating machinery should be avoided if these symptoms occur.
• Elderly individuals may be more susceptible to the side effects of Doripenem, particularly neurological and renal effects. Careful dose selection and monitoring are essential in this population.
• Doripenem should be used during pregnancy and breastfeeding only if the potential benefits outweigh the risks. Animal studies have shown some adverse effects, and human data is limited. Consult a healthcare professional for personalized advice.
• Doripenem should be administered slowly, and patients should be closely monitored for infusion-related reactions such as fever, chills, or skin reactions. Appropriate medical management should be readily available to manage these reactions.

Following are the drug interactions for Doripenem 500mg injection:

• Probenecid can significantly increase the concentration of doripenem, potentially leading to enhanced side effects.
• Doripenem may reduce the effectiveness of valproic acid, requiring close monitoring of blood levels.
• Concomitant use with other antibiotics like vancomycin may increase the risk of seizures.
• Neuromuscular blocking agents can have their effects potentiated by doripenem, necessitating careful monitoring.
• The risk of bleeding may be elevated when using anticoagulants like warfarin alongside doripenem.
• Doripenem can decrease the efficacy of hormonal contraceptives, requiring the use of alternative birth control methods.
• Close monitoring is required when combining doripenem with medications that can cause kidney damage, such as nonsteroidal anti-inflammatory drugs (NSAIDs).

Following are the food interactions for Doripenem 500mg injection:

• Doripenem should be administered on an empty stomach. Avoid food and drinks for at least 2 hours before and after taking the medication to ensure optimal absorption.
• Grapefruit and grapefruit juice are known to interact with many medications, and Doripenem is no exception. Avoid consuming grapefruit products while on this medication as it can increase the drug's concentration in the body.
• Alcohol consumption should be limited or avoided as it may increase the risk of seizures and other central nervous system side effects associated with Doripenem.
• Dairy products like milk, cheese, and yogurt may decrease the absorption of Doripenem. It is recommended to wait at least 2 hours after taking the medication before consuming these items.
• High-fat meals can delay the absorption of Doripenem, so it is best to avoid large, fatty meals close to the time of medication administration.
• Caffeinated beverages such as coffee and tea may enhance the potential for seizures, especially when consumed in large quantities. It is advisable to limit caffeine intake while using Doripenem.
• Avoid eating or drinking anything that contains iron or other minerals (including multivitamins) as they can interfere with the effectiveness of Doripenem.
• Consult your healthcare provider for specific dietary recommendations during your treatment with Doripenem, as individual instructions may vary.

Doripenem 500mg injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from excessive heat, direct sunlight, and moisture by storing it in a cool, dry location. Always keep the medication in its original packaging, ensuring it remains tightly sealed to maintain sterility. Pay close attention to the expiration date, and never use the injection beyond this date. When disposing of unused or expired Doripenem injection, do not flush it down the toilet or pour it into a drain. Instead, follow local guidelines for the safe disposal of medical waste, or consult your pharmacist for appropriate disposal methods. Keep this medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Doripenem 500mg Injection:

• Doripenem injection should be administered by a healthcare professional for best results.
• Ensure the injection is prepared and stored as directed by the pharmacist.
• Inform your doctor if you have any allergies or kidney/liver problems before receiving the injection.
• Let your doctor know about all the medications you are taking to avoid potential interactions.
• It is common to experience mild pain, swelling, or redness at the injection site.
• Avoid missing doses; complete the full course as prescribed by your doctor.
• Seek immediate medical attention if you experience severe side effects like seizures or severe diarrhea.