Ropsol (0.05%) 10ml Eye Drops

Cyclosporin, the active ingredient in Cyclosporin Drops, primarily exerts its immunosuppressive effect by forming a complex with cyclophilin, a cytosolic protein found in T-lymphocytes. This drug-protein complex inhibits calcineurin, a calcium-dependent phosphatase enzyme. By blocking calcineurin, cyclosporin prevents the dephosphorylation and nuclear translocation of the nuclear factor of activated T cells (NF-AT), which is essential for the transcription of specific cytokine genes, such as interleukin-2 (IL-2). This inhibition suppresses T-cell activation and proliferation, thereby reducing the immune response in the targeted area.

Cyclosporin

Immunosuppressant

Drop

The following are the uses of Cyclosporin Drop:

• Used for treating dry eye disease, reducing inflammation and increasing tear production.
• Used for preventing corneal transplant rejection, ensuring the body accepts the new cornea.
• Used for managing severe keratitis, controlling inflammation and preventing scarring.
• Used for treating autoimmune conditions like Sjogren's syndrome, alleviating dry eye symptoms.
• Used for post-refractive surgery care, reducing inflammation and aiding healing.
• Used for corneal ulcer treatment, preventing infection and promoting healing.
• Used for managing graft-versus-host disease, reducing ocular symptoms.
• Used for controlling uveitis, suppressing inflammation in the eye.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Cyclosporine 0.05% is administered as drops for the treatment of anterior uveitis. The recommended dose is 1 drop in the affected eye every 12 hours.
• Cyclosporine 0.05% is administered orally for the prevention of transplant rejection in adults. The initial dose is 2.5 mg/kg/day divided bid daily, and the maintenance dose is 5-10 mg/kg/day divided bid daily.
• Cyclosporine 0.05% is applied topically as a cream or ointment for the treatment of psoriasis. The recommended dose is a small amount (about the size of a pearl) applied to the affected and surrounding skin areas, ensuring the area is no more than 10% of the total body surface area.
• Cyclosporine 0.05% is administered orally for the treatment of rheumatoid arthritis. The starting dose is 2.5 mg/kg/day divided bid daily or 3.75 mg/kg/day divided into 3 doses daily.

In the case of an overdose of Cyclosporin Drops, it is important to recognize the signs and act quickly. Symptoms may include nausea, vomiting, diarrhea, and increased blood pressure. If an overdose is suspected, seek medical advice immediately. Quick action can help prevent severe complications, as prompt treatment is crucial for managing the effects of excess Cyclosporin. Contacting a healthcare professional is essential for guidance and support.

In the case of a missed dose of Cyclosporin Drops, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the medication's effectiveness.

To administer Cyclosporin Drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper directly over the eye; release one drop into the pocket, blink gently to allow the drop to spread, and keep your eyes closed for 1-2 minutes to enhance absorption.

Following are the situations when Cyclosporin Drop should not be used:

• Must not be used if you have a known allergy or hypersensitivity to Cyclosporine or any of its ingredients.
• Not suitable for individuals with certain eye conditions like corneal endothelial cell density below the lower limit, uncontrolled or severe high eye pressure (glaucoma), or herpes viral infection of the eye.
• Contraindicated in patients with a history of eye surgery or eye trauma.
• Should not be used if you have a systemic infection or any active infection in the eye.
• Not recommended for individuals with a history of cancer or malignancy, especially skin cancer.
• Avoid using it if you have any immune system disorders or are taking medications that suppress the immune system.
• Do not use if you have a history of kidney disease or are receiving radiation therapy.

The side effects of Cyclosporin Eye Drops may include:

• Burning or stinging sensation in the eyes
• Eye redness or irritation
• Blurred vision
• Watery eyes
• Itchy eyes
• Sensitivity to light
• Headache

Following are the precautions and warnings for Cyclosporin Eye Drops:

• Avoid touching the dropper tip to any surface, including the eye, to prevent contamination.
• Do not wear contact lenses while using Cyclosporin eye drops, as they may absorb the medication.
• If you have any eye infection or injury, consult your doctor before using these drops.
• Inform your doctor about any other eye medications you are using to avoid potential interactions.
• Do not use the drops if the solution changes color or becomes cloudy.
• Cyclosporin eye drops may cause temporary blurred vision, so be cautious when performing tasks that require clear vision.
• If you have a history of eye problems or are undergoing eye surgery, inform your doctor as this medication may not be suitable.

Following are the drug interactions for Cyclosporin Drop:

• Cyclosporin can interact with other immunosuppressants like tacrolimus, increasing the risk of immunosuppression and infection. Close monitoring is necessary.
• The use of Cyclosporin with certain antibiotics such as erythromycin or clarithromycin can lead to increased Cyclosporin levels, potentially causing toxicity.
• It may interact with antifungal medications like ketoconazole, increasing Cyclosporin levels and the risk of adverse effects.
• Grapefruit juice should be avoided as it can inhibit Cyclosporin metabolism, leading to increased drug levels in the body.
• Cyclosporin may reduce the effectiveness of oral contraceptives, requiring alternative or additional contraceptive measures.
• The use of Cyclosporin with St. John's Wort (Hypericum perforatum) is not recommended as it can decrease Cyclosporin levels, reducing its therapeutic effect.
• Caution is advised when combining Cyclosporin with medications that affect the kidneys, as it may increase the risk of kidney impairment.

Following are the food interactions to be aware of with Cyclosporin Drops:

• Avoid consuming grapefruit and grapefruit juice as they can significantly increase Cyclosporin levels in the blood, leading to potential toxicity.
• Alcohol consumption should be limited as it may affect the metabolism of Cyclosporin, increasing the risk of side effects.
• Dairy products like milk, yogurt, and cheese can decrease the absorption of Cyclosporin, so it's best to separate their intake by at least 2 hours.
• High-fat meals can increase the absorption of Cyclosporin, potentially leading to elevated blood levels and increased side effects.
• Avoid pomegranate juice as it may slow down the breakdown of Cyclosporin in the body, increasing its levels and the risk of side effects.
• Do not consume licorice or products containing licorice root, as they can interfere with Cyclosporin metabolism, leading to increased blood levels.
• Inform your healthcare provider about all herbal supplements, as some may interact with Cyclosporin, affecting its effectiveness and safety.
• Always follow the advice of your healthcare professional regarding dietary restrictions and adjustments while using Cyclosporin Drops.

Cyclosporin drops should be stored in a cool, dry location, preferably at room temperature, away from direct sunlight, heat, and moisture. It is crucial to keep the drops in their original container, tightly sealed, to maintain their integrity and prevent contamination. Pay attention to the expiration date on the packaging and dispose of any unused or expired medication responsibly. Avoid flushing or pouring the medication down the drain; instead, seek advice from a pharmacist or healthcare professional on appropriate disposal methods. Always keep medicines out of children's reach to prevent accidental ingestion, and ensure that the storage area is secure and inaccessible to them. Proper storage and disposal practices are essential for the safe handling of Cyclosporin drops.

Following are the quick tips for Cyclosporin Drops:

• Wash your hands before administering the eye drops to ensure cleanliness.
• Tilt your head back, gently pull down your lower eyelid, and apply the prescribed number of drops into the eye.
• Close your eyes gently and tilt your head down for a few minutes to allow the drops to be absorbed.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If you wear contact lenses, remove them before using the drops and wait at least 15 minutes before reinserting them.
• Store the eye drops at room temperature, away from direct sunlight and moisture.
• Do not share your eye drops with others to prevent the spread of infection.

Cyclosporine is a medication that is used to suppress the immune system after organ transplants or for certain immune disorders. Taking cyclosporine requires regular monitoring of the patient's health, ensuring the medication is effective and doesn't cause any harm. Laboratory tests are an essential part of this monitoring, some of which include: