Rostin 100mg Tab

Rosuvastatin 100mg Tablet primarily works by inhibiting HMG-CoA reductase, a crucial enzyme responsible for catalyzing the conversion of HMG-CoA to mevalonate in the rate-limiting step of hepatic cholesterol synthesis. By blocking this enzyme, rosuvastatin significantly reduces cholesterol synthesis in the liver, leading to a decrease in the production of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol. This inhibition triggers an increase in hepatic LDL receptors, resulting in enhanced LDL uptake and clearance from the bloodstream. Consequently, rosuvastatin effectively lowers elevated total cholesterol and LDL cholesterol levels, while also modestly reducing triglyceride levels and raising high-density lipoprotein (HDL) cholesterol levels, thereby improving overall lipid profiles.

Statin (HMG-CoA reductase inhibitor)

Tablet

The following are the uses of Rosuvastatin 100mg Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood.
• Used to prevent cardiovascular events like heart attacks and strokes in high-risk patients.
• Used to manage conditions where there is an increased risk of heart and blood vessel problems.
• Used to slow down the progression of atherosclerosis (hardening of the arteries).
• Used to regulate lipid levels in patients with a family history of high cholesterol.
• Used to treat dyslipidemia, helping to reduce the risk of atherosclerosis development.
• Used as part of a comprehensive treatment plan to improve overall cardiovascular health.

In the case of an overdose of Rosuvastatin 100mg Tablets, it is important to seek medical assistance promptly. Overdosing on this medication may lead to an increased risk of liver damage, muscle pain, and in severe cases, rhabdomyolysis, a serious condition causing muscle breakdown. Symptoms of an overdose may include severe muscle pain, weakness, and dark-colored urine. It is crucial to contact a healthcare professional or poison control center for guidance on managing the overdose and to prevent potential long-term complications.

In the case of a missed dose of Rosuvastatin 100mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is generally recommended not to double the dose to make up for a missed one. If you frequently miss doses, inform your healthcare professional, and they may advise you on how to adjust your dosing schedule to ensure you receive the full benefit of the medication.

To take Rosuvastatin 100mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, either in the morning or in the evening, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Rosuvastatin 100mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Rosuvastatin or any other statin medications.
• Contraindicated in patients with active liver disease or persistently elevated liver enzymes.
• Not recommended for individuals with uncontrolled hypothyroidism.
• Should not be used during pregnancy or while breastfeeding.
• Avoid using if you have a history of muscle pain or weakness, especially if it was caused by previous statin therapy.
• Contraindicated in individuals with a genetic predisposition to muscle-related side effects from statins.
• Not suitable for patients with uncontrolled seizures or epilepsy.
• Should not be used in patients with a history of rhabdomyolysis (a serious muscle condition).
• Avoid using if you have recently had a major surgery or are scheduled for surgery.
• Not recommended for individuals with severe kidney disease or those on dialysis.

The side effects of Rosuvastatin 100mg Tablet may include:

• Muscle pain and weakness
• Joint pain
• Nausea and vomiting
• Constipation or diarrhea
• Abdominal pain
• Increased blood sugar levels
• Increased liver enzymes (liver function tests may be affected)
• Headache and dizziness

Here are the precautions and warnings for Rosuvastatin 100mg Tablet:

• Do not take this medication if you are allergic to Rosuvastatin or any other similar statin drugs.
• Inform your doctor if you have a medical history of liver disease, kidney disease, or diabetes as regular monitoring of liver enzymes and kidney function is necessary.
• Alcohol consumption should be avoided or limited while taking this medication as it may increase the risk of liver-related side effects.
• Patients with a history of muscle pain or weakness should exercise caution and report any unusual muscle symptoms immediately.
• This medication may cause harm to an unborn baby, therefore, it is important for women of childbearing age to use effective contraception while taking Rosuvastatin.
• Breastfeeding women should not take this medication as it may pass into breast milk and harm the nursing infant.
• Patients experiencing unexplained muscle pain, tenderness, or weakness should seek immediate medical attention as it may indicate a serious condition.
• Rosuvastatin can interact with other medications; inform your doctor about all the medications and supplements you are currently taking.

Following are the drug interactions for Rosuvastatin 100mg Tablet:

• Gemfibrozil may increase the risk of muscle-related side effects when used with Rosuvastatin, and their combination is generally not recommended.
• The use of Rosuvastatin with ciclosporin can increase the exposure to Rosuvastatin, potentially leading to increased side effects.
• Rosuvastatin may increase blood levels of warfarin, requiring closer monitoring of anticoagulation effects.
• When taken with fenofibrate, Rosuvastatin may slightly increase the risk of muscle-related side effects.
• The effectiveness of hormonal contraceptives may be reduced when used with Rosuvastatin, requiring alternative or additional contraceptive methods.
• Combining Rosuvastatin with fibrates, niacin, or colchicine can increase the risk of muscle-related side effects.
• Caution is advised when using Rosuvastatin with other medications that can increase the risk of myopathy or rhabdomyolysis, such as certain antibiotics and antifungals.

Following are the food interactions for Rosuvastatin 100mg Tablet:

• Avoid consuming excessive amounts of grapefruit or grapefruit juice as it can increase the levels of the medication in the blood, potentially leading to an increased risk of side effects.
• Limit alcohol consumption as it can raise the risk of liver-related issues and may interact with the medication, affecting its effectiveness.
• Avoid high-fat and high-cholesterol diets; Rosuvastatin is most effective when combined with a healthy diet, helping to lower cholesterol levels.
• Avoid large amounts of red yeast rice in supplements; it can increase the medication's effects and lead to potential side effects.
• Limit or avoid cranberry juice as it may interfere with the metabolism of Rosuvastatin, affecting its effectiveness.
• Licorice consumption should be controlled as it might affect the medication's metabolism and increase the risk of side effects.
• Avoid Seville oranges and their juice; they can increase the medication's concentration in the blood, potentially leading to adverse effects.
• Always follow dietary recommendations provided by your healthcare professional for optimal results.

Rosuvastatin 100mg Tablets should be stored in a secure and dry location, preferably at room temperature, between 68°F and 77°F (20°C and 25°C). Protect the tablets from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. It is crucial to dispose of any unused or expired medication responsibly; do not throw it into the trash or flush it down the toilet. Contact your pharmacist or healthcare provider for instructions on proper disposal methods. Ensure that the medication is stored safely, out of the reach of children and pets, to prevent accidental consumption.

Following are the quick tips for Rosuvastatin 100mg Tablet:

• Always take the medication as directed by your doctor, typically once daily.
• Choose a consistent time each day to take the tablet for better effectiveness.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• It can be taken with or without food, but maintaining a routine is advisable.
• Avoid consuming grapefruit or grapefruit juice while on this medication.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.