RYZODEG FLEX PEN 3ML (5'S)

Insulin aspart is a rapid-acting insulin analog that mimics the action of the body's natural insulin. It has a faster onset of action compared to regular human insulin. Insulin aspart binds to insulin receptors on cell surfaces, promoting glucose uptake into cells, especially in muscle and adipose tissue. This action lowers blood glucose levels. Insulin degludec, on the other hand, is an ultra-long-acting insulin analog. It forms multihexamer chains under the skin, resulting in a slow and continuous release of insulin. These chains provide a sustained and steady concentration of insulin in the bloodstream, leading to a prolonged duration of action and a stable basal insulin level.

Insulin aspart 0.3, Insulin degludec 0.7

Insulin

injection

The following are the uses of Insulin aspart 0.3, Insulin degludec 0.7 Injection:

• Used for effectively managing type 1 and type 2 diabetes by controlling blood sugar levels
• Used for providing a fast-acting insulin analogue that helps in quick absorption and rapid onset of action
• Used for offering a long-acting insulin analogue, ensuring a steady and prolonged glucose control
• Used for improving glycemic control, especially in cases where a stable basal insulin level is required
• Used for reducing the risk of hypoglycemic episodes, allowing for more flexibility in meal timings
• Used for enhancing insulin sensitivity, making it easier to manage blood glucose fluctuations
• Used for providing a convenient and discreet way of insulin administration, promoting better patient compliance

In the case of an overdose of Insulin aspart 0.3 and Insulin degludec 0.7 Injection, individuals may experience hypoglycemia, characterized by symptoms such as dizziness, sweating, tremors, and confusion. Promptly administering glucose or sugary foods/drinks can help raise blood sugar levels. Medical attention should be sought immediately, as severe cases may require intravenous glucose administration and close monitoring to prevent complications. It is crucial to act swiftly and seek professional help.

In the case of a missed dose of Insulin aspart 0.3, administer it as soon as you remember, but if it's close to the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. For Insulin degludec 0.7 Injection, if a dose is missed, take it as soon as possible and then adjust subsequent doses by evenly spacing them throughout the day, ensuring you complete the full daily dose within a 24-hour period. If unsure, consult your healthcare provider for guidance on managing missed doses.

To administer the Insulin aspart 0.3, Insulin degludec 0.7 Injection, first clean the injection site with an alcohol swab, then insert the needle at a 90-degree angle and inject the prescribed dose subcutaneously, ensuring you press the plunger slowly and hold it for a few seconds before withdrawal.

Following are the conditions or situations when Insulin aspart 0.3, Insulin degludec 0.7 Injection should not be used:

• Should not be used if you are allergic to insulin aspart, insulin degludec, or any other similar types of insulin.
• Not suitable for individuals with hypoglycemia (low blood sugar) or if you are experiencing frequent episodes of low blood sugar.
• Contraindicated during episodes of hypoglycemic coma or diabetic ketoacidosis.
• Should be used with caution and under medical supervision in individuals with kidney or liver disease.
• Not recommended for use during pregnancy or breastfeeding without medical advice.
• Avoid using this medication if you have a history of severe reactions to other insulin medications.
• Discontinue use if you experience severe or persistent skin reactions at the injection site.

The side effects of Insulin aspart 0.3 and Insulin degludec 0.7 Injection may include:

• Hypoglycemia (low blood sugar)
• Injection site reactions (such as redness, swelling, or itching)
• Skin reactions (rash, itching)
• Weight gain
• Dizziness or lightheadedness
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue/throat)
• Swelling of the hands or feet
• Changes in blood fat levels

Following are the precautions and warnings for Insulin aspart 0.3, Insulin degludec 0.7 Injection:

• This medication should not be shared with others, even if they have similar symptoms, as it is crucial to follow the prescribed dosage for each individual.
• Regular monitoring of blood sugar levels is essential, and adjustments to the dosage may be required based on these readings.
• Patients with a history of hypersensitivity or allergies to insulin or any of the excipients in the injection should avoid its use.
• Patients with renal or hepatic impairment may require dosage adjustments, and close monitoring is advised.
• Hypoglycemia (low blood sugar) is a potential risk, and patients should be educated on its symptoms and management.
• When administered with other antidiabetic medications, close monitoring for hypoglycemia and adjustment of dosages may be necessary.
• Patients should be advised to rotate injection sites to minimize the risk of lipodystrophy and skin reactions.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication, as insulin requirements may change during these periods.

Following are the drug interactions for Insulin aspart 0.3, Insulin degludec 0.7 Injection:

• Beta-blockers, ACE inhibitors, and ARBs may mask the symptoms of hypoglycemia, requiring careful monitoring of blood glucose levels.
• Octreotide and lanreotide can affect glucose metabolism and may require insulin dose adjustments.
• Drugs that affect the central nervous system, like alcohol and opioids, can increase the risk of hypoglycemia.
• Corticosteroids, glucagon, and certain medications for asthma (e.g., salbutamol) may increase blood glucose levels, necessitating insulin dose adjustments.
• Certain oral anti-diabetic drugs, such as sulfonylureas and glinides, can increase the risk of hypoglycemia when used with insulin.
• Medications that impact kidney function, including ACE inhibitors and diuretics, may affect insulin clearance and require dosage modifications.
• Drugs that alter liver function, such as rifampicin, can impact insulin metabolism and may necessitate insulin dose adjustments.

Following are the food interactions for Insulin aspart 0.3, Insulin degludec 0.7 Injection:

• Avoid alcohol consumption as it can interfere with blood glucose control and may lead to hypoglycemia or unpredictable blood sugar levels.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect blood glucose levels and potentially interfere with insulin absorption.
• Maintain a consistent carbohydrate intake, as fluctuations in carbohydrate consumption can impact blood sugar control.
• Avoid excessive caffeine intake, as it may affect blood sugar levels and potentially interact with insulin.
• Be cautious with high-sugar foods, as they can cause rapid increases in blood glucose levels.
• Monitor blood glucose levels closely when consuming foods with a high glycemic index, as they can lead to rapid spikes in blood sugar.
• Always follow a balanced diet as recommended by your healthcare provider for optimal diabetes management.
• Certain herbs like garlic, ginseng, and fenugreek may affect blood glucose levels, so consult your doctor before incorporating them into your diet.

Insulin aspart 0.3 and Insulin degludec 0.7 Injection should be stored in a cool, dry place, preferably in a refrigerator between 2°C to 8°C (36°F to 46°F). Protect the vials or pens from direct sunlight and extreme temperatures. Always check the expiration date before use and do not use if the solution appears cloudy or discolored. Proper disposal is crucial; do not throw away or flush insulin; instead, follow local guidelines or consult your healthcare provider for safe disposal methods. Keep the medication out of the reach of children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Insulin aspart 0.3, Insulin degludec 0.7 Injection:

• Roll the insulin pen gently between your hands to ensure proper mixing, but do not shake vigorously.
• Inject the insulin under the skin as directed by your healthcare provider, usually in the upper arm, thigh, or abdomen.
• Rotate injection sites to avoid lipodystrophy or skin changes.
• Do not inject into areas where the skin is thick, lumpy, bruised, or scarred.
• Always use a new needle for each injection to maintain sterility.
• Never share your insulin pen with others to prevent the spread of infections.
• Store the insulin pen as recommended; protect it from extreme temperatures.