Sabril (500mg) 100 Tablets

Vigabatrin's primary mechanism of action is the irreversible inhibition of gamma-aminobutyric acid transaminase (GABA-T), an enzyme responsible for the catabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). By inhibiting GABA-T, vigabatrin increases the concentration of GABA in the brain, which enhances GABA's inhibitory effects on neuronal activity. This is achieved through the irreversible binding of vigabatrin to the pyridoxal-5'-phosphate binding site of GABA-T, leading to the inactivation of the enzyme. As a result, the increased levels of GABA in the synaptic cleft promote inhibitory neurotransmission, reducing neuronal excitability and potentially suppressing seizures.

Anticonvulsant/Antiepileptic

Tablet

The following are the uses of Vigabatrin 500mg Tablet:

• Used for treating complex partial seizures, particularly in patients with uncontrolled secondarily generalized seizures.
• Used for monotherapy or in combination with other anti-epileptic medications.
• Used to control seizures and improve seizure-free periods.
• Used to reduce seizure frequency and severity.
• Used as an adjunctive therapy for refractory epilepsy.
• Used for its ability to increase GABA levels in the brain, which helps stabilize neuronal activity.
• Used to manage seizures associated with Lennox-Gastaut syndrome, a severe form of childhood epilepsy.
• Used under strict medical supervision due to potential side effects and the need for regular monitoring.

In the case of an overdose of Vigabatrin 500mg Tablet, it is important to recognize the potential symptoms, which may include severe drowsiness, confusion, agitation, and in some cases, seizures. Prompt action is necessary; call emergency medical services immediately. Do not induce vomiting as this can worsen the situation. The medical team will provide appropriate treatment, which may involve supportive care and monitoring of vital signs. Timely intervention is crucial to manage the potential risks associated with an overdose of this medication.

In the case of a missed dose of Vigabatrin 500mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is essential to maintain a consistent medication routine for optimal effectiveness.

To take Vigabatrin 500mg Tablet, swallow the tablet whole with a full glass of water, as directed by your healthcare professional, and follow the prescribed dosage instructions, typically taking it at the same time each day to maintain consistent levels of the medication in your body.

Here are the circumstances when Vigabatrin 500mg Tablet should not be taken:

• Must not be taken by individuals who are allergic to Vigabatrin or any of its ingredients.
• Contraindicated in patients with a history of hypersensitivity reactions to the medication.
• Not suitable for patients with severe liver impairment or liver disease.
• Should be avoided in patients with a history of visual field defects or retinal abnormalities.
• Not recommended for individuals with a history of status epilepticus.
• Must be used with caution in patients with a history of mental health disorders, as it may cause psychiatric symptoms.

The side effects of Vigabatrin 500mg Tablet may include:

• Visual disturbances, such as blurred or double vision, visual field defects, or sensitivity to light.
• Headaches or migraines.
• Dizziness or loss of balance.
• Fatigue or drowsiness during the day.
• Insomnia or sleep disturbances.
• Nausea and vomiting.
• Weight gain.
• Anxiety or irritability.

Following are the precautions and warnings for Vigabatrin 500mg Tablet:

• Vigabatrin should only be used under close medical supervision and is typically reserved for patients who have not responded adequately to alternative treatments.
• Regular eye examinations are crucial while taking this medication due to the risk of permanent vision loss. Discontinue use if any visual disturbances occur.
• Patients with a history of psychiatric disorders should exercise caution, as Vigabatrin may exacerbate these conditions.
• It may cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Alcohol consumption should be avoided as it may intensify the medication's side effects.
• Do not abruptly stop taking Vigabatrin without medical advice, as withdrawal seizures may occur.
• Inform your doctor if you have any kidney or liver problems before starting this medication.
• Keep this medication out of the reach of children and pets, and store it in a secure location.

Following are the drug interactions for Vigabatrin 500mg Tablet:

• May increase the effects of other anticonvulsant medications like phenytoin, leading to enhanced seizure control or potential side effects.
• Combining with benzodiazepines can result in increased sedation and respiratory depression.
• Use with other CNS depressants (e.g., opioids, barbiturates) may exacerbate respiratory depression and sedation.
• Can reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• The effectiveness of Vigabatrin may be reduced when taken with carbamazepine, possibly requiring dosage adjustments.
• Alcohol consumption can intensify the sedative effects of Vigabatrin, affecting coordination and judgment.
• May interact with antiepileptic drugs like valproic acid, potentially affecting seizure control and liver function.

Following are the food interactions for Vigabatrin 500mg Tablet:

• Avoid consuming alcohol with Vigabatrin as it may increase the risk of side effects and alter the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially affect the metabolism of Vigabatrin, leading to increased drug levels in the body.
• High-fat meals might delay the absorption of Vigabatrin, resulting in a slight delay in the onset of its effects.
• Caffeine-rich foods and beverages may increase the risk of seizures, so monitor your intake while on Vigabatrin.
• Avoid eating large amounts of tyramine-rich foods like aged cheeses, cured meats, and certain types of beer, as they can potentially interact with Vigabatrin and affect blood pressure.
• Avoid excessive consumption of foods rich in vitamin B6 (pyridoxine) as it may reduce the effectiveness of Vigabatrin.
• It is advisable to maintain a balanced diet and follow any dietary recommendations provided by your healthcare provider.
• Always consult your doctor or pharmacist for specific dietary guidelines when taking Vigabatrin.

Vigabatrin 500mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring it remains out of reach of children and pets. Maintain the tablets in their original packaging or container to protect them from moisture and light, as exposure to these elements can degrade the medication. It is crucial not to store the tablets in the bathroom or near any heat sources, as temperature fluctuations can impact their effectiveness. Always check the expiration date, and if the medication is expired or no longer needed, do not throw it in the trash or flush it down the toilet. Instead, consult your pharmacist or healthcare provider for specific instructions on how to safely dispose of Vigabatrin tablets to minimize environmental impact and prevent unauthorized access.

Following are the quick tips for Vigabatrin 500mg Tablet:

• Consult your doctor before starting this medication and provide a complete medical history.
• Take the tablet as directed by your doctor; do not crush, chew, or break it.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• Do not take this medication with alcohol as it may increase the risk of side effects.
• Inform your doctor about all the medicines you are taking to avoid potential drug interactions.
• Do not stop taking the medication without consulting your healthcare provider.
• Store the tablets at room temperature, away from moisture and light.