Salazopyrin (500mg) 100 Tablets

Salazopyrin (500mg) 100 Tablets

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  • Manufacturer PARKE-DAVIS
  • Generic Name Sulfasalazine

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Sulfasalazine, a sulfa-containing medication, exerts its therapeutic effects through the combined actions of its two metabolites, sulfapyridine and 5-aminosalicylic acid (5-ASA). Once inside the body, sulfasalazine is primarily metabolized in the intestinal mucosa and liver. This metabolism involves the cleavage of sulfasalazine by bacterial azoreductases, releasing free sulfapyridine and 5-ASA. Sulfapyridine is believed to have mild antibacterial and anti-inflammatory properties, while 5-ASA is the active component responsible for most of the drug's anti-inflammatory effects. 5-ASA reduces inflammation in the colon by inhibiting the production of prostaglandins and other inflammatory mediators, thereby alleviating symptoms associated with inflammatory bowel disease.

  • Ingredients

    Sulfasalazine
  • Drug Class

    Sulfa-based Anti-inflammatory

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Sulfasalazine 500mg Tablet:

    • Used for managing symptoms of ulcerative colitis and Crohn's disease, reducing inflammation in the digestive tract.
    • Used for rheumatoid arthritis treatment, targeting joint pain and swelling.
    • Used to alleviate joint stiffness and tenderness associated with arthritis.
    • Used for reducing morning stiffness and improving joint mobility.
    • Used in the long-term management of inflammatory bowel diseases.
    • Used to maintain remission periods and prevent flare-ups.
    • Used as an alternative for patients intolerant to other medications.
  • In case of Overdose

    In the case of an overdose of Sulfasalazine 500mg Tablets, it is important to recognize the potential symptoms and seek medical advice promptly. Common signs of overdose may include nausea, vomiting, and diarrhea. In more severe cases, individuals may experience abdominal pain, dizziness, or even seizures. If an overdose is suspected, contacting a healthcare professional or poison control center is recommended to ensure appropriate medical guidance and treatment.

  • Missed Dose

    In the case of a missed dose of Sulfasalazine 500mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for advice on how to safely adjust your medication schedule and ensure the best course of action for your treatment.

  • How To Use

    To take Sulfasalazine 500mg Tablets, swallow the tablet whole with a full glass of water, preferably with food, at the same time each day, following the dosage instructions provided by your healthcare professional, ensuring you do not exceed the prescribed amount.

  • When Not to Use

    Following are the conditions/situations when Sulfasalazine 500mg Tablet should not be taken:

    • Must not be used in individuals with a known allergy to Sulfasalazine or any of its components, including sulfa drugs or salicylates.
    • Contraindicated in patients with severe kidney or liver disease, as it may worsen these conditions.
    • Should not be used in individuals with a history of severe bone marrow depression or blood disorders.
    • Not suitable for patients with intestinal or urinary obstructions, as it may cause further blockage.
    • Must be avoided in people with porphyria, as it can trigger an attack.
    • Contraindicated in individuals with a known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
    • Should not be used during the last trimester of pregnancy, as it may cause kernicterus in newborns.
    • Not recommended for breastfeeding mothers, as it can pass into breast milk and harm the nursing infant.
    • Avoid in patients with severe diarrhea or dehydration, as it may exacerbate these conditions.
  • Side Effects

    The side effects of Sulfasalazine 500mg Tablet may include:

    • Nausea and vomiting
    • Loss of appetite
    • Stomach pain or cramps
    • Diarrhea
    • Headache
    • Skin rashes or itching
    • Yellowing of the skin or eyes (jaundice)
    • Sensitivity to sunlight
  • Precautions & Warnings

    Following are the precautions and warnings for Sulfasalazine 500mg Tablet:

    • This medication should not be taken by individuals with a known allergy to Sulfasalazine or its components, or those allergic to sulfa drugs or salicylates.
    • Regular blood tests are required to monitor liver and kidney function, as well as blood cell counts, during treatment.
    • Not recommended for individuals with severe kidney or liver disease, as it may worsen these conditions.
    • Caution is advised for patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as Sulfasalazine can cause hemolytic anemia in these individuals.
    • May cause temporary infertility in men; consult your doctor if you are planning to father a child.
    • Avoid alcohol consumption as it may increase the risk of liver problems.
    • Inform your doctor if you have any blood disorders, intestinal or urinary obstructions, or porphyria before taking this medication.
    • Sulfasalazine may cause your urine, sweat, or skin to turn yellowish, which is usually harmless.
  • Drug Interactions

    Following are the drug interactions for Sulfasalazine 500mg Tablet:

    • Sulfasalazine may reduce the effectiveness of antidiabetic medications, requiring careful blood sugar monitoring.
    • It can decrease the absorption of folic acid, so folic acid supplementation is recommended during treatment.
    • Concomitant use with digoxin can increase digoxin levels, requiring close monitoring.
    • May reduce the efficacy of oral contraceptives, so alternative contraception methods should be considered.
    • Sulfasalazine may enhance the anticoagulant effect of warfarin, necessitating regular monitoring of INR.
    • It can decrease the effectiveness of methotrexate, potentially requiring dosage adjustments.
    • Sulfasalazine may increase the risk of toxicity when used with other drugs that are metabolized by the liver, such as azathioprine.
  • Food Interactions

    Following are the food interactions for Sulfasalazine 500mg Tablet:

    • Avoid consuming alcohol while taking this medication as it may increase the risk of liver-related side effects and gastrointestinal issues.
    • Sulfasalazine may decrease folic acid levels in the body, so consuming foods rich in folate like leafy greens, citrus fruits, beans, and fortified cereals is recommended.
    • Taking Sulfasalazine with a meal can reduce the risk of nausea and stomach upset, a common side effect of this drug.
    • Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Sulfasalazine, potentially altering its effectiveness.
    • Dairy products, especially milk, can decrease the absorption of Sulfasalazine. Consider separating milk intake from medication by a few hours.
    • Iron-rich foods like red meat, liver, beans, and iron-fortified cereals may interfere with Sulfasalazine absorption. Avoid taking them together.
    • Vitamin B6 (pyridoxine) levels may decrease with Sulfasalazine use. Include foods rich in B6 like bananas, chicken, and whole grains in your diet.
    • Sulfasalazine may cause changes in appetite, so maintain a balanced diet to ensure adequate nutrition.
  • Storage/Disposal

    Sulfasalazine 500mg Tablets should be stored in a cool and dry place, preferably at room temperature (68°F to 77°F or 20°C to 25°C). Keep the tablets in their original container, tightly sealed, and away from direct exposure to sunlight, moisture, or heat sources like ovens or radiators. It is crucial to check the expiration date before using the medication and to dispose of any expired or unused tablets appropriately. Do not flush the medication down the toilet or pour it into drainage systems. Consult a pharmacist or healthcare professional for guidance on proper disposal methods. Ensure that the tablets are stored out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Sulfasalazine 500mg Tablet:

    • Take the tablet with food to reduce stomach irritation.
    • Swallow the tablet whole; do not crush or chew it.
    • Stay well-hydrated while taking this medication.
    • Avoid taking antacids within 2 hours of this medicine.
    • Complete the full course as prescribed, even if you feel better earlier.
    • Regularly monitor your blood work and liver function while on this medication.
    • Consult your doctor if you develop any skin rashes or persistent nausea.

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