SALMOCAL 100IU INJ

Salcatonin Injection, a synthetic form of the hormone calcitonin, is designed to mimic the body's natural calcitonin. Its primary mechanism of action is to inhibit bone resorption, a process where osteoclasts break down bone tissue, releasing minerals into the bloodstream. Salcatonin binds to specific calcitonin receptors on osteoclasts, leading to a decrease in their activity and bone resorption. This binding triggers a series of intracellular events, including a reduction in calcium release from bone, which helps regulate calcium levels in the blood. By inhibiting osteoclast activity, Salcatonin promotes a shift in bone metabolism towards bone formation, potentially slowing down bone loss and contributing to the management of certain bone-related conditions.

Calcitonin-based drug.

Injection

The following are the uses of Salcatonin Injection:

• Used for treating osteoporosis in postmenopausal women, helping to reduce the risk of fractures.
• Used for managing bone pain and bone metastasis in certain cancer patients, providing relief.
• Used for the treatment of Paget's disease of bone, effectively controlling bone turnover.
• Used for reducing bone loss and maintaining bone density in individuals with osteopenia.
• Used for promoting bone healing and recovery after fractures or orthopedic surgeries.
• Used for managing hypercalcemia, a condition of high calcium levels in the blood.
• Used for its ability to inhibit bone resorption, thereby supporting bone health.
• Used for certain bone-related conditions as prescribed by healthcare professionals.

In the case of an overdose of Salcatonin Injection, it is important to recognize the potential signs and symptoms, which may include severe nausea, vomiting, and abdominal pain. Medical intervention should be sought immediately, as prompt treatment can mitigate the risks associated with an overdose. Depending on the severity, medical professionals may induce vomiting or administer activated charcoal to prevent further absorption. Close monitoring of vital signs and supportive care are crucial during the management of a Salcatonin Injection overdose.

In the case of a missed dose of Salcatonin Injection, it is important to administer the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure you're still receiving the full benefits of the medication. It is crucial to follow the prescribed treatment plan for optimal results.

To administer the Salcatonin Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire medication is delivered before withdrawing the needle.

Here is a list of conditions and situations when Salcatonin Injection should not be used:

• Do not use if you are allergic to salmon calcitonin or any of the excipients in the injection.
• Contraindicated in patients with a history of hypersensitivity or allergic reactions to calcitonin.
• Not recommended for patients with acute or chronic hypocalcemia (low calcium levels in the blood).
• Should not be used in patients with Paget's disease of the bone.
• Avoid using in patients with untreated hyperparathyroidism.
• Not suitable for patients with severe kidney impairment or end-stage renal disease.
• Contraindicated during pregnancy or breastfeeding.
• Do not use in children under 18 years of age as the safety and efficacy have not been established.
• Avoid using if you have a history of multiple allergies or severe allergic reactions.
• Not recommended for patients with a history of medullary carcinoma of the thyroid.

The side effects of Salcatonin Injection may include:

• Nausea and vomiting
• Diarrhea
• Constipation
• Abdominal pain or cramps
• Flushing or redness of the skin
• Headaches
• Dizziness or lightheadedness
• Skin rash or itching.

Following are the precautions and warnings for Salcatonin Injection:

• This medication is intended for intramuscular or subcutaneous use only and should not be administered intravenously.
• Patients with a history of allergies, especially to fish, should inform their doctor, as the injection may contain fish proteins that could trigger an allergic reaction.
• Salcatonin injection may cause flushing, nausea, and a sudden drop in blood pressure; patients should be monitored for these symptoms, especially during the initial stages of treatment.
• It is important to monitor kidney function and calcium levels in the blood during treatment, as the medication can affect these parameters.
• Not recommended for long-term use; prolonged use may lead to decreased effectiveness and potential side effects.
• Patients with a history of gastrointestinal disorders should be cautious as this medication can cause nausea and gastrointestinal discomfort.
• Patients should be advised to maintain a proper diet and take calcium and vitamin D supplements as recommended by their healthcare provider to prevent bone loss.

Following are the drug interactions for Salcatonin Injection:

• Salcatonin may interact with diuretics, particularly thiazide diuretics, leading to increased risk of electrolyte imbalances, especially hypokalemia and hyponatremia.
• It can reduce the effectiveness of beta-blockers and calcium channel blockers, requiring careful monitoring and dose adjustments.
• Anticonvulsants such as phenytoin and carbamazepine may decrease the effects of Salcatonin, necessitating close observation and potential dose modifications.
• Concurrent use with digoxin can increase the risk of digoxin toxicity due to electrolyte disturbances. Regular monitoring of digoxin levels is advised.
• Salcatonin may enhance the anticoagulant effect of warfarin, requiring more frequent monitoring of international normalized ratio (INR) levels.
• NSAIDs (nonsteroidal anti-inflammatory drugs) can reduce the natriuretic and diuretic effects of Salcatonin, potentially leading to fluid retention.
• Combining Salcatonin with other drugs that affect blood pressure, such as ACE inhibitors or angiotensin receptor blockers, may result in excessive blood pressure reduction, requiring dosage adjustments.

Following are the food interactions for Salcatonin Injection:

• Avoid consuming alcohol during treatment with Salcatonin as it may increase the risk of side effects, especially dizziness and drowsiness.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the drug's metabolism, potentially leading to increased levels of Salcatonin in the body.
• Dairy products like milk, cheese, and yogurt can affect the absorption of Salcatonin; it is recommended to maintain a consistent diet before and during the treatment period.
• High-protein meals may influence the absorption and distribution of Salcatonin; consider discussing dietary adjustments with your healthcare provider.
• Avoid caffeine-rich foods and beverages, as they can potentially interact with Salcatonin, affecting its efficacy and increasing side effects.
• Certain herbs and spices, such as St. John's Wort and Ginkgo Biloba, may interfere with Salcatonin's action and should be used with caution.
• Maintain a balanced diet, as nutritional deficiencies can impact the overall effectiveness of the treatment and recovery process.
• Always consult your healthcare provider for personalized advice regarding food interactions and dietary adjustments during Salcatonin therapy.

Salcatonin Injection should be stored in a controlled environment, specifically at room temperature, typically between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from light and do not freeze it, as extreme temperatures can affect its potency. Keep the medication in its original packaging, ensuring it remains sealed and intact to maintain sterility. Once opened, use the injection promptly and do not store any remaining solution for later use. Dispose of all used or expired medication responsibly; do not pour it down the drain or flush it down the toilet. Consult a pharmacist or healthcare professional for guidance on proper disposal methods to minimize environmental impact.

Following are the quick tips for Salcatonin Injection:

• Consult your doctor for the correct dosage and injection procedure.
• Ensure the injection is administered by a trained healthcare professional.
• Follow the prescribed injection schedule for the entire treatment duration.
• Inform your doctor if you have allergies or are using other medications.
• Do not stop the medication without consulting your doctor.
• Report any persistent side effects or unusual symptoms promptly.
• Store the injection as directed on the packaging, away from direct sunlight and moisture.