Saltra (25/125mcg) 120 Doses Inhaler

Fluticasone/Salmeterol combination therapy is commonly used in the management of asthma and chronic obstructive pulmonary disease (COPD). Fluticasone, a synthetic corticosteroid, exhibits its primary mechanism of action by binding to glucocorticoid receptors in the airways. This binding triggers a series of intracellular events, leading to the suppression of multiple inflammatory genes. Fluticasone reduces inflammation by inhibiting the production of pro-inflammatory mediators such as cytokines, chemokines, and adhesion molecules, thereby preventing the recruitment and activation of inflammatory cells. Salmeterol, a long-acting beta-2 adrenergic receptor agonist (LABA), acts by stimulating these receptors in the airways, leading to smooth muscle relaxation. This relaxation results in bronchodilation, which reduces airway resistance and improves airflow, making breathing easier for patients with asthma or COPD. Together, the combination of fluticasone and salmeterol provides both anti-inflammatory and bronchodilatory effects, helping to control symptoms and prevent exacerbations in respiratory conditions.

Fluticasone, Salmeterol

Corticosteroid, Long-acting beta-agonist

Inhaler

The following are the uses of Fluticasone, Salmeterol Inhaler:

• Used for preventing and controlling symptoms of asthma, including wheezing and shortness of breath.
• Used for managing chronic obstructive pulmonary disease (COPD) symptoms, such as coughing and chest tightness.
• Used for reducing inflammation in the airways to improve breathing.
• Used for long-term management of respiratory conditions, providing 24-hour control.
• Used for quick relief of sudden symptoms when used with a rescue inhaler.
• Used for preventing exercise-induced bronchoconstriction.
• Used for decreasing the frequency of asthma attacks and hospitalizations.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Fluticasone Propionate 125mcg is a combination of medicines that go into an inhaler used for the treatment of lung diseases.
• Wide open the airways and facilitate breathing.
• Used according to the disease and severity thereof-
• Preventative Treatment for Asthma-
• Use the combination of drugs in the following scenario- 1 inhalation (1 puff) of Salmeterol 25mcg + Fluticasone Propionate 125mcg twice a day
• 1 inhalation (1 puff) of Salmeterol 25mcg + Fluticasone Propionate 125mcg in the morning and a bronchodilator (e.g. Salbutamol/Levalbuterol) in the evening
• Inhalation Treatment for Asthma Attacks-
• 1 to 2 inhalations (1 to 2 puffs) of Salmeterol 25mcg + Fluticasone Propionate 125mcg every 4 to 6 hours
• 1 inhalation of a short-acting bronchodilator (e.g. Salbutamol/Levalbuterol or Terbutaline) 15 minutes after the inhalations of Salmeterol and Fluticasone Propionate, if necessary

Prevention of Exercise-Induced Asthma-

• 1 inhalation (1 puff) of Salmeterol 25mcg + Fluticasone Propionate 125mcg 15 to 30 minutes before exercise
• Additional inhalations (puffs) of a short-acting bronchodilator (e.g. Salbutamol/Levalbuterol or Terbutaline) may be necessary for 10 to 15 minutes of exercise

In the case of an overdose of Fluticasone and Salmeterol Inhaler, the individual may experience symptoms such as rapid heart rate, tremors, headache, and muscle weakness. Promptly seek medical assistance and inform healthcare professionals about the overdose. They will provide guidance and necessary treatment to manage the symptoms and ensure the patient's well-being. Timely intervention is crucial to prevent potential complications and ensure a full recovery.

In the case of a missed dose of Fluticasone and Salmeterol Inhaler, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication schedule and ensure you're using the inhaler correctly.

To use the Fluticasone, Salmeterol Inhaler, shake the inhaler well, exhale completely, then inhale slowly and deeply through the mouthpiece, holding your breath for a few seconds to ensure the medication reaches your lungs, and repeat as directed by your healthcare provider.

Here are the conditions or situations when Fluticasone and Salmeterol Inhaler should not be used:

• Do not use if you are allergic to any of the ingredients present in the inhaler, including Fluticasone and Salmeterol.
• Avoid using this inhaler if you have a severe allergy to milk proteins as some inhalers may contain lactose.
• Contraindicated in patients with a history of paradoxical bronchospasm (worsening of breathing) with similar medications.
• Not suitable for individuals with untreated or unstable severe heart conditions, such as heart rhythm problems (arrhythmias) or heart disease.
• Should not be used in patients with severe and uncontrolled high blood pressure.
• Avoid using this inhaler if you have a fungal infection in your mouth or throat (oral thrush).
• Not recommended for individuals with a weakened immune system due to conditions like HIV/AIDS or organ transplants.

The side effects of Fluticasone, Salmeterol Inhaler may include:

• Headache
• Throat irritation or pain
• Hoarseness or voice changes
• Dry mouth or throat
• Cough or chest discomfort
• Muscle or bone pain
• Palpitations or increased heart rate
• Tremor or nervousness

Following are the precautions and warnings for Fluticasone, Salmeterol Inhaler:

• This medication is intended for inhalation only and should not be swallowed or injected.
• It is crucial to learn the proper technique for using the inhaler, and regular cleaning is essential to ensure optimal functioning.
• Patients with a history of asthma exacerbations, severe asthma, or those who are prone to asthma-related deaths should be closely monitored while using this medication.
• Individuals with a history of asthma-related hospitalization, emergency room visits, or those requiring systemic corticosteroid therapy should be carefully evaluated before starting this treatment.
• Salmeterol, an ingredient in this inhaler, may increase the risk of asthma-related hospitalization in some patients, especially in children and adolescents.
• Patients should be aware of potential paradoxical bronchospasm and immediately discontinue use if it occurs, seeking alternative treatment.
• Those with heart problems, high blood pressure, diabetes, thyroid problems, osteoporosis, or eye diseases like glaucoma or cataracts should inform their healthcare provider before using this inhaler.
• Fluticasone, another ingredient, may cause systemic side effects, including Cushing's syndrome, adrenal suppression, growth suppression in children, and decreased bone mineral density.

Following are the drug interactions for Fluticasone, Salmeterol Inhaler:

• Beta blockers (e.g., propranolol, metoprolol) may reduce the effects of Salmeterol and should be used with caution.
• Ketoconazole and other strong CYP3A4 inhibitors may increase the exposure of Salmeterol and Fluticasone, potentially leading to increased side effects.
• Fluticasone may interact with other corticosteroids, increasing the risk of systemic corticosteroid effects.
• Salmeterol may interact with other sympathomimetic drugs, causing an additive effect on the cardiovascular system.
• Non-potassium sparing diuretics (e.g., loop diuretics, thiazide diuretics) can increase the risk of hypokalemia when used with Salmeterol.
• Monoamine oxidase inhibitors (MAOIs) may interact with Salmeterol, potentially causing cardiovascular effects.
• Caution is advised when using Fluticasone with other CYP3A4 inhibitors, as it may increase the risk of systemic side effects.

Following are the food interactions for Fluticasone, Salmeterol Inhaler:

• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, potentially leading to increased levels of Salmeterol in the body.
• Avoid consuming large amounts of caffeine-rich foods and beverages like coffee, tea, or energy drinks, as Salmeterol may increase their stimulating effects and cause jitters, anxiety, or elevated blood pressure.
• Avoid high-fat meals as they can potentially slow down the absorption of Fluticasone, reducing its effectiveness.
• Dairy products like milk, cheese, or yogurt should be consumed with care as they may cause a slight decrease in the absorption of Fluticasone.
• Consuming alcohol may lead to increased side effects, especially respiratory issues, so it's best to avoid or limit alcohol intake.
• Avoid eating large meals immediately before or after using the inhaler, as this can affect the deposition of the medication in the lungs.
• No significant interactions with specific foods are reported for Fluticasone, but maintaining a balanced diet is recommended for overall health.
• Always follow the advice of your healthcare provider regarding dietary considerations while using this medication.

Fluticasone, Salmeterol Inhaler should be stored in a cool, dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, moisture, and heat sources like radiators or stoves. The original packaging should be retained, and the inhaler should be kept tightly sealed to maintain its integrity and prevent contamination. It is crucial to check the expiration date on the package regularly and dispose of the inhaler responsibly when it expires or is no longer needed. Avoid flushing or pouring the contents down the drain; instead, seek guidance from a pharmacist or healthcare professional for safe disposal methods. Additionally, keep the inhaler out of children's reach to prevent accidental inhalation.

Following are the quick tips for Fluticasone, Salmeterol Inhaler:

• Always follow your healthcare provider's instructions for using the inhaler.
• Shake the inhaler well before each use to ensure proper medication delivery.
• Inhale slowly and deeply to ensure the medication reaches your lungs effectively.
• Rinse your mouth with water after each use to prevent oral thrush.
• Keep track of your doses and replace the inhaler when the counter reaches zero.
• Store the inhaler at room temperature, away from direct sunlight and heat.
• Clean the inhaler mouthpiece regularly to maintain hygiene.
• Never share your inhaler with others, as it is prescribed specifically for your condition.

Salmeterol 25mcg and Fluticasone Propionate 125mcg are medications that are given to patients to help treat chronic obstructive pulmonary disease (COPD) and asthma. These medications, however, need careful monitoring by a medical professional to ensure safe and effective use. Though lab tests are not necessary for everyone taking these medications, regular assessments are crucial to implement adequate lung care. Regular pulmonary function tests (PFTs) are sometimes carried out to examine how effective the medication is by measuring breathing capacity and gas exchange within the lungs. Additionally, it is important to often conduct general check-ups on your lungs to guarantee the appropriateness of your treatment. Your doctor may alter your medication dosage based on the results. Blood tests and cholesterol level checks may also be advised, especially if the patient has used inhaled corticosteroids (fluticasone propionate is an example) for a while. This ensures that the medication does not cause any unwanted changes in blood chemistry or increase the risk of developing complications such as osteoporosis or diabetes. Though specific lab tests may not be required for everyone taking Salmeterol and Fluticasone Propionate, close monitoring of lung function and regular check-ups are vital precautions for safe, effective usage of the medications. It should be noted that consulting a doctor or healthcare provider is recommended to determine what specific monitoring routines or lab tests are appropriate for each individual case.