Sandostatin (0.1mg/ml) 1ml, 5 Ampoule Injections

Octreotide, a synthetic somatostatin analog, exerts its effects by mimicking the actions of natural somatostatin. It primarily binds to somatostatin receptors, particularly subtypes 2 and 5, which are found on various cells in the body, including endocrine, exocrine, and neuroendocrine cells. Upon binding to these receptors, octreotide inhibits the secretion of numerous hormones, including growth hormone, insulin, glucagon, and gastrin. This inhibition occurs through the suppression of intracellular cyclic adenosine monophosphate (cAMP) production, ultimately leading to a reduction in the release of these hormones. By targeting these receptors, octreotide effectively regulates hormonal secretion and finds utility in managing various endocrine and gastrointestinal disorders.

Somatostatin analog.

Injection

The following are the uses of Octreotide 1mg injection:

• Used for controlling and managing acromegaly, a hormonal disorder caused by excess growth hormone.
• Used for treating carcinoid syndrome, helping to reduce flushing and diarrhea associated with certain tumors.
• Used for managing diarrhea related to gastrointestinal hormones, especially in VIPomas.
• Used for reducing gastrointestinal bleeding in certain bleeding disorders.
• Used for treating certain types of pancreatic tumors (pancreatic neuroendocrine tumors).
• Used for managing dumping syndrome, a condition after stomach surgery.
• Used for emergency management of bleeding due to liver cirrhosis.

In the case of an overdose of Octreotide 1mg injection, there may be an increased risk of adverse effects, primarily related to the gastrointestinal system. Symptoms could include severe nausea, abdominal pain, and diarrhea. Additionally, an overdose might lead to a significant drop in blood pressure and heart rate, potentially causing dizziness or fainting. It is important to promptly contact a healthcare professional or seek medical advice if an overdose is suspected to ensure appropriate monitoring and management of these potential symptoms.

In the case of a missed dose of Octreotide 1mg injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to safely adjust your medication regimen. It is crucial to follow the prescribed dosage and administration guidelines to ensure the medication's effectiveness.

To administer the Octreotide 1mg injection, clean the injection site with an alcohol swab, insert the needle subcutaneously or intramuscularly as directed by your healthcare provider, inject the medication slowly, and properly dispose of the used needle and syringe after the injection.

Here is a list of conditions and situations when Octreotide 1mg injection should not be used:

• Avoid using Octreotide if you have a known allergy or hypersensitivity to Octreotide or similar medications.
• Do not use this injection if you have an untreated or uncontrolled thyroid or adrenal disorder.
• Not recommended for individuals with severe liver disease or impaired liver function.
• Contraindicated in patients with a history of severe gastrointestinal disease or bowel obstruction.
• Should not be used during pregnancy or breastfeeding without consulting a doctor.
• Avoid using this injection if you have a history of gallstones or gallbladder disease.
• Not suitable for individuals with uncontrolled diabetes.
• Do not use Octreotide if you have a history of heart disease or irregular heart rhythm.
• Contraindicated in patients with a history of pancreatitis.

The side effects of Octreotide 1mg injection may include:

• Abdominal pain or cramps
• Diarrhea or constipation
• Nausea and vomiting
• Fatigue and weakness
• Headache or dizziness
• Injection site reactions (pain, redness, swelling)
• Hyperglycemia (high blood sugar)
• Gallbladder stones

Following are the precautions and warnings for Octreotide 1mg Injection:

• This medication should be used with caution in patients with known hypersensitivity or allergy to Octreotide or related compounds. Strict monitoring is necessary in such cases.
• Octreotide can affect blood sugar levels; patients with diabetes should closely monitor their blood glucose and adjust their medication accordingly.
• It may cause gallbladder complications, especially in patients with pre-existing gallbladder problems. Regular monitoring is essential during long-term treatment.
• Caution is advised in patients with kidney or liver disease, as the medication's metabolism may be altered.
• Octreotide can impact heart function, so patients with cardiovascular issues should be closely monitored.
• This injection is not recommended for use during pregnancy unless clearly necessary. Discuss the potential risks with your doctor.
• Breastfeeding women should consult their healthcare provider before using Octreotide, as it may pass into breast milk.

Following are the drug interactions for Octreotide 1mg injection:

• Octreotide may decrease the absorption of cyclosporine, requiring close monitoring of cyclosporine levels.
• Concomitant use with insulin or oral hypoglycemic agents may require adjustment of antidiabetic therapy due to altered glucose control.
• It can decrease the absorption of terfenadine and midazolam, leading to reduced efficacy of these medications.
• Bromocriptine's effectiveness may be reduced when used with Octreotide.
• Drugs metabolized by CYP450 enzymes, such as warfarin, may have altered metabolism and require dosage adjustments.
• Octreotide can decrease the absorption of griseofulvin, potentially reducing its effectiveness.
• Close monitoring is advised when combined with beta-blockers, as Octreotide may enhance the effects of these medications.

Following are the food interactions for Octreotide 1mg injection:

• Avoid consuming large amounts of alcohol as it may interfere with the absorption of Octreotide and increase the risk of side effects.
• Grapefruit and its juice should be consumed with caution as they can affect the metabolism of Octreotide, leading to increased drug levels in the body.
• Avoid high-fat meals before or after taking the injection as fat can affect the absorption rate of the medication.
• Caffeine intake should be monitored as Octreotide may increase its effects, potentially causing nervousness and rapid heartbeat.
• Limit sugar and carbohydrate-rich foods as Octreotide can impact blood sugar levels.
• Ensure adequate fluid and electrolyte intake to prevent dehydration, especially if diarrhea is a side effect.
• Avoid natural licorice and salt substitutes containing potassium, as Octreotide can affect potassium and fluid balance.
• Consult your doctor if you have a history of liver disease, as Octreotide's metabolism may be altered, requiring dosage adjustments.

Octreotide 1mg injection should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight, heat, and moisture by keeping it in its original packaging until ready for use. Ensure the injection is kept away from children and pets to prevent accidental exposure. Do not freeze the medication as it may affect its potency. When disposing of unused or expired injections, do not throw them into the trash or pour them down the drain. Instead, contact your pharmacist or healthcare provider for instructions on safe disposal methods to minimize environmental impact.

Following are the quick tips for Octreotide 1mg injection:

• Administer the injection as directed by your healthcare professional.
• Ensure the injection is given subcutaneously or intramuscularly as instructed.
• Rotate injection sites to minimize discomfort and tissue irritation.
• Dispose of used needles and syringes safely in designated sharps containers.
• Do not reuse needles or syringes to prevent infections.
• Store the injection as directed on the packaging, usually at room temperature.
• Inform your doctor if you have any allergies or medical conditions before starting this medication.