SANTOGAT 400MG TAB

Gatifloxacin 400mg Tablet, a broad-spectrum antibiotic, exerts its bactericidal effect by selectively inhibiting DNA gyrase and topoisomerase IV, essential enzymes responsible for bacterial DNA replication, transcription, and repair. This inhibition leads to rapid disruption of bacterial DNA synthesis, ultimately resulting in bacterial cell death. The mechanism specifically targets these enzymes, which are crucial for the survival of the bacteria, while minimizing interference with mammalian cellular processes.

Gatifloxacin 400mg

Quinolone antibiotic.

Tablet

The following are the uses of Gatifloxacin 400mg Tablet:

• Used for treating bacterial infections, particularly those affecting the lungs, skin, and urinary tract.
• Used for bacterial pneumonia, providing effective relief.
• Used for skin infections like cellulitis, ensuring a swift recovery.
• Used for urinary tract infections, offering a targeted treatment.
• Used for acute sinusitis, providing quick symptom relief.
• Used for chronic bronchitis, helping manage exacerbations.
• Used for certain eye infections, promoting ocular health.
• Used as an alternative for patients allergic to other antibiotics.

In the case of an overdose of Gatifloxacin 400mg Tablets, the severity of symptoms can vary depending on the amount ingested. Common effects may include dizziness, headache, and gastrointestinal issues. More serious complications could lead to severe nausea, vomiting, and in extreme cases, organ damage or failure. It is crucial to seek medical advice promptly and provide detailed information about the overdose, including the number of tablets consumed, to ensure appropriate treatment and management of potential adverse effects.

In the case of a missed dose of Gatifloxacin 400mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen without compromising its effectiveness. It is advisable to maintain a consistent routine to minimize the chances of missing doses in the future.

To take Gatifloxacin 400mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional, ensuring you complete the full course as prescribed.

Following are the conditions when Gatifloxacin 400mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Gatifloxacin or other quinolone antibiotics.
• Contraindicated in patients with a history of myasthenia gravis as it can worsen muscle weakness.
• Not suitable for individuals with a history of tendon disorders or tendon rupture after taking quinolones.
• Should be avoided in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Contraindicated in patients with prolonged QT intervals or heart rhythm disorders.
• Not recommended for individuals with severe liver disease or impaired liver function.
• Should not be used in children and adolescents under 18 years of age due to potential risks to bone and joint development.
• Should be used with caution in elderly patients, as they may be more susceptible to side effects.

The side effects of Gatifloxacin 400mg Tablet may include:

• Diarrhea
• Nausea and vomiting
• Headache
• Dizziness
• Skin rash or itching
• Sensitivity to sunlight (photosensitivity)
• Confusion, disorientation, or hallucinations (especially in elderly patients)
• Changes in blood sugar levels

Here are the precautions and warnings for Gatifloxacin 400mg Tablet:

• Gatifloxacin should not be used in patients with a known hypersensitivity or allergy to the drug or other quinolone antibiotics.
• Patients with a history of seizures or those with conditions that lower the seizure threshold should use Gatifloxacin with caution, as it may increase the risk of seizures.
• This medication can cause tendonitis or tendon rupture, especially in patients over 60 years old, those taking corticosteroids, and those with kidney, heart, or lung transplants. Report any tendon pain immediately.
• Gatifloxacin may cause central nervous system effects like dizziness, lightheadedness, and headache. Avoid activities requiring mental alertness until you know how this drug affects you.
• Patients with kidney or liver disease may require dosage adjustments. Regular monitoring of kidney and liver function is advised.
• The use of Gatifloxacin in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks, as it may cause harm to the fetus or infant.
• Avoid exposure to sunlight or artificial UV rays as Gatifloxacin can increase skin sensitivity, leading to severe sunburn.
• Elderly patients are more prone to developing tendon problems and central nervous system side effects, so careful monitoring is necessary.

Following are the drug interactions for Gatifloxacin 400mg Tablet:

• Avoid concurrent use with other fluoroquinolones, as it may increase the risk of adverse effects.
• Gatifloxacin can enhance the effects of warfarin and other oral anticoagulants, requiring close monitoring of coagulation parameters.
• Theophylline levels may increase when used with Gatifloxacin, leading to potential toxicity.
• Non-steroidal anti-inflammatory drugs (NSAIDs) might increase the risk of central nervous system stimulation and seizures.
• Probenecid can increase the concentration of Gatifloxacin, potentially leading to increased side effects.
• Sucralfate may reduce the absorption of Gatifloxacin, thus decreasing its effectiveness.
• Gatifloxacin should not be taken with antacids containing magnesium or aluminum, as they can decrease its absorption.

Following are the food interactions for Gatifloxacin 400mg Tablet:

• Avoid consuming dairy products like milk, yogurt, or cheese within 2 hours before or after taking the tablet, as calcium can decrease the absorption of Gatifloxacin.
• Avoid caffeine-containing products like coffee, tea, or energy drinks as they may increase the side effects of the medication, particularly nervousness and tremors.
• Grapefruit and grapefruit juice should be consumed cautiously as they can affect the metabolism of the drug, leading to increased levels of Gatifloxacin in the blood.
• Alcohol should be avoided as it may increase the risk of liver-related side effects and can also enhance the nervous system side effects like dizziness.
• High-fat meals may slightly delay the absorption of Gatifloxacin, but it does not significantly impact the overall effectiveness of the medication.
• Ensure adequate fluid intake, especially water, to maintain hydration during the course of treatment.
• Avoid vitamin or mineral supplements without consulting your healthcare provider, as some may interact with the medication.

Gatifloxacin 400mg Tablets should be stored in a secure and dry location, away from direct exposure to sunlight or moisture. Maintain the medication in its original packaging, ensuring the container is tightly sealed to prevent contamination. It is crucial to avoid storing it in bathrooms or near heat-emitting appliances like heaters or radiators, as extreme temperatures can compromise the drug's integrity. Always verify the expiration date, and if the medication is no longer needed or has expired, do not flush it down the toilet or drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods. Additionally, exercise caution to keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Gatifloxacin 400mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take the tablet on an empty stomach, at least 1 hour before or 2 hours after meals.
• Avoid taking antacids, iron supplements, or multi-vitamins within 4 hours of taking the tablet.
• Complete the full course of medication as prescribed, even if you feel better.
• Store the tablets in a cool, dry place, away from sunlight and moisture.
• If you experience any severe side effects or allergic reactions, seek medical attention immediately.