Savesto (200mg) 14 Tablets

Sacubitril/valsartan is a combination medication with an interesting mechanism of action. Sacubitril is a neprilysin inhibitor, which means it blocks the enzyme neprilysin, responsible for breaking down natriuretic peptides in the body. By inhibiting neprilysin, sacubitril increases the levels of these peptides, leading to vasodilation, reduced sodium reabsorption, and decreased blood pressure. Valsartan, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II, which ultimately results in decreased blood pressure and improved cardiovascular function. Together, these two components work synergistically to enhance the beneficial effects on the cardiovascular system, making this combination therapy effective in treating heart failure and hypertension.

Angiotensin Receptor Blocker

Tablet

The following are the uses of Sacubitril 97mg, Valsartan 103mg Tablet:

• Used for treating heart failure and reducing the risk of hospitalization due to heart issues.
• Used to lower blood pressure and improve heart function by relaxing blood vessels.
• Used to enhance patient's ability to exercise and perform daily activities.
• Used to reduce strain on the heart and improve overall cardiac performance.
• Used to manage chronic conditions and prevent further deterioration of the heart.
• Used as a long-term treatment option to improve quality of life.

To be taken as per doctor's prescription

In the case of an overdose of Sacubitril 97mg and Valsartan 103mg Tablet, the patient may experience symptoms such as low blood pressure, dizziness, and increased potassium levels. It is important to seek medical advice promptly. Overdose effects can vary based on individual factors, and healthcare professionals should be consulted to determine the appropriate course of action, which may include monitoring vital signs and providing supportive care. Timely intervention is key to managing overdose incidents effectively.

In the case of a missed dose of Sacubitril 97mg, Valsartan 103mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice on how to improve your adherence to the prescribed treatment plan.

To take the Sacubitril 97mg, Valsartan 103mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Following are the conditions or situations when Sacubitril 97mg, Valsartan 103mg Tablet should not be taken:

• Should not be used in patients with a known allergy or hypersensitivity to Sacubitril, Valsartan, or any other related angiotensin receptor-neprilysin inhibitor (ARNI) medications.
• Contraindicated in patients with a history of angioedema (swelling under the skin) associated with previous use of ACE inhibitors or ARBs (angiotensin receptor blockers).
• Not recommended for patients with severe renal impairment or those on dialysis.
• Should not be used in patients with severe liver impairment or biliary obstruction.
• Contraindicated during pregnancy as it can cause harm to the fetus.
• Should not be used in patients with untreated heart valve problems or cardiac outflow obstruction.
• Not suitable for patients with a history of hereditary angioedema.
• Should be discontinued and not used in patients who develop significant hyperkalemia (high potassium levels) while on treatment.

The side effects of Sacubitril 97mg, Valsartan 103mg Tablet may include:

• Dizziness or lightheadedness
• Cough
• Fatigue or weakness
• Headache
• Nausea or vomiting
• Diarrhea
• Increased potassium levels in the blood (hyperkalemia)
• Low blood pressure (hypotension)

Following are the precautions and warnings for Sacubitril 97mg, Valsartan 103mg Tablet:

• Do not use if you are allergic to Sacubitril or Valsartan or any other angiotensin receptor-neprilysin inhibitors.
• This medication is not recommended for people with a history of angioedema or hereditary angioedema.
• Exercise caution if you have a kidney disease or impairment, as dosage adjustments may be necessary.
• Inform your doctor if you have a history of liver disease or if you are pregnant, planning to become pregnant, or breastfeeding.
• Valsartan may cause excessive lowering of blood pressure, especially when starting the medication or increasing the dose. Monitor blood pressure regularly.
• Avoid the use of potassium supplements or salt substitutes containing potassium without medical advice, as it may lead to increased potassium levels.
• Discontinue use and seek immediate medical attention if you experience symptoms of angioedema, such as swelling of the face, lips, throat, or tongue.

Following are the drug interactions for Sacubitril 97mg, Valsartan 103mg Tablet:

• Concomitant use with other angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors may increase the risk of hypotension and renal impairment.
• Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the antihypertensive effects of this medication and may increase the risk of renal dysfunction.
• Sacubitril/valsartan may increase the blood levels of lithium, potentially leading to lithium toxicity. Close monitoring is necessary.
• The use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium with this medication may lead to hyperkalemia.
• Drugs that inhibit the neprilysin enzyme, such as certain antidepressants (e.g., SSRIs, TCAs) and opioids, may increase the risk of angioedema.
• Sacubitril/valsartan may increase the concentration of digoxin, requiring close monitoring of digoxin levels.
• Caution is advised when combining with other medications that affect potassium levels, as it may lead to hyperkalemia.
• Concurrent use with other drugs that affect the renin-angiotensin-aldosterone system (RAAS) may require close monitoring due to potential additive effects.

Following are the food interactions for Sacubitril 97mg, Valsartan 103mg Tablet:

• Avoid consuming potassium-rich foods like bananas, oranges, and spinach in excess, as the medication can increase potassium levels in the body.
• Limit the intake of high-sodium foods like processed snacks, canned soups, and salty condiments to maintain the effectiveness of Valsartan in controlling blood pressure.
• Alcohol consumption should be minimized as it can further lower blood pressure and increase the risk of dizziness and fainting.
• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of the medication, leading to increased blood levels and potential side effects.
• Avoid high-fat meals as they can affect the absorption of Valsartan, potentially reducing its effectiveness.
• Maintain a balanced diet and monitor salt intake to support the blood pressure-lowering effects of the medication.
• Consult your healthcare provider for personalized dietary recommendations based on your overall health and medication regimen.

Sacubitril 97mg, Valsartan 103mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. It's crucial to avoid storing them in areas with temperature fluctuations, such as bathrooms or near heat sources, as this can impact their effectiveness. Always check the expiration date before use, and if the medication is expired or no longer needed, proper disposal is essential. Do not dispose of the tablets by flushing or pouring them down the drain; instead, consult your pharmacist for safe disposal options to protect the environment. Lastly, ensure the medication is stored securely, out of the reach of children, to prevent accidental consumption.

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Following are the quick tips for Sacubitril 97mg, Valsartan 103mg Tablet:

• Consult your doctor before starting this medication and provide a complete medical history.
• Take this tablet as directed by your doctor, typically twice a day, at the same time each day.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Maintain a consistent medication schedule for optimal effectiveness.
• Do not stop taking the tablet without consulting your doctor, even if you feel better.
• Store the medication at room temperature, away from moisture and light.
• Regularly monitor your blood pressure and kidney function while on this medication.