Saxagen (5mg) 10 Tablets

Saxagliptin, a 5MG tablet, acts as a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, which is a key enzyme in the body. By inhibiting DPP-4, saxagliptin prevents the breakdown of incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). This inhibition leads to an increase in the levels of these hormones, which have several effects on glucose metabolism. Primarily, it enhances insulin secretion by the pancreas in response to elevated blood glucose levels, a process known as glucose-dependent insulin secretion. Simultaneously, it reduces the release of glucagon, a hormone that stimulates the liver to produce glucose, thereby lowering blood glucose levels. The combined effect of these actions results in improved glycemic control in individuals with type 2 diabetes mellitus.

DPP-4 inhibitor

Tablet

The following are the uses of Saxagliptin 5MG Tablet:

• Used for treating type 2 diabetes by helping the body produce more insulin and use it effectively.
• Used to control blood sugar levels and improve glycemic control.
• Used to enhance insulin release after meals, reducing high blood sugar spikes.
• Used as a long-term management option to maintain stable blood glucose levels.
• Used in combination with other diabetes medications for better control.
• Used to potentially reduce the risk of diabetes-related complications.
• Used to help manage diabetes when diet and exercise alone are not sufficient.

In the case of an overdose of Saxagliptin 5MG Tablet, it is crucial to seek medical assistance promptly. Symptoms may include severe nausea, vomiting, and dizziness. Medical professionals should be informed about the overdose, as they can provide guidance and necessary treatment. Prompt action can help mitigate potential adverse effects, and medical advice should be followed to ensure a safe recovery. It is essential to take immediate action and not delay seeking professional help.

In the case of a missed dose of Saxagliptin 5MG Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. However, do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the medication's effectiveness. It is generally recommended to take the missed dose within 12 hours of the scheduled time.

To take Saxagliptin 5MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your doctor, typically taken once daily with or without food.

Following are the conditions when Saxagliptin 5MG Tablet should not be used:

• Should not be taken by individuals with a known allergy to Saxagliptin or other DPP-4 inhibitors.
• Contraindicated in patients with type 1 diabetes mellitus or diabetic ketoacidosis.
• Not recommended for individuals with severe kidney disease or end-stage renal disease.
• Should not be used if you have a history of pancreatitis (inflammation of the pancreas).
• Not suitable for individuals with a serious infection, trauma, or surgery, as it may need to be temporarily stopped.
• Contraindicated in pregnant or breastfeeding women.
• Should not be given to children and adolescents below 18 years of age.
• Avoid if you have a condition called 'congestive heart failure' or a history of angioedema (swelling of the face, lips, tongue, or throat).

The side effects of Saxagliptin 5MG Tablet may include:

• Joint pain
• Headache
• Upper respiratory tract infection
• Urinary tract infection
• Nausea
• Stomach pain
• Dizziness
• Skin rash

Following are the precautions and warnings for Saxagliptin 5MG Tablet:

• Not recommended for individuals with type 1 diabetes or diabetic ketoacidosis, as it is not effective in these conditions.
• Patients with a history of pancreatitis should exercise caution and inform their doctor before taking this medication.
• Regular monitoring of kidney function is necessary, especially in patients with kidney disease or a history of kidney problems.
• This medication may cause joint pain; if severe, patients should seek medical advice.
• It is advisable to inform your doctor if you have a history of heart failure or any heart-related issues before starting Saxagliptin.
• Patients with a history of angioedema should be cautious, as there is a risk of recurrence with this medication.
• Saxagliptin may cause allergic reactions; seek immediate medical attention if you experience symptoms like rash, itching, or difficulty breathing.
• This medication may affect certain laboratory tests, so inform your doctor about all medications you are taking.

Following are the drug interactions for Saxagliptin 5mg Tablet:

• Saxagliptin may increase the risk of hypoglycemia (low blood sugar) when used in combination with other antidiabetic medications, such as insulin or sulfonylureas (e.g., glimepiride, glipizide). Close monitoring of blood glucose levels is recommended.
• Concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase the levels of Saxagliptin in the blood, potentially increasing the risk of side effects. Dose adjustment may be necessary.
• Saxagliptin may have an additive blood glucose-lowering effect when combined with other oral hypoglycemic agents, and careful monitoring of blood glucose is essential to avoid hypoglycemia.
• When used with other medications that affect renal function (e.g., diuretics, ACE inhibitors, angiotensin II receptor blockers), Saxagliptin may increase the risk of renal impairment. Kidney function should be monitored regularly.
• Co-administration with medications that cause fluid retention (e.g., corticosteroids, thiazolidinediones like pioglitazone) may increase the risk of edema. Monitoring for signs of fluid retention and heart failure is recommended.
• Saxagliptin may interact with immunosuppressive agents (e.g., cyclosporine), increasing the risk of adverse effects due to potential changes in drug metabolism. Close monitoring for side effects is necessary.
• The combination of Saxagliptin with medications that increase the risk of lactic acidosis, such as metformin, may require extra caution in patients with renal impairment or other predisposing conditions.
• Use of Saxagliptin in combination with other GLP-1 receptor agonists (e.g., liraglutide, exenatide) may increase the risk of gastrointestinal side effects and pancreatitis. The combination is generally not recommended.
• Saxagliptin may interact with antihypertensive medications, particularly those that affect the renin-angiotensin-aldosterone system (e.g., ACE inhibitors, ARBs), potentially enhancing their effects and increasing the risk of hypotension.

Following are the food interactions for Saxagliptin 5MG Tablet:

• Alcohol consumption should be limited or avoided as it can increase the risk of pancreatitis, a known side effect of Saxagliptin.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Saxagliptin, leading to increased drug levels in the blood and potentially increasing the risk of side effects.
• Avoid high-fat meals as they may affect the absorption of Saxagliptin, potentially reducing its effectiveness.
• Avoid consuming natural licorice as it may interact with Saxagliptin and affect blood pressure.
• Caffeine intake should be monitored as Saxagliptin may increase its effects, leading to symptoms like nervousness and tremors.
• Stay hydrated and maintain a balanced diet to support overall health while taking this medication.
• No specific food restrictions are associated with Saxagliptin, but a healthy diet is recommended for diabetes management.
• Always consult your healthcare provider for personalized dietary advice while on Saxagliptin treatment.

Saxagliptin 5MG Tablets should be stored in a cool, dry area, preferably at room temperature, ensuring protection from light and moisture. The original container should be used to keep the tablets and should be tightly sealed to maintain their integrity. It is crucial not to expose the medication to extreme temperatures, so avoid placing it near heat sources or in direct sunlight. Proper disposal of Saxagliptin is essential; do not flush or pour it down the drain. Consult a pharmacist or healthcare professional for safe disposal methods. Keep the medication away from children to prevent accidental consumption. Always check the expiration date, and dispose of any expired or unused tablets according to local regulations.

Following are the quick tips for Saxagliptin 5MG Tablet:

• Take the tablet as directed by your doctor, usually once daily.
• Consistency is key; take it at the same time each day.
• Swallow the tablet whole with a full glass of water.
• It can be taken with or without food, but be consistent with your choice.
• Avoid crushing, chewing, or breaking the tablet, as it should be swallowed intact.
• If you have difficulty swallowing, inform your healthcare provider.
• Store the medication in a cool, dry place, away from sunlight and moisture.