Scablin (1%) 50g Cream

Lindane cream, also known as gamma-hexachlorocyclohexane, works by disrupting the nervous system of lice and their eggs (nits). It is a broad-spectrum organochlorine insecticide that acts as a neurotoxin, targeting the gamma-aminobutyric acid (GABA) receptors in the insect's central nervous system. When applied topically, Lindane interferes with the normal functioning of the louse's nerve cells, leading to overstimulation and eventual paralysis. This mechanism effectively kills the lice and prevents them from reproducing. The active ingredient in Lindane cream is absorbed through the skin, allowing it to penetrate the lice's protective exoskeleton and exert its insecticidal effect.

Lindane

Antiparasitic scabicide.

Cream

The following are the uses of Lindane Cream:

• Used for treating scabies, an itchy skin condition caused by tiny mites.
• Used for effectively killing the scabies mites and their eggs.
• Used for reducing the intense itching and inflammation associated with scabies infestations.
• Used for preventing the spread of scabies to close contacts.
• Used for treating lice infestations, particularly head lice and their eggs (nits).
• Used for treating secondary infections that may arise due to excessive scratching.
• Used for providing relief from scabies symptoms within a few days of application.
• Used for ensuring complete eradication of the infestation with proper application and hygiene measures.

In the case of an overdose of Lindane Cream, it is important to recognize the signs and act promptly. Symptoms may include headache, dizziness, nausea, and in severe cases, seizures or loss of consciousness. If an overdose is suspected, immediately contact a healthcare professional or poison control center for guidance. They will provide specific instructions based on the individual's condition and the amount of cream applied, ensuring appropriate medical care is administered.

In the case of a missed dose of Lindane Cream, it is important to apply the cream as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the treatment or provide alternative instructions to ensure the medication's effectiveness.

To apply Lindane Cream, thoroughly wash and dry the affected area, then apply a thin layer of the cream, gently massaging it into the skin, ensuring complete coverage, and leave it on for the recommended time as prescribed by your healthcare provider.

Here are the conditions and situations when Lindane Cream should not be used:

• Avoid using Lindane Cream if you have a known allergy or sensitivity to lindane or any of its components.
• Do not use this cream if you have open wounds, cuts, or broken skin at the affected area.
• Contraindicated for individuals with severe skin conditions like eczema, psoriasis, or severe dermatitis.
• Not suitable for infants, young children, pregnant women, or breastfeeding mothers.
• Avoid using Lindane Cream if you have a history of seizures or epilepsy.
• Should not be used in individuals with weakened immune systems or autoimmune disorders.
• Do not apply on skin areas with infections, as it may worsen the infection.
• Avoid using it on skin that is irritated or inflamed due to other skin treatments.
• Contraindicated in patients with liver or kidney disease, as it may affect the metabolism and elimination of the medication.

The side effects of Lindane Cream may include:

• Skin irritation or rash at the application site
• Itching or burning sensation
• Dry skin
• Redness or swelling
• Skin thinning or discoloration
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Seizures (in rare cases)
• Headache and dizziness

Following are the precautions and warnings for Lindane Cream:

• Do not use if you are allergic to lindane or any of its components; skin testing may be required to determine sensitivity.
• This medication is for external use only and should not be ingested or applied near the eyes, nose, mouth, or open wounds.
• Avoid prolonged use, especially on large areas of the body, as it may increase the risk of side effects and toxicity.
• Infants, young children, the elderly, and individuals with weakened immune systems should use Lindane Cream with caution due to increased sensitivity.
• Lindane can be absorbed through the skin, so it should be used with caution in pregnant and breastfeeding women, and only if the potential benefits outweigh the risks.
• Do not use under occlusive dressings or bandages as this may increase absorption and the risk of side effects.
• Wash hands thoroughly after applying the cream to avoid accidental transfer to other body parts or ingestion.
• Keep out of reach of children and pets.

Following are the drug interactions for Lindane Cream:

• Lindane can interact with medications that affect the central nervous system, such as benzodiazepines and opioids, potentially leading to increased sedation and respiratory depression.
• The use of Lindane with other topical medications, especially those containing alcohol or other solvents, may enhance skin absorption and increase the risk of systemic side effects.
• It may interact with warfarin and other anticoagulants, possibly altering their effectiveness and increasing bleeding risk.
• Caution is advised when using Lindane with anti-seizure medications, as it may lower the seizure threshold.
• Lindane can affect the metabolism of certain drugs processed by the liver, including some antidepressants and antifungal medications.
• Combining Lindane with other drugs that are also CYP3A4 inhibitors or inducers can affect its efficacy and increase the risk of adverse effects.
• Avoid using Lindane with other pediculicides, as it may lead to increased skin irritation and reduced treatment effectiveness.

Following are the food interactions for Lindane Cream:

• Avoid consuming excessive amounts of fatty foods as they can increase the absorption of Lindane, potentially leading to increased side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may inhibit certain enzymes in the liver, affecting the metabolism of Lindane.
• Avoid alcohol consumption while using Lindane Cream, as it can increase skin absorption and enhance the risk of side effects.
• Caffeine-rich beverages like coffee and tea might increase the sensitivity of the skin to Lindane, so moderation is advised.
• Spicy foods may cause skin irritation or exacerbate existing skin conditions when using Lindane Cream.
• Dairy products may interact with Lindane, potentially reducing its effectiveness, so consider limiting their intake during treatment.
• Avoid consuming foods with high levels of vitamin A, as Lindane can increase the body's sensitivity to this vitamin, leading to potential toxicity.
• Always follow your healthcare provider's advice regarding dietary restrictions or recommendations when using Lindane Cream.

Lindane Cream should be stored in a secure and controlled environment, specifically in a cool and dry place, away from direct sunlight, moisture, and heat sources. It is crucial to keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. When disposing of Lindane Cream, it is important to follow proper procedures. Do not flush it down the toilet or pour it into any water bodies. Contact your local waste management authorities or healthcare provider for guidance on safe disposal methods to minimize environmental impact. Always keep the cream out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Lindane Cream:

• Apply a thin layer of cream as directed by your doctor, usually once daily for 7-10 days.
• Wash your hands thoroughly before and after application to avoid unnecessary exposure.
• Use the cream only on affected areas, avoiding healthy skin.
• Do not apply near eyes, nose, mouth, or other sensitive areas.
• Do not cover treated areas with airtight dressings or bandages.
• Discontinue use and seek medical attention if irritation, redness, or itching persists or worsens.
• Store the cream at room temperature, away from moisture and heat.