SECNIDAL SYP 750MG

Secnidazole is a nitroimidazole antimicrobial agent that primarily acts through the production of toxic metabolites within susceptible anaerobic bacteria and protozoa. These toxic metabolites bind to DNA, causing strand breakage and inhibition of DNA synthesis, leading to cell death. The mechanism involves the reduction of the nitro group in the molecule, which generates reactive intermediates that disrupt DNA structure and function. This process specifically targets anaerobic microorganisms, as they possess the necessary enzymatic machinery to facilitate this reduction, resulting in the disruption of microbial DNA replication and transcription.

Antiprotozoal agent

Suspension

The following are the uses of Secnidazole 750MG Syrup/Suspension:

• Used for treating amoebic dysentery, a severe form of diarrhea caused by amoeba parasites.
• Used for eliminating intestinal amoebiasis, an infection in the intestines caused by amoebas.
• Used for managing liver abscesses resulting from amoebic infections.
• Used for the treatment of trichomoniasis, a sexually transmitted infection.
• Used for bacterial vaginosis, restoring healthy vaginal bacteria.
• Used for preventing post-surgery infections, especially in gynecological procedures.
• Used for the treatment of giardiasis, an intestinal infection caused by Giardia parasites.
• Used for eradicating certain parasitic worms, ensuring a healthy digestive system.

In the case of an overdose of Secnidazole 750MG Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, dizziness, and headaches. These symptoms can be more severe and may include seizures, difficulty breathing, and loss of consciousness. Prompt medical attention is necessary to manage these effects, and treatment may involve supportive care and monitoring of vital signs to ensure the patient's well-being and recovery.

In the case of a missed dose of Secnidazole 750MG Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed and ensure the medication's effectiveness.

To take Secnidazole 750MG Syrup/Suspension, shake the bottle well, measure the prescribed dose with a measuring cup or oral syringe, and administer the medication orally, following the dosage instructions provided by your healthcare professional, typically taken as directed by your doctor, either with or without food.

Following are the conditions/situations when Secnidazole 750MG Syrup/Suspension should not be used:

• Not suitable for individuals with a known allergy to Secnidazole or other similar medications.
• Contraindicated in patients with a history of severe kidney disease or impairment.
• Should not be used in patients with a rare genetic blood disorder called porphyria.
• Avoid in patients with a history of seizures or epilepsy.
• Not recommended for children under 2 years of age.
• Contraindicated during the first trimester of pregnancy.
• Avoid if you have a history of blood disorders or low white blood cell count.

The side effects of Secnidazole 750MG Syrup/Suspension may include:

• Nausea and vomiting
• Metallic taste in the mouth
• Dry mouth
• Loss of appetite
• Diarrhea or constipation
• Headache
• Dizziness or vertigo

Following are the precautions and warnings for Secnidazole 750MG Syrup/Suspension:

• Do not consume alcohol while taking this medication, as it may cause severe adverse reactions, including facial flushing, increased heart rate, nausea, and vomiting.
• Not recommended for individuals with a known allergy or sensitivity to Secnidazole or other nitroimidazole derivatives.
• Patients with a history of liver or kidney disease should use with caution and under medical supervision, as Secnidazole is primarily metabolized in the liver and excreted by the kidneys.
• May cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Avoid prolonged exposure to sunlight or UV rays during treatment, as Secnidazole may increase photosensitivity, leading to sunburn or skin rash.
• If symptoms persist or worsen, or if new symptoms appear, consult a healthcare professional immediately.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Secnidazole 750MG Syrup/Suspension:

• Alcohol consumption should be avoided during treatment and for at least 48 hours after the last dose, as it may cause a disulfiram-like reaction with unpleasant effects.
• Concomitant use with warfarin or other anticoagulants may potentiate their effects, requiring close monitoring of coagulation parameters.
• Secnidazole may decrease the efficacy of hormonal contraceptives, so alternative birth control methods are recommended during and for up to 7 days after treatment.
• It can inhibit the metabolism of some antiepileptic drugs, increasing their blood levels and potential side effects.
• Drugs that increase gastric pH may reduce the absorption of Secnidazole, affecting its effectiveness.
• Combining with other CNS depressants may enhance their effects, including opioids and benzodiazepines.
• Secnidazole may interact with 5-fluorouracil, potentially increasing its toxicity.

Following are the food interactions for Secnidazole 750MG Syrup/Suspension:

• Alcohol consumption should be avoided during and at least 2 days after treatment with Secnidazole. Alcohol may cause a disulfiram-like reaction, leading to symptoms like flushing, nausea, and headache.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit CYP3A4 enzyme, potentially affecting Secnidazole metabolism and increasing its levels in the body.
• Dairy products, especially milk, may interfere with the absorption of Secnidazole. It's best to avoid consuming milk or other dairy items within 1-2 hours of taking the medication.
• Fatty meals or high-fat foods may delay the absorption of Secnidazole, potentially reducing its effectiveness. It's advisable to take the medication on an empty stomach or with a light meal.
• Caffeine-rich beverages like coffee and tea might enhance the metabolism of Secnidazole, potentially reducing its effectiveness. Consider limiting caffeine intake during treatment.
• Avoid consuming foods or beverages with high sugar content, as Secnidazole is available in syrup/suspension form, and the added sugar can increase the risk of dental issues.
• Certain acidic foods like citrus fruits or juices might irritate the stomach, especially when taken in combination with Secnidazole, which can cause stomach discomfort.
• Spicy foods should be consumed in moderation as they can sometimes irritate the gastrointestinal tract, potentially exacerbating any side effects associated with Secnidazole.

Secnidazole 750MG Syrup/Suspension should be stored with caution, ensuring it is kept in a cool and dry place, preferably at room temperature, shielded from direct sunlight and moisture. Maintain the medication in its original, tightly sealed container to prevent contamination. Avoid bathroom storage or proximity to heat sources like stoves, as temperature fluctuations can compromise the medicine's integrity. Prior to use, verify the expiration date, and if the syrup is unused or past its prime, exercise proper disposal by consulting a pharmacist or healthcare professional. Do not dispose of it through household plumbing or drainage systems. Lastly, keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Secnidazole 750MG Syrup/Suspension:

• Always follow your doctor's prescription for the dosage and duration of this medication.
• Shake the syrup bottle vigorously before each use to ensure a consistent dose.
• Administer the syrup with a measuring cup or spoon to ensure accurate dosing.
• Consume the syrup immediately after measuring to prevent spillage.
• Avoid consuming alcohol during the treatment period as it may cause adverse reactions.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Dispose of any unused or expired medication properly, and do not share it with others.