Septran (40/200mg) 50ml Suspension

Trimethoprim and sulfamethoxazole work synergistically to inhibit bacterial growth. Trimethoprim primarily blocks the action of dihydrofolate reductase, an enzyme crucial for the production of tetrahydrofolic acid, which is essential for bacterial DNA synthesis. Sulfamethoxazole, on the other hand, inhibits dihydropteroate synthase, another enzyme involved in folic acid metabolism. Together, they disrupt the bacterial synthesis of nucleic acids, preventing the replication of bacteria. This dual inhibition mechanism effectively targets and eliminates a wide range of bacteria, particularly those causing respiratory and urinary tract infections.

Sulfonamide/Folic Acid Antagonist

Suspension

The following are the uses of Trimethoprim, Sulfamethoxazole Syrup/Suspension:

• Used for treating urinary tract infections, effectively targeting common bacterial causes.
• Used for addressing respiratory tract infections, providing relief from bacterial-induced symptoms.
• Used for managing ear infections, offering a solution for both acute and chronic cases.
• Used for gastrointestinal infections, helping to eliminate bacterial pathogens.
• Used for skin and soft tissue infections, promoting healing and reducing bacterial colonization.
• Used as a preventive measure for travelers, offering protection against potential bacterial infections.
• Used for community-acquired pneumonia, addressing bacterial causes and supporting recovery.

In the case of an overdose of Trimethoprim and Sulfamethoxazole Syrup/Suspension, symptoms may include nausea, vomiting, diarrhea, and skin rashes. More severe cases can lead to respiratory distress, kidney problems, and liver damage. Prompt medical attention is required, and individuals should seek emergency care if they suspect an overdose. Treatment may involve supportive care and managing symptoms to prevent further complications. It is crucial to act quickly and seek professional help.

In the case of a missed dose of Trimethoprim, Sulfamethoxazole Syrup/Suspension, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice on how to improve adherence.

To administer Trimethoprim, Sulfamethoxazole Syrup/Suspension, shake the bottle well, measure the prescribed dose with the provided measuring device, and give it to the patient by mouth, following the dosage instructions from your healthcare provider, with or without food, ensuring the entire dose is taken.

Following are the conditions when Trimethoprim, Sulfamethoxazole Syrup/Suspension should not be used:

• Should not be used in patients with a known allergy to Trimethoprim, Sulfamethoxazole, or other sulfonamides.
• Contraindicated in infants less than 2 months of age due to the risk of hyperbilirubinemia.
• Not recommended for individuals with severe liver or kidney disease.
• Should not be used in patients with a history of blood disorders, such as folate deficiency, megaloblastic anemia, or severe thrombocytopenia.
• Contraindicated during the last trimester of pregnancy due to the potential risk of jaundice in newborns.
• Should be avoided in individuals with a known deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD).
• Not suitable for patients with severe dehydration or those unable to maintain adequate fluid intake.
• Should not be used in patients with a history of severe skin reactions to other medications.
• Contraindicated in patients with a history of severe or life-threatening allergic reactions to other sulfonamides.

The side effects of Trimethoprim, Sulfamethoxazole Syrup/Suspension may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Skin rashes or itching
• Fatigue or weakness
• Joint pain
• Dizziness or lightheadedness
• Insomnia

Following are the precautions and warnings for Trimethoprim, Sulfamethoxazole Syrup/Suspension:

• Not recommended for individuals with known allergies to trimethoprim, sulfamethoxazole, or any of the components in the suspension.
• Patients with kidney or liver problems should use with caution, as dosage adjustments may be necessary.
• Elderly patients may be more susceptible to side effects, and close monitoring is advised.
• Avoid prolonged exposure to sunlight or UV rays, as this medication can increase sensitivity to light.
• Patients should stay well-hydrated while taking this medication to reduce the risk of certain side effects.
• Do not use in infants younger than 2 months old due to the risk of serious side effects.
• Inform your healthcare provider if you have any blood disorders or folate deficiency before taking this medication.
• This medication may interfere with certain laboratory tests, so inform your doctor if you are scheduled for any tests.

Following are the drug interactions for Trimethoprim, Sulfamethoxazole Syrup/Suspension:

• Concurrent use with dofetilide, a cardiac medication, is contraindicated due to the risk of life-threatening arrhythmias.
• May reduce the effectiveness of hormonal contraceptives, requiring additional contraceptive measures.
• Interactions with antidiabetic medications, including sulfonylureas and insulin, can lead to altered blood sugar control.
• Trimethoprim can increase the concentration of methotrexate, a chemotherapy drug, potentially increasing its toxicity.
• The effects of anticoagulants like warfarin may be enhanced, requiring close monitoring of coagulation parameters.
• May reduce the efficacy of live attenuated vaccines, such as measles or varicella vaccines, given concurrently.
• Trimethoprim, Sulfamethoxazole can increase the risk of side effects when used with other drugs metabolized by the liver, including certain anticonvulsants and immunosuppressants.

Following are the food interactions for Trimethoprim, Sulfamethoxazole Syrup/Suspension:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and liver-related issues.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of the drug, potentially increasing the levels of Sulfamethoxazole in the body, leading to a higher risk of side effects.
• Dairy products like milk, cheese, and yogurt may interfere with the absorption of Trimethoprim and Sulfamethoxazole, reducing their effectiveness. Consider taking the medication at least 2 hours before or after consuming dairy.
• Foods high in vitamin K, such as leafy green vegetables (spinach, kale), broccoli, and Brussels sprouts, may reduce the effectiveness of blood-clotting medications when taken with Trimethoprim and Sulfamethoxazole.
• Avoid high-sodium foods as Trimethoprim and Sulfamethoxazole can lead to increased sodium levels in the body, especially in individuals with impaired kidney function.
• Avoid or limit caffeine intake as it can increase the risk of side effects like nervousness, tremors, and rapid heartbeat when combined with this medication.
• Consuming high-fat meals may slightly delay the absorption of Trimethoprim and Sulfamethoxazole, but it is generally not considered a significant interaction.
• Always stay well-hydrated while taking this medication to reduce the risk of certain side effects.

Trimethoprim, Sulfamethoxazole Syrup/Suspension should be stored in a secure and controlled environment, preferably in a designated medication storage area. Keep the syrup/suspension at room temperature, avoiding exposure to direct sunlight, excessive heat, or freezing conditions as these can degrade the medication. Ensure the container is tightly sealed to maintain its integrity and prevent contamination. Always check the expiration date before administering the medication, and discard any expired or unused portions responsibly. When disposing of the medication, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for guidance. Keep the medication locked and out of children's reach to prevent accidental ingestion.

Following are the quick tips for Trimethoprim, Sulfamethoxazole Syrup/Suspension:

• Ensure you follow the prescription instructions provided by your doctor for effective treatment.
• Administer the correct dose as prescribed; do not alter the dosage without medical advice.
• Always measure the syrup with the provided measuring cup or syringe for accuracy.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Do not use the medication if it has expired; check the expiration date regularly.
• Contact your doctor if you experience any unusual symptoms or side effects.
• Keep a record of your medication intake to track progress and share with your healthcare provider.