Silage (50mg) 20 Tablets

Levosulpiride's primary mechanism of action is as a selective antagonist of dopamine D2 and D3 receptors, primarily in the gastrointestinal tract and central nervous system. It preferentially binds to presynaptic autoreceptors, leading to a decrease in dopamine release. In the gastrointestinal tract, this action reduces dopamine-mediated inhibition of gastric motility and increases gastric, biliary, and pancreatic secretions, enhancing gastrointestinal motility and digestive processes. In the central nervous system, levosulpiride's action on dopamine receptors may contribute to its effects on nausea and vomiting by influencing the chemoreceptor trigger zone. Additionally, it may have indirect effects on other neurotransmitter systems, such as serotonin and acetylcholine, which could further contribute to its therapeutic actions.

Levosulpiride 50mg

Antipsychotic/Prokinetic

Tablet

The following are the uses of Levosulpiride 50mg Tablet:

• Used for treating digestive problems like dyspepsia, gastroesophageal reflux disease (GERD), and functional indigestion.
• Used to manage symptoms of nausea and vomiting, especially in post-operative or chemotherapy patients.
• Used for effective relief from heartburn and upper abdominal pain.
• Used to stimulate gastric motility and improve digestion.
• Used in the treatment of functional gastrointestinal disorders, such as irritable bowel syndrome (IBS).
• Used to reduce symptoms of bloating, fullness, and early satiety.
• Used for short-term management of anxiety-related gastrointestinal symptoms.

In the case of an overdose of Levosulpiride 50mg Tablets, symptoms may include severe drowsiness, tremors, and abnormal muscle movements. If an overdose is suspected, seek medical advice promptly. It is important to monitor for any signs of overdose, especially in individuals with pre-existing health conditions. Common side effects may be exacerbated, and medical intervention might be necessary to manage the symptoms effectively.

In the case of a missed dose of Levosulpiride 50mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to adjust your dosing schedule and ensure the medication's effectiveness.

To take Levosulpiride 50mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically taken 15-30 minutes before meals, or as directed by your doctor.

Following are the conditions/situations when Levosulpiride 50mg Tablet should not be taken:

• Avoid if allergic to Levosulpiride or any similar medications.
• Do not use in patients with known gastrointestinal bleeding or obstruction.
• Contraindicated in patients with phaeochromocytoma (a rare tumor of the adrenal gland).
• Not suitable for individuals with severe kidney or liver impairment.
• Should not be administered to patients with suspected or confirmed breast cancer.
• Avoid if there is a history of epilepsy or seizures.
• Not recommended for individuals with prolactin-dependent tumors (e.g., certain types of breast tumors).
• Do not administer to patients with porphyria (a group of disorders that affect the skin or nervous system).
• Contraindicated in patients with suspected or diagnosed intestinal perforation.

The side effects of Levosulpiride 50mg Tablet may include:

• Restlessness and involuntary movements
• Weight gain
• Skin rashes or allergic reactions
• Dizziness and lightheadedness
• Sleepiness or insomnia
• Gastrointestinal issues like nausea, vomiting, or constipation
• Dry mouth
• Irregular menstrual cycles

Following are the precautions and warnings for Levosulpiride 50mg Tablet:

• This medication should be used with caution in patients with liver or kidney disease, as it may require dose adjustments or close monitoring.
• Levosulpiride may cause extrapyramidal symptoms (EPS), especially in children and adolescents. Regular monitoring for EPS is essential, and the medication should be discontinued if these symptoms occur.
• Elderly patients may be more sensitive to the effects of this drug, so dosage adjustments might be necessary.
• It may cause neuroleptic malignant syndrome (NMS), a potentially life-threatening condition. Discontinue use and seek immediate medical attention if symptoms such as high fever, muscle rigidity, altered mental status, or irregular heart rate appear.
• Patients with a history of seizures or epilepsy should use this medication with caution as it may lower the seizure threshold.
• Levosulpiride may cause QT prolongation, which can lead to serious heart rhythm problems. ECG monitoring is recommended, especially in patients with cardiovascular disease or those taking other medications that prolong the QT interval.
• Not recommended for use in pregnant and breastfeeding women unless the potential benefits outweigh the risks. Consult a healthcare professional for advice.
• This medication may cause drowsiness and dizziness. Patients should avoid driving or operating heavy machinery until they know how the medication affects them.

Following are the drug interactions for Levosulpiride 50mg Tablet:

• Concomitant use with alcohol may cause increased sedation and impaired motor skills.
• May interact with CNS depressants like opioids, benzodiazepines, and barbiturates, enhancing their effects.
• Levosulpiride can increase the risk of cardiac arrhythmias when taken with antiarrhythmic drugs like quinidine and amiodarone.
• Antipsychotic medications may have additive effects when combined, increasing the risk of extrapyramidal symptoms.
• Levosulpiride can reduce the absorption of antacids and some antibiotics, so they should be taken separately.
• May reduce the effectiveness of anticonvulsants such as phenytoin and carbamazepine.
• Caution with anticoagulants like warfarin, as Levosulpiride may alter its metabolism and effect.

Following are the food interactions for Levosulpiride 50mg Tablet:

• Alcohol consumption should be avoided as it may enhance the sedative effects of Levosulpiride, increasing the risk of dizziness and drowsiness.
• Grapefruit and grapefruit juice are to be avoided as they can inhibit the enzyme CYP2D6, leading to increased levels of Levosulpiride in the body, and potentially causing more side effects.
• Fatty foods might slow down the absorption of Levosulpiride, affecting its effectiveness, so it's best to take it on an empty stomach.
• Caffeine intake should be monitored as Levosulpiride may increase its levels, potentially causing anxiety and sleep disturbances.
• Avoid high-sodium foods as Levosulpiride can cause sodium retention, and excessive sodium intake may lead to fluid retention and increased blood pressure.
• Foods rich in protein, especially those high in L-Tryptophan, may interact with Levosulpiride, potentially affecting serotonin levels and causing serotonin syndrome.
• Avoid consuming large amounts of foods containing tyramine, such as aged cheeses, cured meats, and certain types of beer, as Levosulpiride may interact with tyramine, leading to a spike in blood pressure.
• Always ensure you stay well-hydrated when taking Levosulpiride to maintain proper kidney function and prevent dehydration.

Levosulpiride 50mg Tablets should be stored in a cool, dry area, ideally at room temperature, to maintain their integrity. Keep the tablets in their original packaging, ensuring the container is tightly sealed to prevent exposure to moisture or air. It's crucial not to store them in places like bathrooms or kitchens, where humidity and temperature fluctuations can compromise their quality. Always adhere to the expiration date on the packaging, and never use the medication beyond this date. When disposing of unused or expired tablets, avoid flushing them or pouring them down the drain. Instead, consult your pharmacist or local healthcare facility for safe disposal guidelines. Remember, keep all medications, including Levosulpiride, out of children's reach to prevent accidental consumption.

Following are the quick tips for Levosulpiride 50mg Tablet:

• Take the tablet as directed by your doctor, usually 1-2 tablets daily.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Levosulpiride can be taken with or without food, but taking it with food may reduce stomach upset.
• Maintain a consistent daily routine for better effectiveness.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor about all medications you are currently taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.