Sinedopa (275mg) 100 Tablets

Carbidopa and Levodopa are the two components in the Carbidopa-Levodopa combination tablet. Levodopa is a precursor to dopamine, a neurotransmitter in the brain. It is converted into dopamine by an enzyme called dopa decarboxylase. However, when levodopa is administered alone, it can be broken down to dopamine in the periphery, leading to side effects and reduced availability in the brain. This is where carbidopa comes into play. Carbidopa inhibits the peripheral dopa decarboxylase enzyme, preventing the conversion of levodopa to dopamine outside the brain. This inhibition increases the amount of levodopa available to reach the brain, where it can be converted to dopamine, which is essential for treating Parkinson's disease. By inhibiting peripheral dopamine production, carbidopa enhances the effectiveness of levodopa in the central nervous system, leading to improved motor symptoms in patients with Parkinson's disease.

Carbidopa, Levodopa

Dopamine precursor/Decarboxylase inhibitor.

Tablet

The following are the uses of Carbidopa, Levodopa Tablet:

• Used for treating Parkinson's disease and Parkinson-like symptoms, helping to improve muscle control and reduce stiffness.
• Used for restoring the balance of dopamine in the brain, alleviating motor symptoms like tremors and rigidity.
• Used for enhancing the effectiveness of Levodopa, allowing for lower doses and reducing side effects.
• Used for managing medication timing to ensure consistent dopamine levels throughout the day.
• Used for improving overall mobility, allowing patients to perform daily activities with reduced difficulty.
• Used for reducing "wearing-off" periods, where symptoms return before the next dose is due.
• Used for providing a stable and effective treatment option as part of a comprehensive Parkinson's disease management plan.

In the case of an overdose of Carbidopa and Levodopa tablets, symptoms may include severe muscle twitching, agitation, confusion, reduced consciousness, and irregular heart rhythms. Immediate medical attention is necessary, and treatment may involve gastric lavage, activated charcoal, and supportive care. Prompt intervention can help manage symptoms and prevent further complications, emphasizing the importance of seeking medical help without delay.

In the case of a missed dose of Carbidopa, Levodopa Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication routine.

To take the Carbidopa, Levodopa Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, 30 minutes before meals, or as directed by your healthcare professional, ensuring adherence to the prescribed dosage and schedule.

Following are the conditions/situations when Carbidopa, Levodopa Tablet should not be used:

• Avoid if you have known allergies to any of the components in the medication.
• Do not take if you have a history of narrow-angle glaucoma.
• Not suitable for individuals with pheochromocytoma, a tumor of the adrenal gland.
• Should not be used in patients with severe liver or kidney disease.
• Contraindicated for individuals with undiagnosed skin lesions or melanomas.
• Avoid if you have a history of seizures or epilepsy.
• Not recommended for individuals with respiratory, cardiovascular, or kidney problems.
• Do not use if you have severe psychotic disorders or a history of drug-induced psychosis.
• Should not be taken by patients with a history of gastrointestinal bleeding or ulcers.
• Contraindicated during pregnancy or breastfeeding, unless the potential benefits outweigh the risks.

The side effects of Carbidopa, Levodopa Tablet may include:

• Nausea and vomiting
• Dizziness and lightheadedness
• Dry mouth
• Loss of appetite
• Diarrhea or constipation
• Sleep disturbances, including vivid dreams or insomnia
• Muscle twitching or involuntary movements
• Confusion or cognitive changes

Following are the precautions and warnings for Carbidopa, Levodopa Tablet:

• Do not start or stop this medication without consulting your doctor, especially if you have a history of liver or kidney disease.
• This medication may cause drowsiness or dizziness; avoid driving or operating heavy machinery until you know how it affects you.
• Patients with a history of gastrointestinal ulcers or bleeding should exercise caution as this medication may increase the risk of gastrointestinal problems.
• Carbidopa/Levodopa may cause orthostatic hypotension, so take care when rising from a sitting or lying position to avoid dizziness or fainting.
• Do not take this medication if you have a known allergy to any of its components.
• Inform your doctor if you have a history of heart disease, as this medication may affect your cardiovascular system.
• Patients with a history of psychiatric disorders should be closely monitored, as this medication may cause or worsen psychiatric symptoms.

Following are the drug interactions for Carbidopa, Levodopa Tablet:

• Iron supplements and antacids containing aluminum, calcium, or magnesium can decrease the absorption of Levodopa, reducing its effectiveness.
• Using Levodopa with other medications that affect dopamine levels, such as dopamine agonists or MAO inhibitors, can lead to an excessive increase in dopamine activity, causing dyskinesia or other movement disorders.
• The effectiveness of Levodopa may be reduced when used with medications like papaverine, phenytoin, or benzodiazepines.
• Taking Levodopa with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) may increase the risk of serotonin syndrome, a potentially life-threatening condition.
• Medications that raise blood pressure, such as certain decongestants or stimulants, can interact with Carbidopa and exacerbate hypertension.
• Carbidopa can inhibit the metabolism of some medications, including amphetamines and tricyclic antidepressants, potentially increasing their side effects.
• The effects of Levodopa may be decreased when combined with high-protein diets or protein-rich supplements.

Following are the food interactions for Carbidopa, Levodopa Tablet:

• Avoid consuming high-protein foods like meat, fish, eggs, and dairy products close to when you take this medication, as protein can interfere with Levodopa absorption. Separate protein-rich meals and this medication by at least 30 minutes.
• Maintain a consistent diet; sudden changes in dietary habits may affect the medication's effectiveness.
• A balanced diet rich in complex carbohydrates and fiber is generally recommended.
• Levodopa absorption can be enhanced by consuming vitamin B6-rich foods like whole grains, legumes, and bananas.
• Avoid consuming large amounts of foods containing tyrosine, such as cheese, eggs, and nuts, as they can compete with Levodopa for absorption.
• Caffeine intake should be limited as it can reduce the effectiveness of Levodopa.
• Avoid alcoholic beverages as they can interfere with the medication's action and increase the risk of side effects.
• Grapefruit and grapefruit juice may interact with this medication, potentially affecting its metabolism, so it's best to avoid them.

Carbidopa, Levodopa Tablets should be stored in a cool and dry place, preferably at room temperature (around 20-25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It's crucial to keep this medication out of the reach of children and pets to prevent accidental ingestion. Do not store the tablets in the bathroom or kitchen, as exposure to heat, moisture, or direct sunlight can degrade the medication. Dispose of any unused or expired tablets responsibly; do not flush them down the toilet or throw them into the trash. Consult your pharmacist or healthcare provider for guidance on proper disposal methods to ensure environmental safety.

Following are the quick tips for Carbidopa, Levodopa Tablet:

• Take the tablet as directed by your doctor, usually 3 to 4 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent schedule for taking the medication.
• Take the tablet on an empty stomach, at least 30 minutes before or 2 hours after meals.
• If you experience nausea, try taking the tablet with food.
• Do not double the dose to make up for a missed one, just continue with the next scheduled dose.
• Store the medication in a cool, dry place, away from direct sunlight.