Sinemet-275 (25/250mg) 100 Tablets

Carbidopa and Levodopa are the two components in the Carbidopa 25mg/Levodopa 250mg Tablet. Carbidopa primarily acts as a dopa decarboxylase inhibitor. It works by blocking the conversion of levodopa to dopamine in the bloodstream, allowing for more levodopa to reach the brain. Levodopa, on the other hand, is a precursor to dopamine, and once it enters the brain, it is converted into dopamine, a neurotransmitter. This increase in dopamine levels helps to replenish the depleted dopamine stores in the brains of patients with Parkinson's disease, improving motor symptoms and overall functionality.

Carbidopa 25mg, Levodopa 250mg

Dopamine precursor/DOPA decarboxylase inhibitor.

Tablet

The following are the uses of Carbidopa 25mg, Levodopa 250mg Tablet:

• Used for treating Parkinson's disease and Parkinson-like symptoms, improving muscle control and reducing stiffness.
• Used to enhance the effects of Levodopa, allowing for lower doses and reducing side effects.
• Used to alleviate muscle rigidity and tremors, improving overall movement and flexibility.
• Used to manage bradykinesia (slow movement), helping patients initiate and perform movements with ease.
• Used to restore dopamine levels in the brain, addressing the underlying cause of Parkinson's symptoms.
• Used to improve overall quality of life for patients by reducing motor impairments.
• Used as a long-term treatment to manage the progression of Parkinson's disease.

In the case of an overdose of Carbidopa 25mg and Levodopa 250mg Tablets, individuals may experience symptoms such as severe nausea, vomiting, rapid heart rate, confusion, and muscle twitching. Prompt medical attention is necessary, and treatment may involve supportive care, gastric lavage, and monitoring of vital signs. It is important to seek emergency medical assistance if an overdose is suspected, as timely intervention can help manage symptoms and prevent potential complications.

In the case of a missed dose of Carbidopa 25mg, Levodopa 250mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen.

To take the Carbidopa 25mg, Levodopa 250mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the circumstances when Carbidopa 25mg, Levodopa 250mg Tablet should not be administered:

• Should not be taken by individuals with a known allergy to Carbidopa, Levodopa, or any other similar medications.
• Contraindicated in patients with narrow-angle glaucoma.
• Not suitable for individuals with severe liver or kidney disease.
• Should not be used in patients with undiagnosed skin lesions or melanoma.
• Contraindicated in patients with a history of seizures or seizure disorders.
• Not recommended for individuals with respiratory, cardiovascular, or renal complications due to the presence of sulfite in the medication.

The side effects of Carbidopa 25mg, Levodopa 250mg Tablet may include:

• Nausea and vomiting
• Dry mouth
• Dizziness or lightheadedness
• Confusion or hallucinations
• Rapid or irregular heartbeat
• Orthostatic hypotension (a sudden drop in blood pressure upon standing)
• Involuntary movements or twitching
• Gastrointestinal bleeding

Following are the precautions and warnings for Carbidopa 25mg, Levodopa 250mg Tablet:

• Not recommended for individuals with known hypersensitivity to Carbidopa, Levodopa, or any other ingredients in the tablet.
• May cause drowsiness and dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Patients with a history of gastrointestinal ulcers should be closely monitored as the medication may worsen these conditions.
• Use with caution in patients with heart, lung, or kidney disease, as it may require dosage adjustments.
• Not recommended for use in children, pregnant or breastfeeding women, and elderly patients without medical advice.
• May cause orthostatic hypotension; patients should rise slowly from a sitting or lying position to prevent dizziness or fainting.
• Patients with a history of psychiatric disorders should be closely monitored as the medication may exacerbate psychiatric symptoms.

Following are the drug interactions for Carbidopa 25mg, Levodopa 250mg Tablet:

• Iron salts, such as those found in multivitamins, can reduce the absorption of Levodopa, decreasing its effectiveness.
• Combining with Tricyclic antidepressants may lead to increased risk of adverse effects, including confusion, hallucinations, and muscle twitching.
• Antipsychotic medications can reduce the effectiveness of Levodopa and worsen Parkinson's symptoms.
• Levodopa may interact with certain anti-nausea medications like Metoclopramide, affecting its absorption.
• The effects of Levodopa can be reduced by drugs that increase urinary pH, such as some carbonic anhydrase inhibitors.
• MAO inhibitors can interact with this medication, potentially leading to severe adverse effects.
• Concomitant use with certain anti-seizure medications like Phenytoin may decrease Levodopa levels.

Following are the food interactions for Carbidopa 25mg, Levodopa 250mg Tablet:

• Avoid high-protein foods and beverages, as they can interfere with Levodopa absorption, reducing its effectiveness.
• Consume a balanced diet with complex carbohydrates and moderate protein intake to ensure a steady supply of Levodopa.
• Maintain a consistent daily protein intake to optimize Levodopa's therapeutic effects.
• Consider taking the medication 30-60 minutes before meals to minimize protein interference.
• Avoid consuming large amounts of foods rich in Vitamin B6, like whole grains, liver, and certain vegetables, as it may reduce Levodopa's effectiveness.
• Limit or avoid alcohol consumption, as it can affect dopamine levels and interact with the medication, causing unpredictable effects.
• Caffeine intake should be monitored, as it can influence the medication's action and potentially cause restlessness and increased heart rate.
• Some foods like aged cheeses, cured meats, and fermented foods contain high levels of Tyramine, which may interact with Levodopa, leading to increased blood pressure.

Carbidopa 25mg, Levodopa 250mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to store the medication in bathrooms or areas exposed to heat, as temperature fluctuations can impact its effectiveness. Regularly check the expiration date, and if the medication is no longer needed or has expired, do not flush it or discard it in drains. Instead, follow appropriate disposal guidelines provided by your pharmacist or healthcare professional to ensure environmental safety. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Carbidopa 25mg, Levodopa 250mg Tablet:

• Ensure you take the tablet as directed by your doctor.
• Maintain a consistent daily routine for taking the medication.
• Swallow the tablet whole with a full glass of water.
• Do not crush, chew, or break the tablet.
• Take the tablet on an empty stomach, at least 30 minutes before a meal.
• Avoid consuming alcohol while taking this medication.
• Inform your doctor about all medications you are currently taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.