Sita-Met XR (100/1000mg)14 Tablets

Sitagliptin works by inhibiting the breakdown of incretins, hormones that regulate blood sugar levels. By keeping these hormones in the bloodstream longer, insulin production is stimulated only when blood sugar levels are elevated, effectively reducing blood sugar levels in patients with type 2 diabetes mellitus. Metformin is a drug that belongs to the biguanide class, and it works by reducing glucose production in the liver and increasing glucose absorption by skeletal muscles. Unlike other drugs for managing type 2 diabetes, Metformin does not increase insulin secretion from the pancreas. This feature helps reduce the excessive workload on the pancreas, which is particularly beneficial for those whose pancreas is producing less insulin or whose bodies are resistant to insulin effects.

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Biguanide, DPP-4 Inhibitor

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Sitagliptin 100mg is used alongside diet and exercise in adults with type 2 diabetes to help lower blood sugar.
• Metformin Hydrochloride 1000mg is also used alongside diet and exercise in adults with type 2 diabetes to help lower blood sugar.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For Sitagliptin 100mg
• Take one tablet with food as a single daily dose.
• Full effect of Sitagliptin may not be seen during the first few weeks of treatment
• Continue using it as directed by your physician
• For Metformin Hydrochloride 1000mg
• Take with a meal to reduce the risk of stomach upset
• Dosage depends on your medical condition, response to treatment, and age
• This medication is to be taken orally, swallowed whole with water or liquid. Do not crush or chew the tablet.

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An overdose of sitagliptin and metformin can lead to various severe symptoms. It is crucial to seek immediate medical attention if you suspect an overdose of these medications. The appropriate treatment varies depending on the individual's symptoms and liver and kidney function, which is why medical attention is essential.The treatment may involve the use of medications such as activated charcoal, to help absorb the drugs and prevent their absorption into the bloodstream. However, in more severe cases, dialysis or a liver flush may be required to remove the drugs from the body. The specific treatment approach will depend on the individual's symptoms, the severity of the overdose, and their medical history. It is important to consult with a medical professional for appropriate treatment guidance.

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It is important to take your medication as soon as possible if you miss a dose, unless it is nearly time for your next scheduled dose. If you miss a dose by only a small amount of time, it is typically best to skip that dose and return to your regular dosing schedule. It is advised that you do not double up on medication doses unless you have consulted with your healthcare provider and they have advised you to do so. For optimal guidance regarding missed doses, it is recommended that you consult with a healthcare professional, who can provide you with personalized advice.

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The combination of sitagliptin and metformin should be taken orally as prescribed by a healthcare provider, typically once or twice daily with meals to reduce gastrointestinal side effects. The dose is based on the patient's current condition, renal function, and prior response to therapy.

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Discerning instances where this medication may not be appropriate:

• Existing Vitamin B12 Deficiency - Since Metformin affects the absorption of Vitamin B12, which can lead to deficiencies, individuals who are B12 deficient should not take Metformin to avoid worsening symptoms.
• Sodium-Containing Products - Metformin is known to cause sodium retention which is unsafe for individuals with certain cardiovascular conditions. Those with heart failure or who have had a recent myocardial infarction should avoid Metformin.

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Unraveling the side effects lurking behind this medications are as follows:

• Nausea, vomiting, stomach pain, diarrhea, and loss of appetite
• Metallic taste in the mouth
• Thirst and frequent urination
• Weakness and dizziness
• Tiredness
• Dry mouth
• Chronic indigestion, or heartburn
• Intestinal yeast infection (such as thrush)
• Skin reactions, such as rash, itching, redness, and swelling
• Gulf War syndrome (tendons and other connective tissues swelling)
• Lactic Acidosis

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Here are the crucial warnings and precautions for this medication:

• Patients with congestive heart failure (CHF) and those exposed to stress, such as infection, fever, trauma, or surgery, should use this medication with caution.
• It is not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus.
• Renal impairment, particularly with a glomerular filtration rate (GFR) between 30-45 mL/min, requires careful monitoring.
• The safety of this medication during pregnancy has not been well established; it should be used only if recommended by a healthcare provider.

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Drug interactions with metformin and sitagliptin include:

• Insulin and other antidiabetic agents (e.g., sulfonylureas) (may increase risk of hypoglycemia)
• Renal impairment (may require dose adjustments)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase sitagliptin levels)
• CYP3A4 inducers (e.g., rifampin) (may decrease sitagliptin levels)
• NSAIDs (e.g., ibuprofen) (may increase risk of renal impairment)
• Alcohol (may enhance effects on blood glucose levels)
• Metformin and sitagliptin generally have minimal interaction with other medications, but individual patient scenarios should always be reviewed for potential interactions.

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Sitagliptin and Metformin Hydrochloride are important medications that should be stored in a safe and dry place at room temperature. Ensure that the medications are kept in an airtight container, away from children and pets. Physicians will provide specific guidelines for storage, and the medication label will provide any additional storage instructions specific to the medication. For any questions regarding the storage of these medications, or any other medications, it is recommended to consult with a medical professional for guidance. It is important to always follow the advice of your trusted medical professional.

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When taking Sitagliptin and Metformin Hydrochloride, it is likely that you will need regular laboratory monitoring to check for any negative side effects and to ensure the medication is working properly. Firstly, blood sugar levels will be monitored to ensure that your body is responding well to the medications, avoiding hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar). Secondly, kidney function tests will be completed regularly to monitor for any kidney damage or decreased kidney function as Metformin is excreted by the kidneys. Thirdly, due to the chance of hyperlipidemia occurring, it is crucial to monitor your cholesterol and triglyceride levels to assess whether there is a need for concurrent lipid-lowering therapy. Lastly, the Hemoglobin A1C test provides an average of your blood sugar levels over the past few months, allowing your doctor to assess how well your body is processing the medication and controlling your diabetes. Your doctor will advise on how often you should be undergoing these tests, ranging from monthly to semi-annually, depending on the outcome of the tests and the stability of your condition. It is important to disclose any adverse effects or changes to your health as this may impact your lab testing schedule and potential medication adjustments.

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