Sitaglu Met Xr (50/1000Mg) 14 Tablets

Metformin 500mg primarily works by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues. It inhibits gluconeogenesis, the process by which the liver produces glucose, and decreases intestinal absorption of glucose. On the other hand, Sitagliptin 100mg, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases insulin secretion in response to meals and decreases glucagon secretion, leading to lower blood glucose levels. This is achieved by inhibiting the breakdown of incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which stimulate insulin release and suppress glucagon release in a glucose-dependent manner.

Oral hypoglycemic combination.

Tablet

The following are the uses of Metformin 500mg, Sitagliptin 100mg Tablet:

• Used for managing type 2 diabetes by lowering blood sugar levels.
• Used to improve insulin sensitivity, allowing better sugar uptake by cells.
• Used to regulate blood sugar spikes after meals due to its glucose-lowering effect.
• Used for long-term blood sugar control when combined with a healthy lifestyle.
• Used to enhance the body's natural ability to regulate blood sugar.
• Used as part of a comprehensive diabetes management plan.
• Used to potentially reduce the risk of diabetes-related complications.

In the case of an overdose of Metformin 500mg and Sitagliptin 100mg tablets, it is important to recognize the potential risks and take appropriate action. Symptoms may include lactic acidosis, hypoglycemia, or gastrointestinal issues. Seek medical advice promptly, as treatment may involve gastric lavage, supportive care, and monitoring of vital signs. Prompt action can help manage the effects of an overdose and ensure the best possible outcome.

In the case of a missed dose of Metformin 500mg, take the missed dose as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. For Sitagliptin 100mg Tablet, if you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and continue with your regular dosing regimen. It's important not to double the dose to compensate for a missed one.

To take Metformin 500mg and Sitagliptin 100mg Tablet, swallow one tablet whole with a full glass of water, preferably during or after a meal, exactly as prescribed by your healthcare provider, typically once or twice a day.

Following are the conditions when Metformin 500mg, Sitagliptin 100mg Tablet should not be used:

• Not suitable for individuals with a known allergy to Metformin, Sitagliptin, or any other similar medications.
• Contraindicated in patients with a history of diabetic ketoacidosis.
• Should not be used in patients with severe kidney disease or kidney failure.
• Not recommended for individuals with severe liver disease or liver impairment.
• Should not be used in patients with a history of pancreatitis.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for individuals with type 1 diabetes.
• Should be avoided if the patient has an upcoming surgery or any medical tests involving injection of contrast dye.

The side effects of Metformin 500mg and Sitagliptin 100mg Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Abdominal pain
• Loss of appetite
• Metallic taste in the mouth
• Headache
• Dizziness or lightheadedness
• Skin rash or itching

Following are the precautions and warnings for Metformin 500mg, Sitagliptin 100mg Tablet:

• This medication is not recommended for individuals with a known allergy to Metformin or Sitagliptin, or any other ingredients in the tablet.
• Patients with kidney problems should exercise caution and consult their doctor, as dose adjustments may be necessary for those with renal impairment.
• Metformin may cause lactic acidosis, a rare but serious condition. Discontinue use and seek medical attention if symptoms such as weakness, fatigue, dizziness, or stomach discomfort occur.
• Patients with a history of liver problems should have regular blood tests to monitor liver function while taking Sitagliptin.
• It is important to maintain a balanced diet and not consume excessive amounts of alcohol while taking this medication.
• This medication may cause hypoglycemia, especially when used with other anti-diabetic medications. Monitor blood sugar levels regularly and recognize the symptoms of low blood sugar.
• Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as the benefits and risks should be carefully considered.

Following are the drug interactions for Metformin 500mg, Sitagliptin 100mg Tablet:

• Concomitant use with insulin or insulin secretagogues (e.g., sulfonylureas) may increase the risk of hypoglycemia, so regular monitoring of blood glucose is advised.
• The diuretic effect of loop diuretics (e.g., furosemide) may be reduced by metformin, potentially affecting fluid balance.
• Sitagliptin may increase the risk of angioedema when used with angiotensin-converting enzyme (ACE) inhibitors.
• Metformin can interact with contrast agents used in imaging procedures, leading to temporary discontinuation of the drug.
• Alcohol intake may increase the risk of lactic acidosis with metformin.
• Certain medications affecting liver function may alter metformin's effectiveness.
• Drugs that increase blood pH (e.g., carbonic anhydrase inhibitors) may impact metformin's renal excretion.

Following are the food interactions for Metformin 500mg, Sitagliptin 100mg Tablet:

• Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, especially in individuals with impaired liver function.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Sitagliptin, potentially altering its effectiveness.
• Avoid high-fat meals as they can decrease the absorption of Sitagliptin, reducing its effectiveness.
• Maintain a balanced diet low in refined sugars and simple carbohydrates to optimize blood sugar control.
• Avoid vitamin B12 deficiency by including vitamin B12-rich foods like meat, fish, and dairy, as Metformin can interfere with its absorption.
• Limit caffeine intake, especially in energy drinks and coffee, as it can impact blood sugar levels and interact with the medication's effects.
• Be cautious with high-sugar foods and beverages, as they can lead to rapid spikes in blood glucose levels, reducing the medication's efficacy.
• Consult a healthcare professional for personalized dietary advice, especially when making significant dietary changes while on this medication.

Metformin 500mg, Sitagliptin 100mg tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep the medication away from children and pets to ensure safety. Disposal of unused or expired tablets should be done responsibly; do not flush or pour them into drainage systems. Consult your pharmacist or local waste management guidelines for appropriate disposal methods to minimize environmental impact. Always handle medications with care and follow the instructions provided by your healthcare professional.

Following are the quick tips for Metformin 500mg and Sitagliptin 100mg Tablet:

• Always take the medication as directed by your doctor, typically with meals.
• Swallow the tablets whole without crushing or chewing for optimal absorption.
• Maintain a consistent medication schedule for better blood sugar control.
• If you miss a dose, take it as soon as you remember, but skip if it's almost time for the next dose.
• Do not double the dose to make up for a missed one.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.