Skilax (7.5mg) 30ml Drops

Sodium picosulfate is a prodrug, meaning it is inactive until it reaches the colon. In the colon, it is metabolized by gut bacteria into its active form, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM). The active metabolite stimulates the nerve endings in the colonic mucosa, which enhances the peristaltic movements of the colon. Peristalsis is the series of wave-like muscle contractions that move stool through the digestive tract. This increased peristaltic activity accelerates the passage of stool through the colon, helping to relieve constipation. Sodium picosulfate also reduces the absorption of water and electrolytes in the colon. This leads to softer stools, making them easier to pass.

Laxative

This medicine is used to:

• Relieve Constipation
• Stimulate Bowel Movements
• Aid in Bowel Evacuation

Sodium Picosulfate dosage recommendations are:

• Constipation - 5-10 mg once daily, may increase to 20 mg daily if needed
• Pre-operative bowel cleansing - 10-20 mg in the evening before the procedure, may be followed by additional doses as instructed by the healthcare provider.

In case of overdose, seek immediate medical attention. Overdose may cause severe diarrhea or dehydration. Follow medical advice and monitor for adverse effects.

If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose. Do not double up.

Shake well before use. Measure the dose using the provided dropper.

Sodium picosulfate should not be used in the following situations:

• Severe renal impairment (creatinine clearance less than 30 mL/minute)
• Gastrointestinal obstruction or ileus
• Bowel perforation
• Toxic colitis or toxic megacolon
• Gastric retention
• Hypersensitivity to any of the ingredients

Potential side effects associated with Sodium Picosulphate include:

• Drowsiness
• Dry mouth
• Dizziness
• Allergic reactions

Patients should be aware of these precautions and warnings when using sodium picosulfate:

• Use with caution in patients with gastrointestinal disorders, such as inflammatory bowel disease, as it may exacerbate these conditions.
• Follow the recommended dosage to avoid potential side effects, including abdominal cramping, diarrhea, or dehydration.
• Prolonged use or overuse can lead to dependence or electrolyte imbalances.
• Patients with renal or hepatic impairment should use this medication under medical supervision, as its effects may be altered.
• It should not be used in children under a certain age without a doctor's advice.
• Consult a healthcare provider before using sodium picosulfate if you are pregnant, breastfeeding, or taking other medications to prevent potential interactions.
• If any severe adverse reactions, such as persistent abdominal pain or signs of dehydration, occur, discontinue use and seek medical advice promptly.

Drug interactions with sodium picosulphate include:

• Other laxatives (e.g., senna) (may have additive effects)
• Antidiarrheals (e.g., loperamide) (may counteract the effects of sodium picosulphate)
• Oral medications (e.g., digoxin, anticoagulants) (may decrease absorption)
• Diuretics (e.g., furosemide) (may increase risk of dehydration and electrolyte imbalance)

Store in a cool, dry place away from heat. Dispose of expired or unused medication at a pharmacy take-back program or follow local disposal guidelines.