Sofiget (400mg) 28 Tablets

Sofosbuvir's primary mechanism of action is based on its ability to inhibit the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. This enzyme is crucial for the replication of the HCV genome. Sofosbuvir is a nucleotide analog inhibitor, meaning it resembles the natural building blocks used by the virus to replicate its genetic material. When Sofosbuvir is incorporated into the growing HCV RNA chain by the NS5B polymerase, it acts as a chain terminator, preventing further elongation of the viral RNA. This effectively halts the replication process, as the virus can no longer produce new copies of its genome, thus suppressing viral replication and reducing the viral load in patients with chronic hepatitis C.

Nucleotide NS5B inhibitor.

Tablet

The following are the uses of Sofosbuvir 400mg Tablet:

• Used for treating chronic Hepatitis C infection.
• Used for improving liver health and reducing viral load.
• Used in combination with other medications for effective viral suppression.
• Used to prevent Hepatitis C-related liver damage and complications.
• Used to achieve sustained virologic response, indicating a successful cure.
• Used for long-term management and control of the virus.

In the case of an overdose of Sofosbuvir 400mg Tablet, it is important to recognize the signs and act promptly. Overdose symptoms may include fatigue, headache, and gastrointestinal issues. If you suspect an overdose, contact a healthcare professional immediately. They will provide guidance and determine the appropriate treatment, which may involve supportive care and monitoring. Quick action can help prevent potential complications and ensure the best outcome.

In the case of a missed dose of Sofosbuvir 400mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set a daily reminder or keep the medication in a visible place to help you remember to take it at the same time each day. If you frequently miss doses, inform your healthcare provider, as they may provide guidance on how to manage your medication schedule effectively.

To take Sofosbuvir 400mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically taken once daily with or without food.

Following are the conditions when Sofosbuvir 400mg Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Sofosbuvir or any of its excipients.
• Not recommended for patients with severe kidney impairment or those on dialysis.
• Contraindicated in patients with decompensated cirrhosis.
• Should be used with caution and under medical supervision in patients with HIV co-infection.
• Not suitable for individuals with a history of liver transplant.
• Avoid using in patients with a history of Hepatitis B or C treatment failure or resistance.
• Do not administer to patients currently taking certain medications, such as amiodarone or rifampicin, due to potential drug interactions.

The side effects of Sofosbuvir 400mg Tablet may include:

• Fatigue
• Headache
• Nausea
• Insomnia
• Diarrhea
• Irritability
• Skin rash
• Anemia

Following are the precautions and warnings for Sofosbuvir 400mg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Sofosbuvir or any of its excipients.
• Patients with a history of liver disease or hepatitis B/C co-infection should be closely monitored for liver function.
• Regular monitoring of liver function tests is necessary during treatment.
• Sofosbuvir may cause fatigue and dizziness; patients should be cautious when driving or operating heavy machinery.
• Elderly patients may require dose adjustments, and close monitoring is advised.
• Patients with kidney impairment should consult a healthcare professional before use, as dosage adjustments might be needed.
• This medication is not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Sofosbuvir 400mg Tablet:

• Rifampin and St. John's Wort can reduce the effectiveness of Sofosbuvir, leading to potential treatment failure.
• Combining with amiodarone may increase the risk of a serious slowing of the heart rate. Close monitoring is required.
• Sofosbuvir may increase blood concentrations of certain antiretroviral drugs like atazanavir and lopinavir/ritonavir, requiring dosage adjustments.
• It can decrease the effectiveness of hormonal contraceptives, so alternative methods of contraception are recommended.
• Telaprevir and boceprevir, used for hepatitis C treatment, should not be taken with Sofosbuvir due to potential drug interactions.
• Use with other direct-acting antiviral agents, such as simeprevir or daclatasvir, may require dosage adjustments to avoid adverse effects.
• Drugs that affect liver enzymes, like carbamazepine or phenytoin, may alter Sofosbuvir's metabolism and require careful monitoring.

Following are the food interactions for Sofosbuvir 400mg Tablet:

• Sofosbuvir can be taken with or without food, but maintaining a consistent routine is advisable.
• Grapefruit and grapefruit juice should be avoided as they may decrease the elimination of Sofosbuvir, potentially increasing the risk of side effects.
• Alcohol intake is generally not recommended during treatment with Sofosbuvir, as it may increase the risk of liver-related issues and reduce the medication's effectiveness.
• High-fat meals may slightly reduce the absorption of Sofosbuvir, but this effect is not considered clinically significant.
• No specific food restrictions are required, but a well-balanced diet is encouraged to support overall health during treatment.
• Patients should maintain adequate hydration and ensure a consistent fluid intake throughout the treatment period.
• Avoid excessive caffeine consumption as it may interact with Sofosbuvir and increase the risk of side effects like insomnia or nervousness.
• Always consult your healthcare provider for personalized advice regarding dietary considerations during Sofosbuvir treatment.

Sofosbuvir 400mg Tablets should be stored in a secure and dry location, preferably in their original packaging, at room temperature, away from excessive heat, direct sunlight, and moisture. It is crucial to keep the tablets out of children's reach to prevent accidental consumption. Ensure the medication remains tightly sealed to maintain its integrity and effectiveness. Regularly check the expiration date, and if the tablets are expired or no longer needed, do not dispose of them in the trash or down the drain. Instead, consult your local pharmacy or healthcare provider for guidance on safe and environmentally friendly disposal practices to prevent any potential harm to the environment.

Following are the quick tips for Sofosbuvir 400mg Tablet:

• Take the tablet as directed by your doctor, typically once daily with or without food.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Maintain a consistent daily routine to ensure you take the medication at the same time each day.
• Inform your doctor about all medications you are taking to avoid potential drug interactions.
• Regularly monitor your liver function and blood cell counts as advised by your healthcare provider.
• Store the tablets in their original packaging at room temperature, away from moisture and heat.
• Do not share this medication with others; it is prescribed specifically for your medical condition.