Sofinox 10g Cream

Sodium Fusidate Cream, containing the active ingredient sodium fusidate, exerts its antibacterial effect primarily against Gram-positive bacteria. Its mechanism of action involves inhibiting bacterial protein synthesis. Specifically, sodium fusidate binds to the 50S subunit of the bacterial ribosome, thereby preventing the translocation step in protein synthesis. This binding interferes with the proper alignment of aminoacyl-tRNA, hindering the formation of peptide bonds and ultimately leading to the cessation of bacterial protein synthesis. By disrupting this vital process, Sodium Fusidate Cream effectively halts bacterial growth and proliferation, making it a valuable agent in the treatment of skin infections caused by susceptible Gram-positive organisms.

Antibacterial/Antifungal (Fusidic Acid Derivative)

Cream

The following are the uses of Sodium Fusidate Cream:

• Used for treating bacterial skin infections, especially those caused by staphylococcal bacteria.
• Used for reducing skin inflammation and swelling associated with infections.
• Used for preventing the spread of infection to surrounding skin areas.
• Used for managing skin conditions like impetigo, folliculitis, and infected eczema.
• Used for promoting healing and preventing scarring in infected wounds.
• Used for controlling recurrent skin infections in susceptible individuals.
• Used for local application to ensure targeted treatment.
• Used for its effectiveness against bacteria resistant to other antibiotics.

In the case of an overdose of Sodium Fusidate Cream, it is important to recognize the potential symptoms. Overuse may lead to skin irritation, redness, or a burning sensation at the application site. In the event of ingestion, nausea, vomiting, or gastrointestinal discomfort could occur. It is advisable to contact a healthcare professional or seek medical advice if an overdose is suspected, as they can provide specific guidance based on individual circumstances.

In the case of a missed dose of Sodium Fusidate Cream, it is important to apply the cream as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose. Gently clean and dry the affected area before applying the cream. If you miss multiple doses, consult your healthcare professional for guidance on how to adjust your dosing schedule and ensure the treatment remains effective.

To apply Sodium Fusidate Cream, clean and dry the affected skin area, then apply a thin layer of the cream directly to the skin, gently rubbing it in, usually two to four times a day or as directed by your healthcare professional.

Here are the conditions and situations when Sodium Fusidate Cream should not be used:

• Avoid using Sodium Fusidate Cream if you have a known allergy or sensitivity to fusidic acid or any of the cream's components.
• Do not apply to areas where there is broken skin, severe inflammation, or open wounds.
• Contraindicated in individuals with a history of severe skin reactions or skin conditions that could be exacerbated by the cream's ingredients.
• Should not be used for long-term treatment without medical supervision, as prolonged use may lead to bacterial resistance.
• Avoid using on large areas of the body or under occlusive dressings without medical advice.
• Not recommended for individuals with a history of severe kidney disease, as the cream's components may require adjustment in such cases.
• Do not use if the cream has expired or shows signs of deterioration.

The side effects of Sodium Fusidate Cream may include:

• Skin irritation or redness at the application site
• Itching or burning sensation
• Dry skin or peeling
• Allergic reactions (skin rash, hives, itching)
• Swelling or inflammation of the skin
• Contact dermatitis
• Increased sensitivity to sunlight

Following are the precautions and warnings:

• Sodium Fusidate Cream should not be used in individuals with a known allergy or hypersensitivity to sodium fusidate or any other ingredients in the cream.
• Avoid applying the cream to broken or severely damaged skin, as it may increase the risk of adverse reactions.
• Wash your hands thoroughly before and after applying the cream to prevent the spread of infection.
• Keep the treated area clean and avoid covering it with airtight dressings or bandages unless directed by a healthcare professional.
• If using other topical medications, apply them at different times to avoid potential interactions.
• Discontinue use and consult a doctor if irritation, redness, or swelling occurs at the application site.
• This cream is for external use only and should not be ingested. Keep it out of reach of children.
• Patients with liver or kidney problems should use this medication with caution and under medical supervision.

Following are the drug interactions for Sodium Fusidate Cream:

• May interact with other topical antibiotics, increasing the risk of skin irritation and reducing the effectiveness of both medications.
• Fusidic acid may decrease the efficacy of oral contraceptives, so alternative contraception methods should be considered during treatment.
• Concomitant use with corticosteroids can lead to increased skin atrophy and delayed wound healing.
• Sodium Fusidate Cream should not be used with other topical medications without medical advice, as it may reduce the efficacy of either product.
• Interaction with systemic medications is unlikely due to minimal systemic absorption, but concurrent use with oral fusidic acid may increase the risk of resistance.
• Caution is advised when using with other topical products containing alcohols, astringents, or peeling agents, as it may cause excessive dryness or irritation.
• The effectiveness of live bacterial vaccines may be diminished when administered during treatment with Sodium Fusidate Cream.

Following are the food interactions to consider when using Sodium Fusidate Cream:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the medication's metabolism, potentially leading to increased drug levels in the body.
• Alcohol consumption should be limited as it may increase the skin's sensitivity and exacerbate side effects like skin irritation or itching.
• Fatty foods may affect the absorption of the medication, so it is advisable to apply the cream at least 1 hour before or after eating high-fat meals.
• Spicy foods might cause skin flushing or irritation, especially if applied near sensitive areas like the face or neck.
• Dairy products, particularly those rich in calcium, could potentially interact with the medication's absorption, so it's best to maintain a gap between eating dairy and applying the cream.
• Avoid applying the cream immediately after consuming hot foods, as elevated skin temperature may enhance the absorption of the medication, potentially increasing the risk of side effects.
• Certain protein-rich foods may influence the effectiveness of the cream, so consider applying it at a different time than consuming high-protein meals.
• Always consult your healthcare provider for specific dietary guidelines while using Sodium Fusidate Cream to ensure optimal treatment outcomes.

Sodium Fusidate Cream should be stored in a cool, dry area, preferably in its original packaging, ensuring the container is tightly sealed to maintain its integrity. Keep it away from direct sunlight, heat sources like radiators or stoves, and moisture-prone areas like bathrooms, as temperature and humidity fluctuations can impact its effectiveness. Always check the cream's expiration date, and never use it past this date. For disposal, do not flush or pour it down the drain; instead, consult a pharmacist or healthcare professional for safe disposal methods. Keep the cream out of children's reach to prevent accidental contact or ingestion. Proper storage and disposal practices ensure the medication's efficacy and safety.

Following are the quick tips for Sodium Fusidate Cream:

• Apply a thin layer of the cream to the affected area as directed by your doctor or pharmacist.
• Wash and dry your hands before applying the cream to ensure hygiene.
• Gently cleanse the affected skin before application, avoiding harsh scrubbing.
• Use a clean fingertip or cotton swab to apply the cream, avoiding contact with eyes and mucous membranes.
• Do not cover the treated area with airtight dressings or bandages unless instructed by your doctor.
• Avoid applying the cream to broken or severely damaged skin.
• Store the cream at room temperature, away from direct sunlight or extreme temperatures.