Solcoseryl (42.5mg/ml) 5ml, 3 Ampoule Injections

The mechanism of action of Polidocanol 5mg injection primarily involves its ability to cause localized irritation and damage to the endothelial cells of blood vessels. When injected into the target vein, Polidocanol disrupts the cell membranes of endothelial cells, leading to denaturation of proteins and subsequent inflammation. This inflammatory response triggers a localized injury, resulting in the formation of a thrombus or blood clot within the treated vein. The thrombus then leads to occlusion and fibrosis of the vein, ultimately causing its closure and reabsorption by the body. The precise mechanism by which Polidocanol induces endothelial cell damage is believed to be through detergent-like properties, causing membrane destabilization and subsequent cell lysis.

Sclerosing agent

injection

The following are the uses of Polidocanol 5mg injection:

• Used for the treatment of varicose veins and spider veins, providing relief from symptoms like pain and swelling.
• Used for sclerotherapy, a procedure to close off damaged or abnormal veins.
• Used for improving blood flow by redirecting it to healthier veins.
• Used for cosmetic purposes to reduce the appearance of unsightly veins.
• Used for managing chronic venous insufficiency and its associated symptoms.
• Used for minimizing the risk of venous ulcers and other complications.
• Used for vein treatment with a good safety profile and precise application.

In the case of an overdose of Polidocanol 5mg injection, the primary concern is the potential for severe allergic reactions and anaphylaxis. Symptoms may include difficulty breathing, rapid or weak pulse, dizziness, and loss of consciousness. If an overdose is suspected, immediate medical intervention is necessary. Treatment focuses on managing the symptoms and may involve oxygen therapy, intravenous fluids, and close monitoring of vital signs to prevent further complications.

In the case of a missed dose of Polidocanol 5mg injection, it is important to consult your healthcare provider for guidance. They will advise you on whether to administer the missed dose as soon as possible or skip it entirely and continue with the next scheduled dose. Do not double the dose to make up for a missed one unless specifically instructed by your doctor. Remember, maintaining a consistent medication schedule is crucial for the effectiveness of the treatment.

To administer the Polidocanol 5mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the entire contents of the vial subcutaneously, ensuring proper needle disposal afterward.

Following are the conditions when Polidocanol 5mg injection should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Polidocanol or any local anesthetics.
• Not recommended for patients with severe renal (kidney) impairment or end-stage renal disease.
• Should not be used in individuals with a history of severe cardiovascular disease, including uncontrolled hypertension (high blood pressure).
• Contraindicated in patients with severe liver disease or impaired liver function.
• Not suitable for individuals with known blood coagulation disorders or those taking anticoagulant medications.
• Should be avoided in patients with a history of severe allergic reactions or anaphylaxis to any medication.
• Must not be injected into inflamed, infected, or broken skin areas.
• Not recommended for patients with a history of peripheral vascular disease or severe circulatory disorders.
• Contraindicated during pregnancy and breastfeeding, as the risks are unknown.

The side effects of Polidocanol 5mg injection may include:

• Pain, swelling, or irritation at the injection site.
• Itching or rash.
• Localized allergic reactions.
• Numbness or tingling.
• Temporary skin discoloration.
• Hives or urticaria.
• In rare cases, more severe allergic reactions may occur, including difficulty breathing, rapid heartbeat, and dizziness.

Following are the precautions and warnings for Polidocanol 5mg injection:

• Avoid use in patients with known hypersensitivity to polidocanol or any of its components.
• Should not be injected into areas of compromised circulation, such as inflamed, infected, or necrotic tissue.
• Use with caution in patients with a history of cardiovascular diseases, as the injection may cause transient changes in blood pressure or heart rate.
• Should not be used for intravenous injection or injection into large veins.
• The injection must be administered by a healthcare professional experienced in sclerotherapy techniques.
• Avoid accidental injection into arteries, as this may lead to severe complications, including tissue necrosis or embolism.
• May cause local irritation, pain, or swelling at the injection site; consult a healthcare provider if symptoms persist.
• Not recommended during pregnancy or breastfeeding unless clearly needed and prescribed by a healthcare provider.
• Monitor patients for signs of hypersensitivity reactions, including rash, swelling, or difficulty breathing.
• Avoid use in patients with a history of blood clotting disorders or active thromboembolic conditions.
• Patients should avoid excessive physical activity or standing for prolonged periods following treatment.

Following are the drug interactions for Polidocanol 5mg injection:

• Local anesthetics, when used with Polidocanol, may increase the risk of systemic toxicity and adverse effects.
• Combining Polidocanol with other sclerosing agents can lead to enhanced local tissue damage and increased risk of ulceration.
• The injection may interact with anticoagulant medications, increasing the risk of bleeding.
• Use with caution when taking nonsteroidal anti-inflammatory drugs (NSAIDs) as it may increase the likelihood of bleeding and hematoma formation.
• Polidocanol can potentially interact with anti-platelet drugs, further affecting clotting ability.
• It may also interact with herbal supplements that affect blood clotting, such as garlic, ginger, or ginkgo biloba.
• Caution is advised when combining Polidocanol with other medications that cause skin sensitivity or irritation, as this may increase the risk of local skin reactions.

Following are the food interactions to consider with Polidocanol 5mg injection:

• Polidocanol may cause dizziness and drowsiness, so avoid alcohol and any food or drink that can impair your alertness.
• Grapefruit and grapefruit juice should be avoided as they can alter the blood levels of certain medications and potentially impact their effectiveness.
• Avoid caffeine-rich foods and beverages as they may enhance the absorption of Polidocanol, leading to increased side effects.
• Do not consume fatty or greasy meals before or after the injection, as it may affect the absorption and distribution of the medication.
• Avoid high-sodium foods as they can interact with the medication's effects on blood pressure.
• Inform your doctor if you have a history of liver or kidney disease, as certain foods like salty, fatty, or highly processed items may need to be adjusted in your diet.
• Always follow the dietary instructions provided by your healthcare professional to ensure the medication's effectiveness and minimize potential food-related interactions.

Polidocanol 5mg injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. Maintain a temperature range between 15°C and 25°C (59°F and 77°F) to ensure the medication's stability. Store the injections in their original packaging, ensuring the seal is intact, to prevent contamination. It is crucial not to freeze the injections as it may affect their potency. When disposing of unused or expired injections, do not discard them in regular household waste or pour them down the drain. Contact your local waste management authorities or healthcare provider for instructions on proper disposal methods to minimize environmental impact. Keep the medication safely locked away from children and pets to prevent accidental exposure.

Following are the quick tips for Polidocanol 5mg injection:

• Ensure a sterile environment and clean the injection site with an antiseptic before administering the injection.
• Inject the medication slowly as directed by your healthcare professional.
• Dispose of used needles and syringes safely in a designated sharps container.
• Avoid injecting into areas with broken skin, bruises, or inflammation.
• Rotate injection sites to prevent skin irritation and tissue damage.
• Do not reuse or share needles to prevent infection and disease transmission.
• Store the injection as directed on the packaging, away from direct sunlight and moisture.